Genome-Wide Pharmacogenomic Study on Methadone Maintenance Treatment Identifies SNP rs17180299 and Multiple Haplotypes on CYP2B6, SPON1, and GSG1L Associated with Plasma Concentrations of Methadone R- and S-enantiomers in Heroin-Dependent Patients

Methadone maintenance treatment (MMT) is commonly used for controlling opioid dependence, preventing withdrawal symptoms, and improving the quality of life of heroin-dependent patients. A steady-state plasma concentration of methadone enantiomers, a measure of methadone metabolism, is an index of tr...

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Veröffentlicht in:	PLoS genetics 2016-03, Vol.12 (3), p.e1005910-e1005910
Hauptverfasser:	Yang, Hsin-Chou, Chu, Shih-Kai, Huang, Chieh-Liang, Kuo, Hsiang-Wei, Wang, Sheng-Chang, Liu, Sheng-Wen, Ho, Ing-Kang, Liu, Yu-Li
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Androstanes - metabolism Biology and Life Sciences Care and treatment Complications and side effects Cytochrome P-450 CYP2B6 - genetics Drug abuse Engineering and Technology Extracellular Matrix Proteins - genetics Female Genetic aspects Genome-wide association studies Genome-Wide Association Study Haplotypes - genetics Health aspects Heroin Heroin - metabolism Heroin - toxicity Heroin Dependence - genetics Heroin Dependence - metabolism Heroin Dependence - pathology Humans Male Medical research Medicine and Health Sciences Metabolites Methadone Methadone - administration & dosage Methadone - metabolism Middle Aged Observations Opiate Substitution Treatment Pharmacogenetics Pharmacogenomics Plasma Polymorphism, Single Nucleotide Research and Analysis Methods Single nucleotide polymorphisms Stereoisomerism
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