Maternal Dietary Supplementation with Oligofructose-Enriched Inulin in Gestating/Lactating Rats Preserves Maternal Bone and Improves Bone Microarchitecture in Their Offspring
Nutrition during pregnancy and lactation could exert a key role not only on maternal bone, but also could influence the skeletal development of the offspring. This study was performed in rats to assess the relationship between maternal dietary intake of prebiotic oligofructose-enriched inulin and it...
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| description | Nutrition during pregnancy and lactation could exert a key role not only on maternal bone, but also could influence the skeletal development of the offspring. This study was performed in rats to assess the relationship between maternal dietary intake of prebiotic oligofructose-enriched inulin and its role in bone turnover during gestation and lactation, as well as its effect on offspring peak bone mass/architecture during early adulthood. Rat dams were fed either with standard rodent diet (CC group), calcium-fortified diet (Ca group), or prebiotic oligofructose-enriched inulin supplemented diet (Pre group), during the second half of gestation and lactation. Bone mineral density (BMD) and content (BMC), as well as micro-structure of dams and offspring at different stages were analysed. Dams in the Pre group had significantly higher trabecular thickness (Tb.Th), trabecular bone volume fraction (BV/TV) and smaller specific bone surface (BS/BV) of the tibia in comparison with CC dams. The Pre group offspring during early adulthood had an increase of the lumbar vertebra BMD when compared with offspring of CC and Ca groups. The Pre group offspring also showed significant increase versus CC in cancellous and cortical structural parameters of the lumbar vertebra 4 such as Tb.Th, cortical BMD and decreased BS/BV. The results indicate that oligofructose-enriched inulin supplementation can be considered as a plausible nutritional option for protecting against maternal bone loss during gestation and lactation preventing bone fragility and for optimizing peak bone mass and architecture of the offspring in order to increase bone strength. |
| doi_str_mv | 10.1371/journal.pone.0154120 |
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This study was performed in rats to assess the relationship between maternal dietary intake of prebiotic oligofructose-enriched inulin and its role in bone turnover during gestation and lactation, as well as its effect on offspring peak bone mass/architecture during early adulthood. Rat dams were fed either with standard rodent diet (CC group), calcium-fortified diet (Ca group), or prebiotic oligofructose-enriched inulin supplemented diet (Pre group), during the second half of gestation and lactation. Bone mineral density (BMD) and content (BMC), as well as micro-structure of dams and offspring at different stages were analysed. Dams in the Pre group had significantly higher trabecular thickness (Tb.Th), trabecular bone volume fraction (BV/TV) and smaller specific bone surface (BS/BV) of the tibia in comparison with CC dams. The Pre group offspring during early adulthood had an increase of the lumbar vertebra BMD when compared with offspring of CC and Ca groups. The Pre group offspring also showed significant increase versus CC in cancellous and cortical structural parameters of the lumbar vertebra 4 such as Tb.Th, cortical BMD and decreased BS/BV. The results indicate that oligofructose-enriched inulin supplementation can be considered as a plausible nutritional option for protecting against maternal bone loss during gestation and lactation preventing bone fragility and for optimizing peak bone mass and architecture of the offspring in order to increase bone strength.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0154120</identifier><identifier>PMID: 27115490</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject><![CDATA[Animals ; Biology and Life Sciences ; Bone and Bones - anatomy & histology ; Bone and Bones - drug effects ; Bone and Bones - ultrastructure ; Bone density ; Bone Density - drug effects ; Bone Development - drug effects ; Bone loss ; Bone mass ; Bone mineral density ; Bone strength ; Bone turnover ; Calcium ; Cancellous bone ; Child development ; Computer architecture ; Concentration (composition) ; Dams ; Diet ; Dietary intake ; Dietary supplements ; Enrichment ; Female ; Food and nutrition ; Food science ; Fragility ; Fructooligosaccharides ; Gestation ; Inulin ; Inulin - administration & dosage ; Inulin - pharmacology ; Lactation ; Lactation - drug effects ; Medicine and Health Sciences ; Metabolism ; Mineralization ; Nutrition ; Nutrition research ; Offspring ; Oligosaccharides - administration & dosage ; Osteoporosis ; Pharmacy ; Physiological aspects ; Physiology ; Prebiotics ; Prebiotics - administration & dosage ; Prebiotics - analysis ; Pregnancy ; Pregnant women ; Rats ; Rats - anatomy & histology ; Rats - growth & development ; Rats - physiology ; Rats, Sprague-Dawley ; Spine ; Studies ; Tibia ; Vargas, Manuel ; Vertebrae ; Womens health]]></subject><ispartof>PloS one, 2016-04, Vol.11 (4), p.e0154120</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Bueno-Vargas et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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This study was performed in rats to assess the relationship between maternal dietary intake of prebiotic oligofructose-enriched inulin and its role in bone turnover during gestation and lactation, as well as its effect on offspring peak bone