Activation of the PI3K/mTOR Pathway following PARP Inhibition in Small Cell Lung Cancer

Small cell lung cancer (SCLC) is an aggressive malignancy with limited treatment options. We previously found that PARP is overexpressed in SCLC and that targeting PARP reduces cell line and tumor growth in preclinical models. However, SCLC cell lines with PI3K/mTOR pathway activation were relativel...

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Veröffentlicht in:	PloS one 2016-04, Vol.11 (4), p.e0152584-e0152584
Hauptverfasser:	Cardnell, Robert J, Feng, Ying, Mukherjee, Seema, Diao, Lixia, Tong, Pan, Stewart, C Allison, Masrorpour, Fatemeh, Fan, YouHong, Nilsson, Monique, Shen, Yuqiao, Heymach, John V, Wang, Jing, Byers, Lauren A
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Activation AKT protein Aminopyridines - pharmacology AMP-Activated Protein Kinases - antagonists & inhibitors AMP-Activated Protein Kinases - metabolism Analysis Animal models Animals Apoptosis ATP Bioavailability Bioindicators Bioinformatics Biology Biology and Life Sciences Biomarkers Biopsy Biotechnology Breast cancer Cancer Cancer therapies Cell culture Cell Line, Tumor Cellular signal transduction Cellular stress response Chemotherapy Deoxyribonucleic acid Development and progression DNA DNA repair Drugs Female Gene amplification Genetic aspects Humans In vivo methods and tests Indoles - pharmacology Inhibition Inhibitors Kinases LKB1 protein Lung cancer Lung diseases Lung Neoplasms - drug therapy Lung Neoplasms - metabolism Lung Neoplasms - pathology Malignancy Medical research Medicine and Health Sciences Mice Mice, Inbred BALB C Mice, Nude Morpholines - pharmacology Neoplasm Proteins - antagonists & inhibitors Neoplasm Proteins - metabolism Oncology Ovarian cancer Pharmaceutical sciences Phosphatidylinositol 3-Kinases - metabolism Phosphoinositide-3 Kinase Inhibitors Phthalazines - pharmacology Physiological aspects Piperazines - pharmacology Poly (ADP-Ribose) Polymerase-1 Poly(ADP-ribose) polymerase Poly(ADP-ribose) Polymerase Inhibitors - pharmacology Poly(ADP-ribose) Polymerases - metabolism Protein arrays Protein-Serine-Threonine Kinases - antagonists & inhibitors Protein-Serine-Threonine Kinases - metabolism Proteins Research and Analysis Methods Rodents Signal Transduction Signaling Small cell lung cancer Small cell lung carcinoma Small Cell Lung Carcinoma - drug therapy Small Cell Lung Carcinoma - metabolism Small Cell Lung Carcinoma - pathology Studies TOR protein TOR Serine-Threonine Kinases - antagonists & inhibitors TOR Serine-Threonine Kinases - metabolism Tumors Xenograft Model Antitumor Assays
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