Elastin Fiber Accumulation in Liver Correlates with the Development of Hepatocellular Carcinoma
The fibrosis stage, which is evaluated by the distribution pattern of collagen fibers, is a major predictor for the development of hepatocellular carcinoma (HCC) for patients with hepatitis C. Meanwhile, the role of elastin fibers has not yet been elucidated. The present study was conducted to deter...
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| Veröffentlicht in: | PloS one 2016-04, Vol.11 (4), p.e0154558-e0154558 |
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| creator | Yasui, Yutaka Abe, Tokiya Kurosaki, Masayuki Higuchi, Mayu Komiyama, Yasuyuki Yoshida, Tsubasa Hayashi, Tsuguru Kuwabara, Konomi Takaura, Kenta Nakakuki, Natsuko Takada, Hitomi Tamaki, Nobuharu Suzuki, Shoko Nakanishi, Hiroyuki Tsuchiya, Kaoru Itakura, Jun Takahashi, Yuka Hashiguchi, Akinori Sakamoto, Michiie Izumi, Namiki |
| description | The fibrosis stage, which is evaluated by the distribution pattern of collagen fibers, is a major predictor for the development of hepatocellular carcinoma (HCC) for patients with hepatitis C. Meanwhile, the role of elastin fibers has not yet been elucidated. The present study was conducted to determine the significance of quantifying both collagen and elastin fibers.
We enrolled 189 consecutive patients with hepatitis C and advanced fibrosis. Using Elastica van Gieson-stained whole-slide images of pretreatment liver biopsies, collagen and elastin fibers were evaluated pixel by pixel (0.46 μm/pixel) using an automated computational method. Consequently, fiber amount and cumulative incidences of HCC within 3 years were analyzed.
There was a significant correlation between collagen and elastin fibers, whereas variation in elastin fiber was greater than in collagen fiber. Both collagen fiber (p = 0.008) and elastin fiber (p < 0.001) were significantly correlated with F stage. In total, 30 patients developed HCC during follow-up. Patients who have higher elastin fiber (p = 0.002) in addition to higher collagen fiber (p = 0.05) showed significantly higher incidences of HCC. With regard to elastin fiber, this difference remained significant in F3 patients. Furthermore, for patients with a higher collagen fiber amount, higher elastin was a significant predictor for HCC development (p = 0.02).
Computational analysis is a novel technique for quantification of fibers with the added value of conventional staging. Elastin fiber is a predictor for the development of HCC independently of collagen fiber and F stage. |
| doi_str_mv | 10.1371/journal.pone.0154558 |
| format | Article |
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We enrolled 189 consecutive patients with hepatitis C and advanced fibrosis. Using Elastica van Gieson-stained whole-slide images of pretreatment liver biopsies, collagen and elastin fibers were evaluated pixel by pixel (0.46 μm/pixel) using an automated computational method. Consequently, fiber amount and cumulative incidences of HCC within 3 years were analyzed.
There was a significant correlation between collagen and elastin fibers, whereas variation in elastin fiber was greater than in collagen fiber. Both collagen fiber (p = 0.008) and elastin fiber (p < 0.001) were significantly correlated with F stage. In total, 30 patients developed HCC during follow-up. Patients who have higher elastin fiber (p = 0.002) in addition to higher collagen fiber (p = 0.05) showed significantly higher incidences of HCC. With regard to elastin fiber, this difference remained significant in F3 patients. Furthermore, for patients with a higher collagen fiber amount, higher elastin was a significant predictor for HCC development (p = 0.02).
