Identification of BRCA1 Deficiency Using Multi-Analyte Estimation of BRCA1 and Its Repressors in FFPE Tumor Samples from Patients with Triple Negative Breast Cancer

Apart from germ-line BRCA1-mutated breast cancers, a significant proportion of women with sporadic triple negative breast cancer (TNBC) sub-type are known to harbour varying levels of BRCA1-dysfuction. There is currently no established diagnostic method to identify these patients. The analysis was p...

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Veröffentlicht in:	PloS one 2016-04, Vol.11 (4), p.e0153113-e0153113
Hauptverfasser:	Korlimarla, Aruna, Prabhu, Jyothi S, Remacle, Jose, Rajarajan, Savitha, Raja, Uma, C E, Anupama, Srinath, B S, Manjunath, Suraj, K S, Gopinath, Correa, Marjorrie, M S N, Prasad, Sridhar, T S
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Biology and life sciences Biomarkers BRCA mutations BRCA1 protein BRCA1 Protein - deficiency BRCA1 Protein - genetics Breast cancer Cancer Cancer therapies Carboplatin - pharmacology Carboplatin - therapeutic use Development and progression Diagnostic systems DNA repair ErbB-2 protein Ethics Female Formaldehyde Gene Expression Regulation, Neoplastic - drug effects Genetic aspects Genotype & phenotype Hospitals Humans Identification Identification methods Inhibitor of Differentiation Proteins - genetics Medical research Medicine Medicine and Health Sciences MicroRNAs - genetics Middle Aged miRNA Mutation Neoplasm Staging Oncology Ovarian cancer Paraffin Paraffin Embedding Pathology Patients Physiological aspects Repressors Research and analysis methods RNA, Messenger - genetics RNA, Messenger - metabolism Tissue Fixation Transcription Treatment Outcome Triple Negative Breast Neoplasms - drug therapy Triple Negative Breast Neoplasms - genetics Triple Negative Breast Neoplasms - metabolism Triple Negative Breast Neoplasms - pathology Tumors
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