Anti-CD47 Treatment Stimulates Phagocytosis of Glioblastoma by M1 and M2 Polarized Macrophages and Promotes M1 Polarized Macrophages In Vivo

Tumor-associated macrophages (TAMs) represent an important cellular subset within the glioblastoma (WHO grade IV) microenvironment and are a potential therapeutic target. TAMs display a continuum of different polarization states between antitumorigenic M1 and protumorigenic M2 phenotypes, with a low...

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Veröffentlicht in:	PloS one 2016-04, Vol.11 (4), p.e0153550-e0153550
Hauptverfasser:	Zhang, Michael, Hutter, Gregor, Kahn, Suzana A, Azad, Tej D, Gholamin, Sharareh, Xu, Chelsea Y, Liu, Jie, Achrol, Achal S, Richard, Chase, Sommerkamp, Pia, Schoen, Matthew Kenneth, McCracken, Melissa N, Majeti, Ravi, Weissman, Irving, Mitra, Siddhartha S, Cheshier, Samuel H
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Antibodies - pharmacology Biology Biology and Life Sciences Bone marrow Brain cancer Brain research Care and treatment CD47 Antigen - metabolism Cell Differentiation - drug effects Cell Line, Tumor Cytometry Flow cytometry Glioblastoma Glioblastoma - drug therapy Glioblastoma - metabolism Glioblastoma - pathology Glioblastoma cells Glioblastomas Glioma Humans Integrins Macrophages Macrophages - drug effects Macrophages - metabolism Macrophages - pathology Medical research Medicine Medicine and Health Sciences Mice Mice, Inbred NOD Monoclonal antibodies Neurosurgery Ovarian cancer Pediatrics Peripheral blood Phagocytosis Phagocytosis - drug effects Phenotype Physicians Polarization Research and Analysis Methods Stem cells Tumors Xenografts Yang, Cindy
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