Computational analysis is a novel technique for quantification of fibers with the added value of conventional staging. Elastin fiber is a predictor for the development of HCC independently of collagen fiber and F stage.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0154558</identifier><identifier>PMID: 27128435</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Aged ; Automation ; Biology and Life Sciences ; Carcinoma, Hepatocellular - epidemiology ; Carcinoma, Hepatocellular - etiology ; Carcinoma, Hepatocellular - metabolism ; Care and treatment ; Collagen ; Collagen - metabolism ; Complications and side effects ; Computation ; Computer applications ; Elastin ; Elastin - metabolism ; Female ; Fibers ; Fibrosis ; Gastroenterology ; Growth factors ; Health aspects ; Hepatitis ; Hepatitis C ; Hepatitis C, Chronic - complications ; Hepatitis C, Chronic - metabolism ; Hepatitis C, Chronic - pathology ; Hepatocellular carcinoma ; Hepatology ; Humans ; Incidence ; Infections ; Influence ; Interferon ; Liver ; Liver - metabolism ; Liver - pathology ; Liver cancer ; Liver cirrhosis ; Liver Cirrhosis - complications ; Liver Cirrhosis - metabolism ; Liver Cirrhosis - pathology ; Liver diseases ; Liver Neoplasms - epidemiology ; Liver Neoplasms - etiology ; Liver Neoplasms - metabolism ; Male ; Medicine and Health Sciences ; Middle Aged ; Pathology ; Patients ; Pixels ; Risk Factors ; Viral infections</subject><ispartof>PloS one, 2016-04, Vol.11 (4), p.e0154558-e0154558</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Yasui et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2016 Yasui et al 2016 Yasui et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-16b885b7a4c4e56a2c4be207af89590d9dffad49996ce95b0d210cfa82675a2b3</citedby><cites>FETCH-LOGICAL-c692t-16b885b7a4c4e56a2c4be207af89590d9dffad49996ce95b0d210cfa82675a2b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851385/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851385/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,2096,2915,23847,27905,27906,53772,53774,79349,79350</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27128435$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Huang, Yi-Hsiang</contributor><creatorcontrib>Yasui, Yutaka</creatorcontrib><creatorcontrib>Abe, Tokiya</creatorcontrib><creatorcontrib>Kurosaki, Masayuki</creatorcontrib><creatorcontrib>Higuchi, Mayu</creatorcontrib><creatorcontrib>Komiyama, Yasuyuki</creatorcontrib><creatorcontrib>Yoshida, Tsubasa</creatorcontrib><creatorcontrib>Hayashi, Tsuguru</creatorcontrib><creatorcontrib>Kuwabara, Konomi</creatorcontrib><creatorcontrib>Takaura, Kenta</creatorcontrib><creatorcontrib>Nakakuki, Natsuko</creatorcontrib><creatorcontrib>Takada, Hitomi</creatorcontrib><creatorcontrib>Tamaki, Nobuharu</creatorcontrib><creatorcontrib>Suzuki, Shoko</creatorcontrib><creatorcontrib>Nakanishi, Hiroyuki</creatorcontrib><creatorcontrib>Tsuchiya, Kaoru</creatorcontrib><creatorcontrib>Itakura, Jun</creatorcontrib><creatorcontrib>Takahashi, Yuka</creatorcontrib><creatorcontrib>Hashiguchi, Akinori</creatorcontrib><creatorcontrib>Sakamoto, Michiie</creatorcontrib><creatorcontrib>Izumi, Namiki</creatorcontrib><title>Elastin Fiber Accumulation in Liver Correlates with the Development of Hepatocellular Carcinoma</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The fibrosis stage, which is evaluated by the distribution pattern of collagen fibers, is a major predictor for the development of hepatocellular carcinoma (HCC) for patients with hepatitis C. Meanwhile, the role of elastin fibers has not yet been elucidated. The present study was conducted to determine the significance of quantifying both collagen and elastin fibers.
We enrolled 189 consecutive patients with hepatitis C and advanced fibrosis. Using Elastica van Gieson-stained whole-slide images of pretreatment liver biopsies, collagen and elastin fibers were evaluated pixel by pixel (0.46 μm/pixel) using an automated computational method. Consequently, fiber amount and cumulative incidences of HCC within 3 years were analyzed.
There was a significant correlation between collagen and elastin fibers, whereas variation in elastin fiber was greater than in collagen fiber. Both collagen fiber (p = 0.008) and elastin fiber (p < 0.001) were significantly correlated with F stage. In total, 30 patients developed HCC during follow-up. Patients who have higher elastin fiber (p = 0.002) in addition to higher collagen fiber (p = 0.05) showed significantly higher incidences of HCC. With regard to elastin fiber, this difference remained significant in F3 patients. Furthermore, for patients with a higher collagen fiber amount, higher elastin was a significant predictor for HCC development (p = 0.02).
