OM-FBA: Integrate Transcriptomics Data with Flux Balance Analysis to Decipher the Cell Metabolism

Constraint-based metabolic modeling such as flux balance analysis (FBA) has been widely used to simulate cell metabolism. Thanks to its simplicity and flexibility, numerous algorithms have been developed based on FBA and successfully predicted the phenotypes of various biological systems. However, t...

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Veröffentlicht in:	PloS one 2016-04, Vol.11 (4), p.e0154188-e0154188
Hauptverfasser:	Guo, Weihua, Feng, Xueyang
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Algorithms Archives & records Biology and Life Sciences Cell metabolism Computer applications Computer simulation Constraint modelling Data collection Data processing Datasets Energy Metabolism - genetics Enzymes Ethanol Fluctuations Flux Fungi Galactose - metabolism Gene expression Gene Expression Profiling - methods Gene Expression Profiling - statistics & numerical data Gene Regulatory Networks Genetic aspects Genomes Genomics Genotype Glucose - metabolism Metabolic flux Metabolism Metabolites Metabolomics - methods Microorganisms Models, Genetic Noise Objective function Phenotype Physical Sciences Physiological aspects Predictions Proteins Proteomics Proteomics - methods Regression analysis Reproducibility of Results Research and Analysis Methods Saccharomyces cerevisiae Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - growth & development Saccharomyces cerevisiae - metabolism Standard deviation Sugar Systems Biology - methods Transcription (Genetics)
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