Tinnitus Suppression by Intracochlear Electrical Stimulation in Single Sided Deafness - A Prospective Clinical Trial: Follow-Up
Earlier studies show that a Cochlear Implant (CI), capable of providing intracochlear electrical stimulation independent of environmental sounds, appears to suppress tinnitus at least for minutes. The current main objective is to compare the long-term suppressive effects of looped (i.e. repeated) el...
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| description | Earlier studies show that a Cochlear Implant (CI), capable of providing intracochlear electrical stimulation independent of environmental sounds, appears to suppress tinnitus at least for minutes. The current main objective is to compare the long-term suppressive effects of looped (i.e. repeated) electrical stimulation (without environmental sound perception) with the standard stimulation pattern of a CI (with environmental sound perception). This could open new possibilities for the development of a "Tinnitus Implant" (TI), an intracochlear pulse generator for the suppression of tinnitus.
Ten patients with single sided deafness suffering from unilateral tinnitus in the deaf ear are fitted with a CI (MED-EL Corporation, Innsbruck, Austria). Stimulation patterns are optimized for each individual patient, after which they are compared using a randomized crossover design, with a follow-up of six months, followed by a 3 month period using the modality of patient's choice.
Results show that tinnitus can be suppressed with intracochlear electrical stimulation independent of environmental sounds, even long term. No significant difference in tinnitus suppression was found between the standard clinical CI and the TI.
It can be concluded that coding of environmental sounds is no requirement for tinnitus suppression with intracochlear electrical stimulation. It is therefore plausible that tinnitus suppression by CI is not solely caused by an attention shift from the tinnitus to environmental sounds. Both the standard clinical CI and the experimental TI are potential treatment options for tinnitus. These findings offer perspectives for a successful clinical application of the TI, possibly even in patients with significant residual hearing.
TrialRegister.nl NTR3374. |
| doi_str_mv | 10.1371/journal.pone.0153131 |
| format | Article |
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Ten patients with single sided deafness suffering from unilateral tinnitus in the deaf ear are fitted with a CI (MED-EL Corporation, Innsbruck, Austria). Stimulation patterns are optimized for each individual patient, after which they are compared using a randomized crossover design, with a follow-up of six months, followed by a 3 month period using the modality of patient's choice.
Results show that tinnitus can be suppressed with intracochlear electrical stimulation independent of environmental sounds, even long term. No significant difference in tinnitus suppression was found between the standard clinical CI and the TI.
It can be concluded that coding of environmental sounds is no requirement for tinnitus suppression with intracochlear electrical stimulation. It is therefore plausible that tinnitus suppression by CI is not solely caused by an attention shift from the tinnitus to environmental sounds. Both the standard clinical CI and the experimental TI are potential treatment options for tinnitus. These findings offer perspectives for a successful clinical application of the TI, possibly even in patients with significant residual hearing.
TrialRegister.nl NTR3374.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0153131</identifier><identifier>PMID: 27111333</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Acoustics ; Background noise ; Biology and Life Sciences ; Care and treatment ; Clinical trials ; Cochlea ; Cochlea - physiopathology ; Cochlear implants ; Cross-Over Studies ; Deafness ; Deafness - complications ; Deafness - physiopathology ; Ear ; Ears & hearing ; Electric Stimulation ; Electrical stimuli ; Engineering and Technology ; Hearing loss ; Humans ; Materials selection ; Medicine and Health Sciences ; Mental health ; Neurosciences ; Patient outcomes ; Patients ; Perception ; Prospective Studies ; Pulse generators ; Quality of life ; Rehabilitation ; Short term ; Social Sciences ; Stimulation ; Studies ; Surgery ; Systematic review ; Therapeutic applications ; Tinnitus ; Tinnitus - complications ; Tinnitus - prevention & control ; Transplants & implants ; Visual Analog Scale</subject><ispartof>PloS one, 2016-04, Vol.11 (4), p.e0153131-e0153131</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Arts et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2016 Arts et al 2016 Arts et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-9421c0bc84d27aff3617db24c5604fd687f51e56b356bcd88bdf82b08c9fe6453</citedby><cites>FETCH-LOGICAL-c692t-9421c0bc84d27aff3617db24c5604fd687f51e56b356bcd88bdf82b08c9fe6453</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844154/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844154/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27111333$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Arts, Remo A G J</creatorcontrib><creatorcontrib>George, Erwin L J</creatorcontrib><creatorcontrib>Janssen, Miranda</creatorcontrib><creatorcontrib>Griessner, Andreas</creatorcontrib><creatorcontrib>Zierhofer, Clemens</creatorcontrib><creatorcontrib>Stokroos, Robert J</creatorcontrib><title>Tinnitus Suppression by Intracochlear Electrical Stimulation in Single Sided Deafness - A Prospective Clinical Trial: Follow-Up</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Earlier studies show that a Cochlear Implant (CI), capable of providing intracochlear electrical stimulation independent of environmental sounds, appears to suppress tinnitus at least for minutes. The current main objective is to compare the long-term suppressive effects of looped (i.e. repeated) electrical stimulation (without environmental sound perception) with the standard stimulation pattern of a CI (with environmental sound perception). This could open new possibilities for the development of a "Tinnitus Implant" (TI), an intracochlear pulse generator for the suppression of tinnitus.
