Comparative In Vivo Effects of Hemoglobin-Based Oxygen Carriers (HBOC) with Varying Prooxidant and Physiological Reactivity

A series of hemoglobin-based oxygen carrier candidates (HBOC), previously noted for their differences in prooxidative and physiological reactivity, were compared in terms of the negative effects displayed upon injection in Wistar rats. At the concentrations tested, antioxidant strategies based on al...

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Veröffentlicht in:	PloS one 2016-04, Vol.11 (4), p.e0153909-e0153909
Hauptverfasser:	Toma, Vlad Al, Farcaș, Anca D, Roman, Ioana, Sevastre, Bogdan, Hathazi, Denisa, Scurtu, Florina, Damian, Grigore, Silaghi-Dumitrescu, Radu
Format:	Artikel
Sprache:	eng
Schlagworte:	Albumin Animals Antioxidants Antioxidants (Nutrients) Biology and Life Sciences Blood Coagulation - drug effects Blood Glucose - metabolism Blood substitutes Blood Substitutes - adverse effects Blood Substitutes - pharmacology Cattle Chemical engineering Chemistry Clinical trials Glycosylated hemoglobin Hematologic Tests Hemoglobin Hemoglobins - adverse effects Hemoglobins - pharmacology Hydrogen peroxide Hypotheses Iron - metabolism Male Medicine and Health Sciences Oxidative stress Oxidative Stress - drug effects Oxygen Physical Sciences Physiological aspects Physiological effects Physiology Polyethylene glycol R&D Rats Rats, Wistar Reactive Oxygen Species - metabolism Research & development Transferrin - metabolism Veterinary medicine
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Zusammenfassung:	A series of hemoglobin-based oxygen carrier candidates (HBOC), previously noted for their differences in prooxidative and physiological reactivity, were compared in terms of the negative effects displayed upon injection in Wistar rats. At the concentrations tested, antioxidant strategies based on albumin as well as based on rubrerythrin appear to offer observable physiological advantages.
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0153909