HCV Specific IL-21 Producing T Cells but Not IL-17A Producing T Cells Are Associated with HCV Viral Control in HIV/HCV Coinfection

Decreased hepatitis C virus (HCV) clearance, faster cirrhosis progression and higher HCV RNA levels are associated with Human Immunodeficiency virus (HIV) coinfection. The CD4+ T helper cytokines interleukin (IL)-21 and IL-17A are associated with virus control and inflammation, respectively, both im...

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Veröffentlicht in:	PloS one 2016-04, Vol.11 (4), p.e0154433-e0154433
Hauptverfasser:	MacParland, Sonya A, Fadel, Saleh M, Mihajlovic, Vesna, Fawaz, Ali, Kim, Connie, Rahman, A K M Nur-Ur, Liu, Jun, Kaul, Rupert, Kovacs, Colin, Grebely, Jason, Dore, Gregory J, Wong, David K, Ostrowski, Mario A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antigens Antiretroviral drugs Bacterial infections Biology and Life Sciences CD4 antigen CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - pathology CD4-Positive T-Lymphocytes - virology CD8 antigen CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - pathology CD8-Positive T-Lymphocytes - virology Chronic infection Cirrhosis Coinfection Complications and side effects Concurrent infection Control methods Cross-Sectional Studies Cytokines Disease control Female Fibrosis Gene Expression Hepacivirus - growth & development Hepacivirus - immunology Hepatitis Hepatitis C Hepatitis C virus Hepatitis C, Chronic - immunology Hepatitis C, Chronic - pathology Hepatitis C, Chronic - virology Highly active antiretroviral therapy HIV HIV infections HIV Infections - immunology HIV Infections - pathology HIV Infections - virology HIV-1 - growth & development HIV-1 - immunology Hospitals Human immunodeficiency virus Humans Immunity, Cellular Immunology Infections Infectious diseases Influence Interferon Interleukin 21 Interleukin-17 - genetics Interleukin-17 - immunology Interleukin-17 - metabolism Interleukins Interleukins - genetics Interleukins - immunology Interleukins - metabolism Liver cirrhosis Liver diseases Longitudinal Studies Lymphocytes Lymphocytes T Male Measurement methods Medicine Medicine and Health Sciences Microorganisms Middle Aged Primary Cell Culture Ribonucleic acid Risk factors RNA Translocation Viral Load - immunology Viruses
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