An Ancient Fingerprint Indicates the Common Ancestry of Rossmann-Fold Enzymes Utilizing Different Ribose-Based Cofactors

Nucleoside-based cofactors are presumed to have preceded proteins. The Rossmann fold is one of the most ancient and functionally diverse protein folds, and most Rossmann enzymes utilize nucleoside-based cofactors. We analyzed an omnipresent Rossmann ribose-binding interaction: a carboxylate side cha...

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Veröffentlicht in:	PLoS biology 2016-03, Vol.14 (3), p.e1002396-e1002396
Hauptverfasser:	Laurino, Paola, Tóth-Petróczy, Ágnes, Meana-Pañeda, Rubén, Lin, Wei, Truhlar, Donald G, Tawfik, Dan S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Biology and Life Sciences Coenzymes Dehydrogenases Enzyme kinetics Enzymes Enzymes - genetics Evolution Evolution, Molecular Genealogy Geometry Observations Physical Sciences Proteins Research and Analysis Methods Ribose - metabolism Structure-Activity Relationship
Online-Zugang:	Volltext
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