Bidirectional Association between Asthma and Irritable Bowel Syndrome: Two Population-Based Retrospective Cohort Studies
There is a demonstrated association between asthma and irritable bowel syndrome (IBS). In this study, we examined the bidirectional association between asthma and IBS using a nationwide database. We conducted two retrospective cohort studies using data obtained from the National Health Insurance of...
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| Veröffentlicht in: | PloS one 2016-04, Vol.11 (4), p.e0153911-e0153911 |
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| creator | Shen, Te-Chun Lin, Cheng-Li Wei, Chang-Ching Chen, Chia-Hung Tu, Chih-Yen Hsia, Te-Chun Shih, Chuen-Ming Hsu, Wu-Huei Sung, Fung-Chang Kao, Chia-Hung |
| description | There is a demonstrated association between asthma and irritable bowel syndrome (IBS). In this study, we examined the bidirectional association between asthma and IBS using a nationwide database.
We conducted two retrospective cohort studies using data obtained from the National Health Insurance of Taiwan. Study 1 included 29,648 asthma patients newly diagnosed between 2000 and 2010. Study 2 included 29,875 IBS patient newly diagnosed between 2000 and 2010. For each study, four subjects without asthma and IBS were selected, respectively, frequency-matched by sex, age, and the diagnosis date. All four cohorts were followed up until the end of 2011 to estimate incident IBS for Study 1 and incident asthma for study 2. Adjusted hazard ratios (aHRs) were estimated using the Cox proportional hazards model after controlling for sex, age and comorbidities.
The incidence of IBS was 1.89 times higher in the asthma cohort than in the comparison cohort (8.26 vs. 4.36 per 1,000 person-years), with an aHR of 1.57 [95% confidence interval (CI) = 1.47-1.68]. The aHRs remained significant in all subgroups measured by sex, age and the presence of comorbidities. In contrast, the incidence of asthma was 1.76 times higher in the IBS cohort than the comparison cohort (7.09 vs. 4.03 per 1,000 person-years), with an aHR of 1.54 (95% CI = 1.44-1.64). Similarly, aHRs remained significant in all subgroups measured by sex, age and the presence of comorbidities.
The present study suggests a bidirectional association between asthma and IBS. Atopy could be a shared pathophysiology underlying this association, deserving a further investigation. |
| doi_str_mv | 10.1371/journal.pone.0153911 |
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We conducted two retrospective cohort studies using data obtained from the National Health Insurance of Taiwan. Study 1 included 29,648 asthma patients newly diagnosed between 2000 and 2010. Study 2 included 29,875 IBS patient newly diagnosed between 2000 and 2010. For each study, four subjects without asthma and IBS were selected, respectively, frequency-matched by sex, age, and the diagnosis date. All four cohorts were followed up until the end of 2011 to estimate incident IBS for Study 1 and incident asthma for study 2. Adjusted hazard ratios (aHRs) were estimated using the Cox proportional hazards model after controlling for sex, age and comorbidities.
The incidence of IBS was 1.89 times higher in the asthma cohort than in the comparison cohort (8.26 vs. 4.36 per 1,000 person-years), with an aHR of 1.57 [95% confidence interval (CI) = 1.47-1.68]. The aHRs remained significant in all subgroups measured by sex, age and the presence of comorbidities. In contrast, the incidence of asthma was 1.76 times higher in the IBS cohort than the comparison cohort (7.09 vs. 4.03 per 1,000 person-years), with an aHR of 1.54 (95% CI = 1.44-1.64). Similarly, aHRs remained significant in all subgroups measured by sex, age and the presence of comorbidities.
