Differential Post-Exercise Blood Pressure Responses between Blacks and Caucasians
Post-exercise hypotension (PEH) is widely observed in Caucasians (CA) and is associated with histamine receptors 1- and 2- (H1R and H2R) mediated post-exercise vasodilation. However, it appears that blacks (BL) may not exhibit PEH following aerobic exercise. Hence, this study sought to determine the...
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| creator | Yan, Huimin Behun, Michael A Cook, Marc D Ranadive, Sushant M Lane-Cordova, Abbi D Kappus, Rebecca M Woods, Jeffrey A Wilund, Kenneth R Baynard, Tracy Halliwill, John R Fernhall, Bo |
| description | Post-exercise hypotension (PEH) is widely observed in Caucasians (CA) and is associated with histamine receptors 1- and 2- (H1R and H2R) mediated post-exercise vasodilation. However, it appears that blacks (BL) may not exhibit PEH following aerobic exercise. Hence, this study sought to determine the extent to which BL develop PEH, and the contribution of histamine receptors to PEH (or lack thereof) in this population. Forty-nine (22 BL, 27 CA) young and healthy subjects completed the study. Subjects were randomly assigned to take either a combined H1R and H2R antagonist (fexofenadine and ranitidine) or a control placebo. Supine blood pressure (BP), cardiac output and peripheral vascular resistance measurements were obtained at baseline, as well as at 30 min, 60 min and 90 min after 45 min of treadmill exercise at 70% heart rate reserve. Exercise increased diastolic BP in young BL but not in CA. Post-exercise diastolic BP was also elevated in BL after exercise with histamine receptor blockade. Moreover, H1R and H2R blockade elicited differential responses in stroke volume between BL and CA at rest, and the difference remained following exercise. Our findings show differential BP responses following exercise in BL and CA, and a potential role of histamine receptors in mediating basal and post-exercise stroke volume in BL. The heightened BP and vascular responses to exercise stimulus is consistent with the greater CVD risk in BL. |
| doi_str_mv | 10.1371/journal.pone.0153445 |
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However, it appears that blacks (BL) may not exhibit PEH following aerobic exercise. Hence, this study sought to determine the extent to which BL develop PEH, and the contribution of histamine receptors to PEH (or lack thereof) in this population. Forty-nine (22 BL, 27 CA) young and healthy subjects completed the study. Subjects were randomly assigned to take either a combined H1R and H2R antagonist (fexofenadine and ranitidine) or a control placebo. Supine blood pressure (BP), cardiac output and peripheral vascular resistance measurements were obtained at baseline, as well as at 30 min, 60 min and 90 min after 45 min of treadmill exercise at 70% heart rate reserve. Exercise increased diastolic BP in young BL but not in CA. Post-exercise diastolic BP was also elevated in BL after exercise with histamine receptor blockade. Moreover, H1R and H2R blockade elicited differential responses in stroke volume between BL and CA at rest, and the difference remained following exercise. Our findings show differential BP responses following exercise in BL and CA, and a potential role of histamine receptors in mediating basal and post-exercise stroke volume in BL. The heightened BP and vascular responses to exercise stimulus is consistent with the greater CVD risk in BL.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0153445</identifier><identifier>PMID: 27074034</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Adult ; Aerobic exercises ; African Continental Ancestry Group ; Biology and Life Sciences ; Blacks ; Blood ; Blood pressure ; Blood Pressure - drug effects ; Blood Pressure - physiology ; Cardiac output ; Cardiology ; Cardiovascular disease ; Care and treatment ; Community ; Diagnosis ; Double-Blind Method ; European Continental Ancestry Group ; Exercise ; Exercise - physiology ; Female ; Fexofenadine ; Health aspects ; Heart diseases ; Heart rate ; Heart Rate - drug effects ; Heart Rate - physiology ; Histamine ; Histamine H1 Antagonists - pharmacology ; Histamine H2 Antagonists - pharmacology ; Histamine receptors ; Humans ; Hypertension ; Hypotension ; Kidney diseases ; Kinesiology ; Leg - blood supply ; Male ; Medicine and Health Sciences ; Mens health ; Metabolism ; Nutrition ; Oxygen Consumption - drug effects ; Oxygen Consumption - physiology ; Physical fitness ; Physical Sciences ; Physical training ; Ranitidine ; Ranitidine - pharmacology ; Receptors ; Regional Blood Flow - drug effects ; Regional Blood Flow - physiology ; Risk factors ; Stroke ; Stroke volume ; Terfenadine - analogs & derivatives ; Terfenadine - pharmacology ; Vascular Resistance - drug effects ; Vascular Resistance - physiology ; Vasodilation ; Womens health ; Young Adult</subject><ispartof>PloS one, 2016-04, Vol.11 (4), p.e0153445-e0153445</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Yan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2016 Yan et al 2016 Yan et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c725t-1759491dfa5008ba6e5884e243b79461643f67c0c836efd39ebd3280f662a84e3</citedby><cites>FETCH-LOGICAL-c725t-1759491dfa5008ba6e5884e243b79461643f67c0c836efd39ebd3280f662a84e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830622/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830622/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2100,2919,23857,27915,27916,53782,53784,79361,79362</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27074034$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Raleigh, Stuart</contributor><creatorcontrib>Yan, Huimin</creatorcontrib><creatorcontrib>Behun, Michael A</creatorcontrib><creatorcontrib>Cook, Marc D</creatorcontrib><creatorcontrib>Ranadive, Sushant M</creatorcontrib><creatorcontrib>Lane-Cordova, Abbi D</creatorcontrib><creatorcontrib>Kappus, Rebecca M</creatorcontrib><creatorcontrib>Woods, Jeffrey A</creatorcontrib><creatorcontrib>Wilund, Kenneth R</creatorcontrib><creatorcontrib>Baynard, Tracy</creatorcontrib><creatorcontrib>Halliwill, John R</creatorcontrib><creatorcontrib>Fernhall, Bo</creatorcontrib><title>Differential Post-Exercise Blood Pressure Responses between Blacks and Caucasians</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Post-exercise hypotension (PEH) is widely observed in Caucasians (CA) and is associated with histamine receptors 1- and 2- (H1R and H2R) mediated post-exercise vasodilation. However, it appears that blacks (BL) may not exhibit PEH following aerobic exercise. Hence, this study sought to determine the extent to which BL develop PEH, and the contribution of histamine receptors to PEH (or lack thereof) in this population. Forty-nine (22 BL, 27 CA) young and healthy subjects completed the study. Subjects were randomly assigned to take either a combined H1R and H2R antagonist (fexofenadine and ranitidine) or a control placebo. Supine blood pressure (BP), cardiac output and peripheral vascular resistance measurements were obtained at baseline, as well as at 30 min, 60 min and 90 min after 45 min of treadmill exercise at 70% heart rate reserve. Exercise increased diastolic BP in young BL but not in CA. Post-exercise diastolic BP was also elevated in BL after exercise with histamine receptor blockade. Moreover, H1R and H2R blockade elicited differential responses in stroke volume between BL and CA at rest, and the difference remained following exercise. Our findings show differential BP responses following exercise in BL and CA, and a potential role of histamine receptors in mediating basal and post-exercise stroke volume in BL. The heightened BP and vascular responses to exercise stimulus is consistent with the greater CVD risk in BL.