The Pharmacogenetic Footprint of ACE Inhibition: A Population-Based Metabolomics Study

Angiotensin-I-converting enzyme (ACE) inhibitors are an important class of antihypertensives whose action on the human organism is still not fully understood. Although it is known that ACE especially cleaves COOH-terminal dipeptides from active polypeptides, the whole range of substrates and product...

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Veröffentlicht in:	PloS one 2016-04, Vol.11 (4), p.e0153163
Hauptverfasser:	Altmaier, Elisabeth, Menni, Cristina, Heier, Margit, Meisinger, Christa, Thorand, Barbara, Quell, Jan, Kobl, Michael, Römisch-Margl, Werner, Valdes, Ana M, Mangino, Massimo, Waldenberger, Melanie, Strauch, Konstantin, Illig, Thomas, Adamski, Jerzy, Spector, Tim, Gieger, Christian, Suhre, Karsten, Kastenmüller, Gabi
Format:	Artikel
Sprache:	eng
Schlagworte:	ACE protein Adult Aged Agent Orange Angiotensin-converting enzyme inhibitors Angiotensin-Converting Enzyme Inhibitors - therapeutic use Antihypertensive agents Antihypertensive Agents - therapeutic use Antihypertensives Bioinformatics Biology Biology and Life Sciences Blood Blood levels Blood pressure Blood Pressure - drug effects Blood Pressure - genetics Cardiovascular diseases Chemical industry Diabetes Dipeptides - metabolism Environmental health Enzymes Epidemiology Female Genetic diversity Genetic variance Genetic Variation - drug effects Genetic Variation - genetics Genetics Genomes Genotype Genotypes Health aspects Heterozygotes Homozygotes Humans Hypertension Hypertension - drug therapy Hypertension - genetics Hypertension - metabolism Inhibitors Loci Male Mass spectrometry Medical research Medicine and health sciences Metabolism Metabolites Metabolome - drug effects Metabolome - genetics Metabolomics Metabolomics - methods Middle Aged Narcotics Oligopeptides Oligopeptides - metabolism Peptides Peptidyl-Dipeptidase A - genetics Peptidyl-Dipeptidase A - metabolism Pharmacogenetics - methods Pharmacology Physical Sciences Physiology Polypeptides Population studies Population-based studies Research and Analysis Methods Risk factors Scientific imaging Studies Substrates
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