The present study suggests a bidirectional association between asthma and IBS. Atopy could be a shared pathophysiology underlying this association, deserving a further investigation.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0153911</identifier><identifier>PMID: 27093172</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Age ; Age Factors ; Aged ; Allergies ; Analysis ; Asthma ; Asthma - epidemiology ; Asthma - etiology ; Atopy ; Bias ; Bidirectional ; Biology and Life Sciences ; Celiac disease ; Chronic obstructive pulmonary disease ; Codes ; Cohort analysis ; Complications and side effects ; Confidence intervals ; Databases, Factual ; Eczema ; Female ; Gastroesophageal reflux ; Hazards ; Health insurance ; Humans ; Incidence ; Intestine ; Irritable bowel syndrome ; Irritable Bowel Syndrome - epidemiology ; Irritable Bowel Syndrome - etiology ; Male ; Medicine and Health Sciences ; Middle Aged ; Nervous system ; Obesity ; Pathological physiology ; Patients ; Population ; Population studies ; Population-based studies ; Proportional Hazards Models ; Research and Analysis Methods ; Research Design ; Retrospective Studies ; Rhinitis ; Risk Factors ; Sex ; Social Sciences ; Statistical models ; Studies ; Subgroups ; Taiwan - epidemiology ; Young Adult</subject><ispartof>PloS one, 2016-04, Vol.11 (4), p.e0153911-e0153911</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Shen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2016 Shen et al 2016 Shen et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-bd1f0d9fe8935bf012829da275a79eb9a1c62b9c25e91080d68a4a4a28b3a7d33</citedby><cites>FETCH-LOGICAL-c692t-bd1f0d9fe8935bf012829da275a79eb9a1c62b9c25e91080d68a4a4a28b3a7d33</cites><orcidid>0000-0002-9427-1068</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836663/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836663/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2100,2919,23857,27915,27916,53782,53784,79361,79362</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27093172$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Kirk, Martyn</contributor><creatorcontrib>Shen, Te-Chun</creatorcontrib><creatorcontrib>Lin, Cheng-Li</creatorcontrib><creatorcontrib>Wei, Chang-Ching</creatorcontrib><creatorcontrib>Chen, Chia-Hung</creatorcontrib><creatorcontrib>Tu, Chih-Yen</creatorcontrib><creatorcontrib>Hsia, Te-Chun</creatorcontrib><creatorcontrib>Shih, Chuen-Ming</creatorcontrib><creatorcontrib>Hsu, Wu-Huei</creatorcontrib><creatorcontrib>Sung, Fung-Chang</creatorcontrib><creatorcontrib>Kao, Chia-Hung</creatorcontrib><title>Bidirectional Association between Asthma and Irritable Bowel Syndrome: Two Population-Based Retrospective Cohort Studies</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>There is a demonstrated association between asthma and irritable bowel syndrome (IBS). In this study, we examined the bidirectional association between asthma and IBS using a nationwide database.
We conducted two retrospective cohort studies using data obtained from the National Health Insurance of Taiwan. Study 1 included 29,648 asthma patients newly diagnosed between 2000 and 2010. Study 2 included 29,875 IBS patient newly diagnosed between 2000 and 2010. For each study, four subjects without asthma and IBS were selected, respectively, frequency-matched by sex, age, and the diagnosis date. All four cohorts were followed up until the end of 2011 to estimate incident IBS for Study 1 and incident asthma for study 2. Adjusted hazard ratios (aHRs) were estimated using the Cox proportional hazards model after controlling for sex, age and comorbidities.
The incidence of IBS was 1.89 times higher in the asthma cohort than in the comparison cohort (8.26 vs. 4.36 per 1,000 person-years), with an aHR of 1.57 [95% confidence interval (CI) = 1.47-1.68]. The aHRs remained significant in all subgroups measured by sex, age and the presence of comorbidities. In contrast, the incidence of asthma was 1.76 times higher in the IBS cohort than the comparison cohort (7.09 vs. 4.03 per 1,000 person-years), with an aHR of 1.54 (95% CI = 1.44-1.64). Similarly, aHRs remained significant in all subgroups measured by sex, age and the presence of comorbidities.