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aerobic exercises</subject><subject>African Continental Ancestry Group</subject><subject>Biology and Life Sciences</subject><subject>Blacks</subject><subject>Blood</subject><subject>Blood pressure</subject><subject>Blood Pressure - drug effects</subject><subject>Blood Pressure - physiology</subject><subject>Cardiac output</subject><subject>Cardiology</subject><subject>Cardiovascular disease</subject><subject>Care and treatment</subject><subject>Community</subject><subject>Diagnosis</subject><subject>Double-Blind Method</subject><subject>European Continental Ancestry Group</subject><subject>Exercise</subject><subject>Exercise - physiology</subject><subject>Female</subject><subject>Fexofenadine</subject><subject>Health aspects</subject><subject>Heart diseases</subject><subject>Heart rate</subject><subject>Heart Rate - drug effects</subject><subject>Heart Rate - physiology</subject><subject>Histamine</subject><subject>Histamine H1 Antagonists - pharmacology</subject><subject>Histamine H2 Antagonists - pharmacology</subject><subject>Histamine receptors</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypotension</subject><subject>Kidney diseases</subject><subject>Kinesiology</subject><subject>Leg - blood supply</subject><subject>Male</subject><subject>Medicine and Health Sciences</subject><subject>Mens health</subject><subject>Metabolism</subject><subject>Nutrition</subject><subject>Oxygen Consumption - drug effects</subject><subject>Oxygen Consumption - physiology</subject><subject>Physical fitness</subject><subject>Physical Sciences</subject><subject>Physical training</subject><subject>Ranitidine</subject><subject>Ranitidine - pharmacology</subject><subject>Receptors</subject><subject>Regional Blood Flow - drug effects</subject><subject>Regional Blood Flow - physiology</subject><subject>Risk factors</subject><subject>Stroke</subject><subject>Stroke volume</subject><subject>Terfenadine - analogs & derivatives</subject><subject>Terfenadine - pharmacology</subject><subject>Vascular Resistance - drug effects</subject><subject>Vascular Resistance - physiology</subject><subject>Vasodilation</subject><subject>Womens health</subject><subject>Young Adult</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk1tv0zAUxyMEYmPwDRBEQkLw0OJbbOcFaZSxVZq0MS6vlmOftC5pXOwExrfHpdnUoEkgP9g6_p3_sc8ly55iNMVU4Dcr34dWN9ONb2GKcEEZK-5lh7ikZMIJovf3zgfZoxhXCBVUcv4wOyACCYYoO8w-vnd1DQHazukmv_Sxm5xcQzAuQv6u8d7mlwFi7APkVxBTrAgxr6D7CdAmQJtvMdetzWe6Nzo63cbH2YNaNxGeDPtR9uXDyefZ2eT84nQ-Oz6fGEGKboJFUbIS21oXCMlKcyikZEAYrUTJOOaM1lwYZCTlUFtaQmUpkajmnOgE0qPs-U530_iohmxEhYVEEnFKy0TMd4T1eqU2wa11-KW8duqPwYeF0qFzpgGFS404SkErK5k1qCwqApUWVJPCGmmT1tshWl-twZqUsKCbkej4pnVLtfA_FJMUcUKSwKtBIPjvPcROrV000DS6Bd-nd8tSUFFgiv6NCpnKzZNsQl_8hd6diIFa6PRX19Y-PdFsRdUx2zaOJCVN1PQOKi0La2dSl9Uu2UcOr0cOiengulvoPkY1_3T1_-zF1zH7co9dgm66ZfRN37nUfmOQ7UATfIwB6tt6YKS2Q3KTDbUdEjUMSXJ7tl_LW6ebqaC_AfRhCno</recordid><startdate>20160413</startdate><enddate>20160413</enddate><creator>Yan, Huimin</creator><creator>Behun, Michael A</creator><creator>Cook, Marc D</creator><creator>Ranadive, Sushant M</creator><creator>Lane-Cordova, Abbi D</creator><creator>Kappus, Rebecca M</creator><creator>Woods, Jeffrey A</creator><creator>Wilund, Kenneth R</creator><creator>Baynard, Tracy</creator><creator>Halliwill, John R</creator><creator>Fernhall, Bo</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>7TS</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20160413</creationdate><title>Differential Post-Exercise Blood Pressure Responses between Blacks and Caucasians</title><author>Yan, Huimin ; Behun, Michael A ; Cook, Marc D ; Ranadive, Sushant M ; Lane-Cordova, Abbi D ; Kappus, Rebecca M ; Woods, Jeffrey A ; Wilund, Kenneth R ; Baynard, Tracy ; Halliwill, John R ; Fernhall, Bo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c725t-1759491dfa5008ba6e5884e243b79461643f67c0c836efd39ebd3280f662a84e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aerobic exercises</topic><topic>African Continental Ancestry Group</topic><topic>Biology and Life Sciences</topic><topic>Blacks</topic><topic>Blood</topic><topic>Blood pressure</topic><topic>Blood Pressure - 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Academic</collection><collection>Physical Education Index</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yan, Huimin</au><au>Behun, Michael A</au><au>Cook, Marc D</au><au>Ranadive, Sushant M</au><au>Lane-Cordova, Abbi D</au><au>Kappus, Rebecca M</au><au>Woods, Jeffrey A</au><au>Wilund, Kenneth R</au><au>Baynard, Tracy</au><au>Halliwill, John