Computational analysis is a novel technique for quantification of fibers with the added value of conventional staging. Elastin fiber is a predictor for the development of HCC independently of collagen fiber and F stage.</description><subject>Aged</subject><subject>Automation</subject><subject>Biology and Life Sciences</subject><subject>Carcinoma, Hepatocellular - epidemiology</subject><subject>Carcinoma, Hepatocellular - etiology</subject><subject>Carcinoma, Hepatocellular - metabolism</subject><subject>Care and treatment</subject><subject>Collagen</subject><subject>Collagen - metabolism</subject><subject>Complications and side effects</subject><subject>Computation</subject><subject>Computer applications</subject><subject>Elastin</subject><subject>Elastin - metabolism</subject><subject>Female</subject><subject>Fibers</subject><subject>Fibrosis</subject><subject>Gastroenterology</subject><subject>Growth factors</subject><subject>Health aspects</subject><subject>Hepatitis</subject><subject>Hepatitis C</subject><subject>Hepatitis C, Chronic - complications</subject><subject>Hepatitis C, Chronic - metabolism</subject><subject>Hepatitis C, Chronic - pathology</subject><subject>Hepatocellular carcinoma</subject><subject>Hepatology</subject><subject>Humans</subject><subject>Incidence</subject><subject>Infections</subject><subject>Influence</subject><subject>Interferon</subject><subject>Liver</subject><subject>Liver - metabolism</subject><subject>Liver - pathology</subject><subject>Liver cancer</subject><subject>Liver cirrhosis</subject><subject>Liver Cirrhosis - complications</subject><subject>Liver Cirrhosis - metabolism</subject><subject>Liver Cirrhosis - pathology</subject><subject>Liver diseases</subject><subject>Liver Neoplasms - epidemiology</subject><subject>Liver Neoplasms - etiology</subject><subject>Liver Neoplasms - metabolism</subject><subject>Male</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Pathology</subject><subject>Patients</subject><subject>Pixels</subject><subject>Risk Factors</subject><subject>Viral 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titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yasui, Yutaka</au><au>Abe, Tokiya</au><au>Kurosaki, Masayuki</au><au>Higuchi, Mayu</au><au>Komiyama, Yasuyuki</au><au>Yoshida, Tsubasa</au><au>Hayashi, Tsuguru</au><au>Kuwabara, Konomi</au><au>Takaura, Kenta</au><au>Nakakuki, Natsuko</au><au>Takada, Hitomi</au><au>Tamaki, Nobuharu</au><au>Suzuki, Shoko</au><au>Nakanishi, Hiroyuki</au><au>Tsuchiya, Kaoru</au><au>Itakura, Jun</au><au>Takahashi, Yuka</au><au>Hashiguchi, Akinori</au><au>Sakamoto, Michiie</au><au>Izumi, Namiki</au><au>Huang, Yi-Hsiang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Elastin Fiber Accumulation in Liver Correlates with the Development of Hepatocellular Carcinoma</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2016-04-29</date><risdate>2016</risdate><volume>11</volume><issue>4</issue><spage>e0154558</spage><epage>e0154558</epage><pages>e0154558-e0154558</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The fibrosis stage, which is evaluated by the distribution pattern of collagen fibers, is a major predictor for the development of hepatocellular carcinoma (HCC) for patients with hepatitis C. Meanwhile, the role of elastin fibers has not yet been elucidated. The present study was conducted to determine the significance of quantifying both collagen and elastin fibers.
We enrolled 189 consecutive patients with hepatitis C and advanced fibrosis. Using Elastica van Gieson-stained whole-slide images of pretreatment liver biopsies, collagen and elastin fibers were evaluated pixel by pixel (0.46 μm/pixel) using an automated computational method. Consequently, fiber amount and cumulative incidences of HCC within 3 years were analyzed.
There was a significant correlation between collagen and elastin fibers, whereas variation in elastin fiber was greater than in collagen fiber. Both collagen fiber (p = 0.008) and elastin fiber (p < 0.001) were significantly correlated with F stage. In total, 30 patients developed HCC during follow-up. Patients who have higher elastin fiber (p = 0.002) in addition to higher collagen fiber (p = 0.05) showed significantly higher incidences of HCC. With regard to elastin fiber, this difference remained significant in F3 patients. Furthermore, for patients with a higher collagen fiber amount, higher elastin was a significant predictor for HCC development (p = 0.02).
Computational analysis is a novel technique for quantification of fibers with the added value of conventional staging. Elastin fiber is a predictor for the development of HCC independently of collagen fiber and F stage.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>27128435</pmid><doi>10.1371/journal.pone.0154558</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2016-04, Vol.11 (4), p.e0154558-e0154558 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1785489550 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Aged Automation Biology and Life Sciences Carcinoma, Hepatocellular - epidemiology Carcinoma, Hepatocellular - etiology Carcinoma, Hepatocellular - metabolism Care and treatment Collagen Collagen - metabolism Complications and side effects Computation Computer applications Elastin Elastin - metabolism Female Fibers Fibrosis Gastroenterology Growth factors Health aspects Hepatitis Hepatitis C Hepatitis C, Chronic - complications Hepatitis C, Chronic - metabolism Hepatitis C, Chronic - pathology Hepatocellular carcinoma Hepatology Humans Incidence Infections Influence Interferon Liver Liver - metabolism Liver - pathology Liver cancer Liver cirrhosis Liver Cirrhosis - complications Liver Cirrhosis - metabolism Liver Cirrhosis - pathology Liver diseases Liver Neoplasms - epidemiology Liver Neoplasms - etiology Liver Neoplasms - metabolism Male Medicine and Health Sciences Middle Aged Pathology Patients Pixels Risk Factors Viral infections |
| title | Elastin Fiber Accumulation in Liver Correlates with the Development of Hepatocellular Carcinoma |
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