Nitrated Fatty Acids Reverse Cigarette Smoke-Induced Alveolar Macrophage Activation and Inhibit Protease Activity via Electrophilic S-Alkylation

Nitrated fatty acids (NFAs), endogenous products of nonenzymatic reactions of NO-derived reactive nitrogen species with unsaturated fatty acids, exhibit substantial anti-inflammatory activities. They are both reversible electrophiles and peroxisome proliferator-activated receptor γ (PPARγ) agonists,...

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Veröffentlicht in:	PloS one 2016-04, Vol.11 (4), p.e0153336
Hauptverfasser:	Reddy, Aravind T, Lakshmi, Sowmya P, Muchumarri, Ramamohan R, Reddy, Raju C
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylation Alkylation - drug effects Alveoli Analysis Animals Anti-Inflammatory Agents - pharmacology Binding sites Biology and Life Sciences Biomarkers Biomarkers - metabolism Cathepsin S Cathepsins - metabolism Causes of Cell activation Chemokines Chronic obstructive lung disease Chronic obstructive pulmonary disease Cigarette smoke Critical care Cytokines Destruction Down-Regulation - drug effects Emphysema Fatty acids Fatty Acids - physiology Immunology Inflammation Inflammation - metabolism Inhibition Ligands Lung diseases Macrophage Activation - drug effects Macrophages Macrophages, Alveolar - drug effects Macrophages, Alveolar - metabolism Male Medicine Medicine and Health Sciences Mice Mice, Inbred C57BL Neutrophils NF-kappa B - metabolism NF-κB protein Nicotiana - adverse effects Nitrates - physiology Obstructive lung disease Oleic acid Oleic Acids - pharmacology Pathogenesis Pathological physiology Physical Sciences Physiological aspects PPAR gamma - metabolism Protease Proteinase Proteins Pulmonary Disease, Chronic Obstructive - drug therapy Pulmonary Disease, Chronic Obstructive - metabolism Pulmonary Emphysema - drug therapy Pulmonary Emphysema - metabolism Reactive nitrogen species Research and Analysis Methods Risk factors Smoke Smoke - adverse effects Smoking - adverse effects Transcription factors Up-Regulation - drug effects Veterans
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