R</au><au>Fernhall, Bo</au><au>Raleigh, Stuart</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential Post-Exercise Blood Pressure Responses between Blacks and Caucasians</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2016-04-13</date><risdate>2016</risdate><volume>11</volume><issue>4</issue><spage>e0153445</spage><epage>e0153445</epage><pages>e0153445-e0153445</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Post-exercise hypotension (PEH) is widely observed in Caucasians (CA) and is associated with histamine receptors 1- and 2- (H1R and H2R) mediated post-exercise vasodilation. However, it appears that blacks (BL) may not exhibit PEH following aerobic exercise. Hence, this study sought to determine the extent to which BL develop PEH, and the contribution of histamine receptors to PEH (or lack thereof) in this population. Forty-nine (22 BL, 27 CA) young and healthy subjects completed the study. Subjects were randomly assigned to take either a combined H1R and H2R antagonist (fexofenadine and ranitidine) or a control placebo. Supine blood pressure (BP), cardiac output and peripheral vascular resistance measurements were obtained at baseline, as well as at 30 min, 60 min and 90 min after 45 min of treadmill exercise at 70% heart rate reserve. Exercise increased diastolic BP in young BL but not in CA. Post-exercise diastolic BP was also elevated in BL after exercise with histamine receptor blockade. Moreover, H1R and H2R blockade elicited differential responses in stroke volume between BL and CA at rest, and the difference remained following exercise. Our findings show differential BP responses following exercise in BL and CA, and a potential role of histamine receptors in mediating basal and post-exercise stroke volume in BL. The heightened BP and vascular responses to exercise stimulus is consistent with the greater CVD risk in BL.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>27074034</pmid><doi>10.1371/journal.pone.0153445</doi><tpages>e0153445</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
| recordid | cdi_plos_journals_1780806339 |
| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; PubMed; Free Full-Text Journals in Chemistry; EZB Electronic Journals Library |
| subjects | Adolescent Adult Aerobic exercises African Continental Ancestry Group Biology and Life Sciences Blacks Blood Blood pressure Blood Pressure - drug effects Blood Pressure - physiology Cardiac output Cardiology Cardiovascular disease Care and treatment Community Diagnosis Double-Blind Method European Continental Ancestry Group Exercise Exercise - physiology Female Fexofenadine Health aspects Heart diseases Heart rate Heart Rate - drug effects Heart Rate - physiology Histamine Histamine H1 Antagonists - pharmacology Histamine H2 Antagonists - pharmacology Histamine receptors Humans Hypertension Hypotension Kidney diseases Kinesiology Leg - blood supply Male Medicine and Health Sciences Mens health Metabolism Nutrition Oxygen Consumption - drug effects Oxygen Consumption - physiology Physical fitness Physical Sciences Physical training Ranitidine Ranitidine - pharmacology Receptors Regional Blood Flow - drug effects Regional Blood Flow - physiology Risk factors Stroke Stroke volume Terfenadine - analogs & derivatives Terfenadine - pharmacology Vascular Resistance - drug effects Vascular Resistance - physiology Vasodilation Womens health Young Adult |
| title | Differential Post-Exercise Blood Pressure Responses between Blacks and Caucasians |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-14T18%3A25%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Differential%20Post-Exercise%20Blood%20Pressure%20Responses%20between%20Blacks%20and%20Caucasians&rft.jtitle=PloS%20one&rft.au=Yan,%20Huimin&rft.date=2016-04-13&rft.volume=11&rft.issue=4&rft.spage=e0153445&rft.epage=e0153445&rft.pages=e0153445-e0153445&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0153445&rft_dat=%3Cgale_plos_%3EA453448293%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1780806339&rft_id=info:pmid/27074034&rft_galeid=A453448293&rft_doaj_id=oai_doaj_org_article_19a060164bd84dc095b2eba73a25dc8d&rfr_iscdi=true |