An Interferon Regulated MicroRNA Provides Broad Cell-Intrinsic Antiviral Immunity through Multihit Host-Directed Targeting of the Sterol Pathway

In invertebrates, small interfering RNAs are at the vanguard of cell-autonomous antiviral immunity. In contrast, antiviral mechanisms initiated by interferon (IFN) signaling predominate in mammals. Whilst mammalian IFN-induced miRNA are known to inhibit specific viruses, it is not known whether host...

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Veröffentlicht in:	PLoS biology 2016-03, Vol.14 (3), p.e1002364
Hauptverfasser:	Robertson, Kevin A, Hsieh, Wei Yuan, Forster, Thorsten, Blanc, Mathieu, Lu, Hongjin, Crick, Peter J, Yutuc, Eylan, Watterson, Steven, Martin, Kimberly, Griffiths, Samantha J, Enright, Anton J, Yamamoto, Mami, Pradeepa, Madapura M, Lennox, Kimberly A, Behlke, Mark A, Talbot, Simon, Haas, Jürgen, Dölken, Lars, Griffiths, William J, Wang, Yuqin, Angulo, Ana, Ghazal, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding sites Biology and life sciences Biosynthesis Cholesterol Cytomegalovirus Experiments Gene expression Infections Influenza Interferon Interferon Regulatory Factor-1 - metabolism Interferons - physiology Kinases Mammals Metabolism Metabolites Methods Mice, Inbred C57BL MicroRNA MicroRNAs MicroRNAs - metabolism Physiological aspects RNA sequencing Sterols Sterols - biosynthesis Viral infections Virus Diseases - immunology Viruses
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