MiR144/451 Expression Is Repressed by RUNX1 During Megakaryopoiesis and Disturbed by RUNX1/ETO

A network of lineage-specific transcription factors and microRNAs tightly regulates differentiation of hematopoietic stem cells along the distinct lineages. Deregulation of this regulatory network contributes to impaired lineage fidelity and leukemogenesis. We found that the hematopoietic master reg...

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Veröffentlicht in:	PLoS genetics 2016-03, Vol.12 (3), p.e1005946-e1005946
Hauptverfasser:	Kohrs, Nicole, Kolodziej, Stephan, Kuvardina, Olga N, Herglotz, Julia, Yillah, Jasmin, Herkt, Stefanie, Piechatzek, Alexander, Salinas Riester, Gabriela, Lingner, Thomas, Wichmann, Christian, Bonig, Halvard, Seifried, Erhard, Platzbecker, Uwe, Medyouf, Hind, Grez, Manuel, Lausen, Jörn
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute myelocytic leukemia Biology and life sciences Cell Differentiation - genetics Cell Lineage Cloning Core Binding Factor Alpha 2 Subunit - biosynthesis Core Binding Factor Alpha 2 Subunit - genetics Epigenetics Experiments Gene expression Gene Expression Regulation, Leukemic Gene Regulatory Networks - genetics Genetic aspects Health aspects Hematopoietic stem cells Humans Leukemia Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - pathology Medicine and Health Sciences Megakaryocytes - cytology MicroRNA MicroRNAs MicroRNAs - biosynthesis MicroRNAs - genetics Mutation Oncogene Proteins, Fusion - biosynthesis Oncogene Proteins, Fusion - genetics Proteins Research and analysis methods Transcription factors
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