The present study suggests a bidirectional association between asthma and IBS. Atopy could be a shared pathophysiology underlying this association, deserving a further investigation.</description><subject>Adult</subject><subject>Age</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Allergies</subject><subject>Analysis</subject><subject>Asthma</subject><subject>Asthma - epidemiology</subject><subject>Asthma - etiology</subject><subject>Atopy</subject><subject>Bias</subject><subject>Bidirectional</subject><subject>Biology and Life Sciences</subject><subject>Celiac disease</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Codes</subject><subject>Cohort analysis</subject><subject>Complications and side effects</subject><subject>Confidence intervals</subject><subject>Databases, Factual</subject><subject>Eczema</subject><subject>Female</subject><subject>Gastroesophageal reflux</subject><subject>Hazards</subject><subject>Health insurance</subject><subject>Humans</subject><subject>Incidence</subject><subject>Intestine</subject><subject>Irritable bowel syndrome</subject><subject>Irritable Bowel Syndrome - epidemiology</subject><subject>Irritable Bowel Syndrome - etiology</subject><subject>Male</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Nervous system</subject><subject>Obesity</subject><subject>Pathological physiology</subject><subject>Patients</subject><subject>Population</subject><subject>Population studies</subject><subject>Population-based studies</subject><subject>Proportional Hazards Models</subject><subject>Research and Analysis Methods</subject><subject>Research Design</subject><subject>Retrospective Studies</subject><subject>Rhinitis</subject><subject>Risk Factors</subject><subject>Sex</subject><subject>Social Sciences</subject><subject>Statistical models</subject><subject>Studies</subject><subject>Subgroups</subject><subject>Taiwan - epidemiology</subject><subject>Young Adult</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk0uP0zAQxyMEYpfCN0AQCQnBocWPvMwBqa14VFpp0XbhajnxpHXlxsV2trvfHqfNrhq0B-SD4_Fv_jOezETRa4wmmOb408a0thF6sjMNTBBOKcP4SXSOGSXjjCD69OT7LHrh3AahlBZZ9jw6IzliFOfkPLqdKaksVF6ZIBZPnTOVEt0pLsHvAZpg8-utiEUj44W1yotSQzwze9Dx8q6R1mzhc3y9N_FPs2v1wXc8Ew5kfAXeGrfr1G8gnpu1sT5e-lYqcC-jZ7XQDl71-yj69e3r9fzH-OLy-2I-vRhXGSN-XEpcI8lqKBhNyxphUhAmBclTkTMomcBVRkpWkRQYRgWSWSGSsEhRUpFLSkfR26PuThvH-6I5jvOCkFCPLAvE4khIIzZ8Z9VW2DtuhOIHg7ErLqxXlQYuixqxDPIQJU_SWgqKRZkArvK6rAuaBK0vfbS23IKsoPFW6IHo8KZRa74yNzwpQipZl-6HXsCaPy04z7fKVaC1aMC0h7wpTTAL5RhF7_5BH39dT61EeIBqahPiVp0onyYpTZKckTRQk0eosCRsVRU6rFbBPnD4OHAIjIdbvxKtc3yxvPp_9vL3kH1_wq5BaL92RrddV7khmBzBKrSYs1A_FBkj3g3IfTV4NyC8H5Dg9ub0Bz043U8E_QuX5Aza</recordid><startdate>20160419</startdate><enddate>20160419</enddate><creator>Shen, Te-Chun</creator><creator>Lin, Cheng-Li</creator><creator>Wei, Chang-Ching</creator><creator>Chen, Chia-Hung</creator><creator>Tu, Chih-Yen</creator><creator>Hsia, Te-Chun</creator><creator>Shih, Chuen-Ming</creator><creator>Hsu, Wu-Huei</creator><creator>Sung, Fung-Chang</creator><creator>Kao, Chia-Hung</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-9427-1068</orcidid></search><sort><creationdate>20160419</creationdate><title>Bidirectional Association between Asthma and Irritable Bowel Syndrome: Two Population-Based Retrospective Cohort Studies</title><author>Shen, Te-Chun ; Lin, Cheng-Li ; Wei, Chang-Ching ; Chen, Chia-Hung ; Tu, Chih-Yen ; Hsia, Te-Chun ; Shih, Chuen-Ming ; Hsu, Wu-Huei ; Sung, Fung-Chang ; Kao, Chia-Hung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-bd1f0d9fe8935bf012829da275a79eb9a1c62b9c25e91080d68a4a4a28b3a7d33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Age</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Allergies</topic><topic>Analysis</topic><topic>Asthma</topic><topic>Asthma - epidemiology</topic><topic>Asthma - etiology</topic><topic>Atopy</topic><topic>Bias</topic><topic>Bidirectional</topic><topic>Biology and Life Sciences</topic><topic>Celiac disease</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Codes</topic><topic>Cohort analysis</topic><topic>Complications and side effects</topic><topic>Confidence intervals</topic><topic>Databases, Factual</topic><topic>Eczema</topic><topic>Female</topic><topic>Gastroesophageal reflux</topic><topic>Hazards</topic><topic>Health insurance</topic><topic>Humans</topic><topic>Incidence</topic><topic>Intestine</topic><topic>Irritable bowel syndrome</topic><topic>Irritable Bowel Syndrome - epidemiology</topic><topic>Irritable Bowel Syndrome - etiology</topic><topic>Male</topic><topic>Medicine and Health Sciences</topic><topic>Middle Aged</topic><topic>Nervous system</topic><topic>Obesity</topic><topic>Pathological physiology</topic><topic>Patients</topic><topic>Population</topic><topic>Population studies</topic><topic>Population-based studies</topic><topic>Proportional Hazards Models</topic><topic>Research and Analysis Methods</topic><topic>Research Design</topic><topic>Retrospective Studies</topic><topic>Rhinitis</topic><topic>Risk Factors</topic><topic>Sex</topic><topic>Social Sciences</topic><topic>Statistical models</topic><topic>Studies</topic><topic>Subgroups</topic><topic>Taiwan - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shen, Te-Chun</au><au>Lin, Cheng-Li</au><au>Wei, Chang-Ching</au><au>Chen, Chia-Hung</au><au>Tu, Chih-Yen</au><au>Hsia, Te-Chun</au><au>Shih, Chuen-Ming</au><au>Hsu, Wu-Huei</au><au>Sung, Fung-Chang</au><au>Kao, Chia-Hung</au><au>Kirk, Martyn</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bidirectional Association between Asthma and Irritable Bowel Syndrome: Two Population-Based Retrospective Cohort Studies</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2016-04-19</date><risdate>2016</risdate><volume>11</volume><issue>4</issue><spage>e0153911</spage><epage>e0153911</epage><pages>e0153911-e0153911</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>There is a demonstrated association between asthma and irritable bowel syndrome (IBS). In this study, we examined the bidirectional association between asthma and IBS using a nationwide database.
