High Mobility Group Box-1 Promotes Inflammation-Induced Lymphangiogenesis via Toll-Like Receptor 4-Dependent Signalling Pathway

Lymphangiogenesis in inflammation has received considerable attention in recent years. Administration of modulating lymphangiogenesis provides more possibilities of treating inflammation-associated diseases. However, the main mediators and factors governing inflammation-induced lymphangiogenesis (IL...

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Veröffentlicht in:	PloS one 2016-04, Vol.11 (4), p.e0154187-e0154187
Hauptverfasser:	Han, Longhui, Zhang, Minglian, Wang, Mengmeng, Jia, Jinchen, Zhao, Miying, Fan, Yiming, Li, Xiaorong
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Angiogenesis Animals Biology and Life Sciences Blotting, Western Cancer CD11b antigen Cell Line Cell lines Cell Proliferation - drug effects Cell Proliferation - genetics Cells, Cultured Cellular signal transduction Cornea Development and progression Endothelial Cells - cytology Endothelial Cells - metabolism Endothelium, Lymphatic - cytology Gelatinase A Gelatinase B Gene Expression Genetic aspects HMGB1 protein HMGB1 Protein - genetics HMGB1 Protein - metabolism IL-1β Immunoglobulins Inflammation Inflammation - genetics Inflammation - metabolism Interleukin-1beta - genetics Interleukin-1beta - metabolism Kinases Laboratories Lymphangiogenesis Macrophages - metabolism Male Medicine and Health Sciences Metastasis Mice Mice, Inbred C57BL Mice, Knockout Molecular modelling Neovascularization Neutrophils NF-κB protein Physiological aspects Research and Analysis Methods Reverse Transcriptase Polymerase Chain Reaction RNA Interference Signal Transduction Signaling TLR2 protein TLR4 protein Toll-Like Receptor 4 - genetics Toll-Like Receptor 4 - metabolism Toll-like receptors Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-α Vascular endothelial growth factor Vascular Endothelial Growth Factor C - genetics Vascular Endothelial Growth Factor C - metabolism Vascular endothelial growth factor receptors
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