mass/architecture during early adulthood. Rat dams were fed either with standard rodent diet (CC group), calcium-fortified diet (Ca group), or prebiotic oligofructose-enriched inulin supplemented diet (Pre group), during the second half of gestation and lactation. Bone mineral density (BMD) and content (BMC), as well as micro-structure of dams and offspring at different stages were analysed. Dams in the Pre group had significantly higher trabecular thickness (Tb.Th), trabecular bone volume fraction (BV/TV) and smaller specific bone surface (BS/BV) of the tibia in comparison with CC dams. The Pre group offspring during early adulthood had an increase of the lumbar vertebra BMD when compared with offspring of CC and Ca groups. The Pre group offspring also showed significant increase versus CC in cancellous and cortical structural parameters of the lumbar vertebra 4 such as Tb.Th, cortical BMD and decreased BS/BV. 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bueno-Vargas, Pilar</au><au>Manzano, Manuel</au><au>Diaz-Castro, Javier</au><au>López-Aliaga, Inmaculada</au><au>Rueda, Ricardo</au><au>López-Pedrosa, Jose María</au><au>Ashton, Nick</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Maternal Dietary Supplementation with Oligofructose-Enriched Inulin in Gestating/Lactating Rats Preserves Maternal Bone and Improves Bone Microarchitecture in Their Offspring</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2016-04-26</date><risdate>2016</risdate><volume>11</volume><issue>4</issue><spage>e0154120</spage><pages>e0154120-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Nutrition during pregnancy and lactation could exert a key role not only on maternal bone, but also could influence the skeletal development of the offspring. This study was performed in rats to assess the relationship between maternal dietary intake of prebiotic oligofructose-enriched inulin and its role in bone turnover during gestation and lactation, as well as its effect on offspring peak bone mass/architecture during early adulthood. Rat dams were fed either with standard rodent diet (CC group), calcium-fortified diet (Ca group), or prebiotic oligofructose-enriched inulin supplemented diet (Pre group), during the second half of gestation and lactation. Bone mineral density (BMD) and content (BMC), as well as micro-structure of dams and offspring at different stages were analysed. Dams in the Pre group had significantly higher trabecular thickness (Tb.Th), trabecular bone volume fraction (BV/TV) and smaller specific bone surface (BS/BV) of the tibia in comparison with CC dams. The Pre group offspring during early adulthood had an increase of the lumbar vertebra BMD when compared with offspring of CC and Ca groups. The Pre group offspring also showed significant increase versus CC in cancellous and cortical structural parameters of the lumbar vertebra 4 such as Tb.Th, cortical BMD and decreased BS/BV. The results indicate that oligofructose-enriched inulin supplementation can be considered as a plausible nutritional option for protecting against maternal bone loss during gestation and lactation preventing bone fragility and for optimizing peak bone mass and architecture of the offspring in order to increase bone strength.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>27115490</pmid><doi>10.1371/journal.pone.0154120</doi><orcidid>https://orcid.org/0000-0002-3733-2047</orcidid><oa>free_for_read</oa></addata></record> |
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| language | eng |
| recordid | cdi_plos_journals_1784460409 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Animals Biology and Life Sciences Bone and Bones - anatomy & histology Bone and Bones - drug effects Bone and Bones - ultrastructure Bone density Bone Density - drug effects Bone Development - drug effects Bone loss Bone mass Bone mineral density Bone strength Bone turnover Calcium Cancellous bone Child development Computer architecture Concentration (composition) Dams Diet Dietary intake Dietary supplements Enrichment Female Food and nutrition Food science Fragility Fructooligosaccharides Gestation Inulin Inulin - administration & dosage Inulin - pharmacology Lactation Lactation - drug effects Medicine and Health Sciences Metabolism Mineralization Nutrition Nutrition research Offspring Oligosaccharides - administration & dosage Osteoporosis Pharmacy Physiological aspects Physiology Prebiotics Prebiotics - administration & dosage Prebiotics - analysis Pregnancy Pregnant women Rats Rats - anatomy & histology Rats - growth & development Rats - physiology Rats, Sprague-Dawley Spine Studies Tibia Vargas, Manuel Vertebrae Womens health |
| title | Maternal Dietary Supplementation with Oligofructose-Enriched Inulin in Gestating/Lactating Rats Preserves Maternal Bone and Improves Bone Microarchitecture in Their Offspring |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T08%3A44%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Maternal%20Dietary%20Supplementation%20with%20Oligofructose-Enriched%20Inulin%20in%20Gestating/Lactating%20Rats%20Preserves%20Maternal%20Bone%20and%20Improves%20Bone%20Microarchitecture%20in%20Their%20Offspring&rft.jtitle=PloS%20one&rft.au=Bueno-Vargas,%20Pilar&rft.date=2016-04-26&rft.volume=11&rft.issue=4&rft.spage=e0154120&rft.pages=e0154120-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0154120&rft_dat=%3Cgale_plos_%3EA453426509%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1784460409&rft_id=info:pmid/27115490&rft_galeid=A453426509&rft_doaj_id=oai_doaj_org_article_699bde30ffcc47408688977733a8235d&rfr_iscdi=true |