Advanced Glycation Endproducts and Bone Material Properties in Type 1 Diabetic Mice

Fractures, particularly at the lower extremities and hip, are a complication of diabetes. In both type 1 (T1D) and type 2 diabetes (T2D), fracture risk is disproportionately worse than that predicted from the measurement of bone mineral density. Although an explanation for this discrepancy is the pr...

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Veröffentlicht in:	PloS one 2016-05, Vol.11 (5), p.e0154700-e0154700
Hauptverfasser:	Rubin, Mishaela R, Paschalis, Eleftherios P, Poundarik, Atharva, Sroga, Gyna E, McMahon, Donald J, Gamsjaeger, Sonja, Klaushofer, Klaus, Vashishth, Deepak
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Advanced glycosylation end products Age Alcohol Analysis Animals Biology and Life Sciences Biomechanical Phenomena Biomechanics Biomedical engineering Biotechnology Boltzmann, Ludwig Eduard (1844-1906) Bone and Bones - physiopathology Bone densitometry Bone Density Bone diseases Bone mineral density Chronology Collagen Crack propagation Diabetes Diabetes mellitus Diabetes mellitus (insulin dependent) Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Experimental - complications Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - physiopathology Diabetes Mellitus, Type 1 - complications Diabetes Mellitus, Type 1 - metabolism Diabetes Mellitus, Type 1 - physiopathology Diabetic retinopathy Extremities Female Fourier transforms Fracture mechanics Fracture toughness Fractures Fractures, Bone - complications Glycation End Products, Advanced - metabolism Glycosylation Health risks Hip Hospitals Indentation Interdisciplinary aspects Laboratory animals Lipids Lysine Mechanical Phenomena Mechanical properties Medicine and Health Sciences Metabolism Mice Microhardness Physical Sciences Proteins Research and Analysis Methods Risk factors Studies Surgeons Transgenic mice Trauma Type 1 diabetes
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