Ten patients with single sided deafness suffering from unilateral tinnitus in the deaf ear are fitted with a CI (MED-EL Corporation, Innsbruck, Austria). Stimulation patterns are optimized for each individual patient, after which they are compared using a randomized crossover design, with a follow-up of six months, followed by a 3 month period using the modality of patient's choice.
Results show that tinnitus can be suppressed with intracochlear electrical stimulation independent of environmental sounds, even long term. No significant difference in tinnitus suppression was found between the standard clinical CI and the TI.
It can be concluded that coding of environmental sounds is no requirement for tinnitus suppression with intracochlear electrical stimulation. It is therefore plausible that tinnitus suppression by CI is not solely caused by an attention shift from the tinnitus to environmental sounds. Both the standard clinical CI and the experimental TI are potential treatment options for tinnitus. These findings offer perspectives for a successful clinical application of the TI, possibly even in patients with significant residual hearing.
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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Arts, Remo A G J</au><au>George, Erwin L J</au><au>Janssen, Miranda</au><au>Griessner, Andreas</au><au>Zierhofer, Clemens</au><au>Stokroos, Robert J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tinnitus Suppression by Intracochlear Electrical Stimulation in Single Sided Deafness - A Prospective Clinical Trial: Follow-Up</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2016-04-25</date><risdate>2016</risdate><volume>11</volume><issue>4</issue><spage>e0153131</spage><epage>e0153131</epage><pages>e0153131-e0153131</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Earlier studies show that a Cochlear Implant (CI), capable of providing intracochlear electrical stimulation independent of environmental sounds, appears to suppress tinnitus at least for minutes. The current main objective is to compare the long-term suppressive effects of looped (i.e. repeated) electrical stimulation (without environmental sound perception) with the standard stimulation pattern of a CI (with environmental sound perception). This could open new possibilities for the development of a "Tinnitus Implant" (TI), an intracochlear pulse generator for the suppression of tinnitus.
Ten patients with single sided deafness suffering from unilateral tinnitus in the deaf ear are fitted with a CI (MED-EL Corporation, Innsbruck, Austria). Stimulation patterns are optimized for each individual patient, after which they are compared using a randomized crossover design, with a follow-up of six months, followed by a 3 month period using the modality of patient's choice.
Results show that tinnitus can be suppressed with intracochlear electrical stimulation independent of environmental sounds, even long term. No significant difference in tinnitus suppression was found between the standard clinical CI and the TI.
It can be concluded that coding of environmental sounds is no requirement for tinnitus suppression with intracochlear electrical stimulation. It is therefore plausible that tinnitus suppression by CI is not solely caused by an attention shift from the tinnitus to environmental sounds. Both the standard clinical CI and the experimental TI are potential treatment options for tinnitus. These findings offer perspectives for a successful clinical application of the TI, possibly even in patients with significant residual hearing.
TrialRegister.nl NTR3374.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>27111333</pmid><doi>10.1371/journal.pone.0153131</doi><oa>free_for_read</oa></addata></record> |
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| issn | 1932-6203 1932-6203 |
| language | eng |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Acoustics Background noise Biology and Life Sciences Care and treatment Clinical trials Cochlea Cochlea - physiopathology Cochlear implants Cross-Over Studies Deafness Deafness - complications Deafness - physiopathology Ear Ears & hearing Electric Stimulation Electrical stimuli Engineering and Technology Hearing loss Humans Materials selection Medicine and Health Sciences Mental health Neurosciences Patient outcomes Patients Perception Prospective Studies Pulse generators Quality of life Rehabilitation Short term Social Sciences Stimulation Studies Surgery Systematic review Therapeutic applications Tinnitus Tinnitus - complications Tinnitus - prevention & control Transplants & implants Visual Analog Scale |
| title | Tinnitus Suppression by Intracochlear Electrical Stimulation in Single Sided Deafness - A Prospective Clinical Trial: Follow-Up |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T23%3A08%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Tinnitus%20Suppression%20by%20Intracochlear%20Electrical%20Stimulation%20in%20Single%20Sided%20Deafness%20-%20A%20Prospective%20Clinical%20Trial:%20Follow-Up&rft.jtitle=PloS%20one&rft.au=Arts,%20Remo%20A%20G%20J&rft.date=2016-04-25&rft.volume=11&rft.issue=4&rft.spage=e0153131&rft.epage=e0153131&rft.pages=e0153131-e0153131&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0153131&rft_dat=%3Cgale_plos_%3EA453426628%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1784084627&rft_id=info:pmid/27111333&rft_galeid=A453426628&rft_doaj_id=oai_doaj_org_article_493d07df573d446d86612ed11ddb865d&rfr_iscdi=true |