Pelvic Organ Support in Animals with Partial Loss of Fibulin-5 in the Vaginal Wall

Compromise of elastic fiber integrity in connective tissues of the pelvic floor is most likely acquired through aging, childbirth-associated injury, and genetic susceptibility. Mouse models of pelvic organ prolapse demonstrate systemic deficiencies in proteins that affect elastogenesis. Prolapse, ho...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2016-04, Vol.11 (4), p.e0152793-e0152793
Hauptverfasser:	Chin, Kathleen, Wieslander, Cecilia, Shi, Haolin, Balgobin, Sunil, Montoya, T Ignacio, Yanagisawa, Hiromi, Word, R Ann
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Actins - metabolism Adults Age Aging Animal models Animal tissues Animals Biology and Life Sciences Body length Care and treatment Childbirth & labor Clonal deletion Connective tissues Cre recombinase Doxycycline Elastase Elastic Tissue - metabolism Emphysema Extracellular Matrix Proteins - metabolism Fecal incontinence Female Females Gelatinase B Gynecology Health aspects Kinases Male Matrix Metalloproteinase 9 - metabolism Medicine Medicine and Health Sciences Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic - metabolism Models, Animal Muscle, Smooth - metabolism Muscles Obstetrics Organs (Anatomy) Pancreatic Elastase - metabolism Parturition Parturition - metabolism Pathogenesis Pelvic floor Pelvic Floor - physiology Pelvic Organ Prolapse - metabolism People and Places Physical Sciences Postpartum Postpartum Period - metabolism Pregnancy Proteins Recombinant Proteins - metabolism Recombinase Recovery Regulatory sequences Research and Analysis Methods Rodents Smooth muscle Stromal cells Transgenic animals Vagina Vagina - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!