Nox4 and Duox1/2 Mediate Redox Activation of Mesenchymal Cell Migration by PDGF

Platelet derived growth factor (PDGF) orchestrates wound healing and tissue regeneration by regulating recruitment of the precursor mesenchymal stromal cells (MSC) and fibroblasts. PDGF stimulates generation of hydrogen peroxide that is required for cell migration, but the sources and intracellular...

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Veröffentlicht in:	PloS one 2016-04, Vol.11 (4), p.e0154157-e0154157
Hauptverfasser:	Tyurin-Kuzmin, Pyotr A, Zhdanovskaya, Nadezhda D, Sukhova, Anna A, Sagaradze, George D, Albert, Eugene A, Ageeva, Ludmila V, Sharonov, George V, Vorotnikov, Alexander V, Tkachuk, Vsevolod A
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Acetophenones - pharmacology Activation AKT protein Animals Biochemistry Biology and Life Sciences Cardiology Catalase Cell activation Cell adhesion & migration Cell culture Cell cycle Cell migration Cell Movement - drug effects Chromones - pharmacology Dual Oxidases Epidermal growth factor Extracellular signal-regulated kinase Fibroblasts Gene Expression Regulation HEK293 Cells Humans Hydrogen Hydrogen peroxide Hydrogen Peroxide - metabolism Intracellular Kinases Medicine Medicine and Health Sciences Mesenchymal Stem Cells - cytology Mesenchymal Stem Cells - drug effects Mesenchymal Stem Cells - metabolism Mesenchyme Mice Mitogen-Activated Protein Kinase 1 - genetics Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - genetics Mitogen-Activated Protein Kinase 3 - metabolism Morpholines - pharmacology NADPH Oxidase 4 NADPH Oxidases - antagonists & inhibitors NADPH Oxidases - genetics NADPH Oxidases - metabolism NIH 3T3 Cells NOX4 protein Oxidation-Reduction Oxidative stress Phosphatidylinositol 3-Kinase - genetics Phosphatidylinositol 3-Kinase - metabolism Phosphorylation Physical Sciences Platelet-derived growth factor Platelet-Derived Growth Factor - antagonists & inhibitors Platelet-Derived Growth Factor - pharmacology Primary Cell Culture Proteins Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Recruitment Regeneration Regeneration (Biology) Research and Analysis Methods RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Signal Transduction Signaling Smooth muscle Stem cells Stromal cells Tissue engineering Wound healing
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