Efficient Activation of Apoptotic Signaling during Mitotic Arrest with AK301

Mitotic inhibitors are widely utilized chemotherapeutic agents that take advantage of mitotic defects in cancer cells. We have identified a novel class of piperazine-based mitotic inhibitors, of which AK301 is the most potent derivative identified to date (EC50 < 200 nM). Colon cancer cells arres...

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Veröffentlicht in:	PloS one 2016-04, Vol.11 (4), p.e0153818-e0153818
Hauptverfasser:	Chopra, Avijeet, Bond, Michael J, Bleiler, Marina, Yeagley, Michelle, Wright, Dennis, Giardina, Charles
Format:	Artikel
Sprache:	eng
Schlagworte:	Aberration Activation Adenomatous polyposis coli Adenomatous Polyposis Coli Protein - genetics Amino acids Animals Antibiotics Apoptosis Apoptosis - drug effects Ataxia Telangiectasia Mutated Proteins - metabolism Aurora B protein Biology Biology and Life Sciences Breakage Cancer Cancer therapies Caspase 3 - metabolism Cell cycle Cell Cycle Checkpoints - drug effects Cellular signal transduction Chemotherapy Chromosomes Colchicine Colon Colon - cytology Colon cancer Colorectal cancer Damage Defects Deoxyribonucleic acid DNA DNA Breaks - drug effects DNA damage Genetic aspects HCT116 Cells HT29 Cells Humans Inhibitors Kinases Medical research Medicine and Health Sciences Mice Microtubules Mitosis Mitosis - drug effects Mutation p53 Protein Phosphorylation Physiological aspects Piperazine Piperazines - pharmacology Proteins Research and Analysis Methods Signaling Tubulin Tumor necrosis factor Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Vincristine
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