Cervical Microbiome and Cytokine Profile at Various Stages of Cervical Cancer: A Pilot Study

Cervical cancer (CC) is caused by high-risk human papillomavirus persistence due to the immunosuppressive tumor microenvironment mediated by cytokines. Vaginal microbiota determines the presence of certain cytokines locally. We assessed the association between cervical microbiota diversity and the h...

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Veröffentlicht in:	PloS one 2016-04, Vol.11 (4), p.e0153274-e0153274
Hauptverfasser:	Audirac-Chalifour, Astride, Torres-Poveda, Kirvis, Bahena-Román, Margarita, Téllez-Sosa, Juan, Martínez-Barnetche, Jesús, Cortina-Ceballos, Bernardo, López-Estrada, Guillermina, Delgado-Romero, Karina, Burguete-García, Ana I, Cantú, David, García-Carrancá, Alejandro, Madrid-Marina, Vicente
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Analysis Bacteria Biology and Life Sciences Cancer Carcinoma, Squamous Cell - immunology Carcinoma, Squamous Cell - microbiology Carcinoma, Squamous Cell - pathology Cervical cancer Cervix Cross-Sectional Studies Cytokines Cytokines - genetics Cytology Diagnosis Ecology and Environmental Sciences Female Fusobacterium Gene expression Health risks Human papillomavirus Humans Immunosuppression Interferon Interferon-gamma - genetics Interleukin 10 Interleukin 4 Interleukin 6 Interleukin-10 - genetics Interleukin-4 - genetics Interleukin-6 - genetics Lesions Medicine and Health Sciences Microbiomes Microbiota Middle Aged Neoplasm Staging Next-generation sequencing Papillomavirus infections Research and Analysis Methods Risk factors RNA, Messenger - genetics RNA, Neoplasm - genetics rRNA 16S Squamous Intraepithelial Lesions of the Cervix - immunology Squamous Intraepithelial Lesions of the Cervix - microbiology Squamous Intraepithelial Lesions of the Cervix - pathology Transcriptome Transforming Growth Factor beta1 - genetics Transforming growth factor-b1 Tumor Necrosis Factor-alpha - genetics Tumor necrosis factor-α Uterine Cervical Neoplasms - immunology Uterine Cervical Neoplasms - microbiology Uterine Cervical Neoplasms - pathology Vagina γ-Interferon
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