We conducted two retrospective cohort studies using data obtained from the National Health Insurance of Taiwan. Study 1 included 29,648 asthma patients newly diagnosed between 2000 and 2010. Study 2 included 29,875 IBS patient newly diagnosed between 2000 and 2010. For each study, four subjects without asthma and IBS were selected, respectively, frequency-matched by sex, age, and the diagnosis date. All four cohorts were followed up until the end of 2011 to estimate incident IBS for Study 1 and incident asthma for study 2. Adjusted hazard ratios (aHRs) were estimated using the Cox proportional hazards model after controlling for sex, age and comorbidities.
The incidence of IBS was 1.89 times higher in the asthma cohort than in the comparison cohort (8.26 vs. 4.36 per 1,000 person-years), with an aHR of 1.57 [95% confidence interval (CI) = 1.47-1.68]. The aHRs remained significant in all subgroups measured by sex, age and the presence of comorbidities. In contrast, the incidence of asthma was 1.76 times higher in the IBS cohort than the comparison cohort (7.09 vs. 4.03 per 1,000 person-years), with an aHR of 1.54 (95% CI = 1.44-1.64). Similarly, aHRs remained significant in all subgroups measured by sex, age and the presence of comorbidities.
The present study suggests a bidirectional association between asthma and IBS. Atopy could be a shared pathophysiology underlying this association, deserving a further investigation.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>27093172</pmid><doi>10.1371/journal.pone.0153911</doi><orcidid>https://orcid.org/0000-0002-9427-1068</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2016-04, Vol.11 (4), p.e0153911-e0153911 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1782205366 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adult Age Age Factors Aged Allergies Analysis Asthma Asthma - epidemiology Asthma - etiology Atopy Bias Bidirectional Biology and Life Sciences Celiac disease Chronic obstructive pulmonary disease Codes Cohort analysis Complications and side effects Confidence intervals Databases, Factual Eczema Female Gastroesophageal reflux Hazards Health insurance Humans Incidence Intestine Irritable bowel syndrome Irritable Bowel Syndrome - epidemiology Irritable Bowel Syndrome - etiology Male Medicine and Health Sciences Middle Aged Nervous system Obesity Pathological physiology Patients Population Population studies Population-based studies Proportional Hazards Models Research and Analysis Methods Research Design Retrospective Studies Rhinitis Risk Factors Sex Social Sciences Statistical models Studies Subgroups Taiwan - epidemiology Young Adult |
| title | Bidirectional Association between Asthma and Irritable Bowel Syndrome: Two Population-Based Retrospective Cohort Studies |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T05%3A14%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Bidirectional%20Association%20between%20Asthma%20and%20Irritable%20Bowel%20Syndrome:%20Two%20Population-Based%20Retrospective%20Cohort%20Studies&rft.jtitle=PloS%20one&rft.au=Shen,%20Te-Chun&rft.date=2016-04-19&rft.volume=11&rft.issue=4&rft.spage=e0153911&rft.epage=e0153911&rft.pages=e0153911-e0153911&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0153911&rft_dat=%3Cgale_plos_%3EA453447925%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1782205366&rft_id=info:pmid/27093172&rft_galeid=A453447925&rft_doaj_id=oai_doaj_org_article_d8f096e7d68745fda31ab4e1c7fbf834&rfr_iscdi=true |