Nanoscale Reaction Vessels Designed for Synthesis of Copper-Drug Complexes Suitable for Preclinical Development

The development of copper-drug complexes (CDCs) is hindered due to their very poor aqueous solubility. Diethyldithiocarbamate (DDC) is the primary metabolite of disulfiram, an approved drug for alcoholism that is being repurposed for cancer. The anticancer activity of DDC is dependent on complexatio...

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Veröffentlicht in:	PloS one 2016-04, Vol.11 (4), p.e0153416-e0153416
Hauptverfasser:	Wehbe, Mohamed, Anantha, Malathi, Backstrom, Ian, Leung, Ada, Chen, Kent, Malhotra, Armaan, Edwards, Katarina, Bally, Marcel B
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcoholism Alzheimer's disease Alzheimers disease Animals Anticancer properties Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacology Antineoplastic drugs Antioxidants - chemistry Antioxidants - pharmacology Antitumor activity Antitumor agents Benzothiazoles - chemistry Benzothiazoles - pharmacology Biology and Life Sciences Cancer Cell Survival - drug effects Chemical synthesis Chemotherapy Clioquinol Clioquinol - chemistry Clioquinol - pharmacology Complications and side effects Coordination compounds Copper Copper - chemistry Copper - metabolism Cytotoxicity Disulfiram Ditiocarb - chemistry Ditiocarb - metabolism Dosage and administration Drug abuse Drug delivery systems Drug development Drug therapy Drugs Female Humans Laboratories Liposomes Medical research Medicine and Health Sciences Metabolites Mice Nanotechnology Naphthyridines - chemistry Naphthyridines - pharmacology Neoplasms - drug therapy Neoplasms - pathology Pharmaceutical sciences Physical Sciences Quercetin Quercetin - chemistry Quercetin - pharmacology R&D Research & development Solubility Tumor Cells, Cultured Xenograft Model Antitumor Assays
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