Bilirubin Binding to PPARα Inhibits Lipid Accumulation

Numerous clinical and population studies have demonstrated that increased serum bilirubin levels protect against cardiovascular and metabolic diseases such as obesity and diabetes. Bilirubin is a potent antioxidant, and the beneficial actions of moderate increases in plasma bilirubin have been thoug...

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Veröffentlicht in:	PloS one 2016-04, Vol.11 (4), p.e0153427-e0153427
Hauptverfasser:	Stec, David E, John, Kezia, Trabbic, Christopher J, Luniwal, Amarjit, Hankins, Michael W, Baum, Justin, Hinds, Jr, Terry D
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Adipocytes Adipose tissue Adiposity - drug effects Animals Antioxidants Bile Bilirubin Bilirubin - metabolism Bilirubin - pharmacology Biliverdin Biology and Life Sciences Biophysics Body composition Body fat Cardiovascular disease Cell Line Diabetes Diabetes mellitus Diet Exercise Fenofibrate Fibroblasts Gene Knockout Techniques Growth factors High fat diet Hypertension Insulin Laboratory animals Ligands Lipid Metabolism - drug effects Liver diseases Male Medicine and Health Sciences Metabolic disorders Metabolic syndrome Mice Models, Molecular NMR Nuclear magnetic resonance Obesity Pharmaceutical sciences Pharmacology Pharmacy Physiology Plasma Population studies PPAR alpha - chemistry PPAR alpha - deficiency PPAR alpha - genetics PPAR alpha - metabolism Precision medicine Protein Binding Protein Conformation Research and analysis methods Rodents Transcription activation Weight control
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