Spatio-Temporal Patterns of Demyelination and Remyelination in the Cuprizone Mouse Model

Cuprizone administration in mice provides a reproducible model of demyelination and spontaneous remyelination, and has been useful in understanding important aspects of human disease, including multiple sclerosis. In this study, we apply high spatial resolution quantitative MRI techniques to establi...

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Veröffentlicht in:	PloS one 2016-04, Vol.11 (4), p.e0152480
Hauptverfasser:	Tagge, Ian, O'Connor, Audrey, Chaudhary, Priya, Pollaro, Jim, Berlow, Yosef, Chalupsky, Megan, Bourdette, Dennis, Woltjer, Randy, Johnson, Mac, Rooney, William
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescents Animals Apoptosis Biology and Life Sciences Biomedical engineering Body Weight - drug effects Brain Brain - drug effects Brain - metabolism Brain - pathology Brain damage Brain mapping Brain research Corpus callosum Corpus Callosum - drug effects Corpus Callosum - pathology Cuprizone Cuprizone - toxicity Demyelinating diseases Demyelinating Diseases - chemically induced Demyelination Development and progression Disease Models, Animal Gene expression Gene mapping Genetic aspects Gold House mouse Image Processing, Computer-Assisted Internet Magnetic Resonance Imaging Male Medicine and Health Sciences Mice Mice, Inbred C57BL Multiple sclerosis Myelin Myelin basic protein Myelin proteins Myelin Sheath - metabolism Myelination Neurology NMR Nuclear magnetic resonance Pathology Physiological aspects Progenitor cells Recovery Repair Research and Analysis Methods Reunions Rodents Science Spatial discrimination Spatial resolution Stem cells Substantia alba Transcriptome
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