Comparison of Gender Differences in Intracerebral Hemorrhage in a Multi-Ethnic Asian Population
Intracerebral hemorrhage (ICH) accounts for 10-15% of all first time strokes and with incidence twice as high in the Asian compared to Western population. This study aims to investigate gender differences in ICH patient outcomes in a multi-ethnic Asian population. Data for 1,192 patients admitted fo...
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| description | Intracerebral hemorrhage (ICH) accounts for 10-15% of all first time strokes and with incidence twice as high in the Asian compared to Western population. This study aims to investigate gender differences in ICH patient outcomes in a multi-ethnic Asian population.
Data for 1,192 patients admitted for ICH were collected over a four-year period. Multivariate logistic regression was used to identify independent predictors and odds ratios were computed for 30-day mortality and Glasgow Outcome Scale (GOS) comparing males and females.
Males suffered ICH at a younger age than females (62.2 ± 13.2 years vs. 66.3 ± 15.3 years; P |
| doi_str_mv | 10.1371/journal.pone.0152945 |
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Data for 1,192 patients admitted for ICH were collected over a four-year period. Multivariate logistic regression was used to identify independent predictors and odds ratios were computed for 30-day mortality and Glasgow Outcome Scale (GOS) comparing males and females.
Males suffered ICH at a younger age than females (62.2 ± 13.2 years vs. 66.3 ± 15.3 years; P<0.001). The occurrence of ICH was higher among males than females at all ages until 80 years old, beyond which the trend was reversed. Females exhibited increased severity on admission as measured by Glasgow Coma Scale compared to males (10.9 ± 4.03 vs. 11.4 ± 4.04; P = 0.030). No difference was found in 30-day mortality between females and males (F: 30.5% [155/508] vs. M: 27.0% [186/688]), with unadjusted and adjusted odds ratio (F/M) of 1.19 (P = 0.188) and 1.21 (P = 0.300). At discharge, there was a non-statistically significant but potentially clinically relevant morbidity difference between the genders as measured by GOS (dichotomized GOS of 4-5: F: 23.7% [119/503] vs. M: 28.7% [194/677]), with unadjusted and adjusted odds ratio (F/M) of 0.77 (P = 0.055) and 0.87 (P = 0.434).
In our multi-ethnic Asian population, males developed ICH at a younger age and were more susceptible to ICH than women at all ages other than the beyond 80-year old age group. In contrast to the Western population, neurological status of female ICH patients at admission was poorer and their 30-day mortality was not reduced. Although the study was not powered to detect significance, female showed a trend toward worse 30-day morbidity at discharge.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0152945</identifier><identifier>PMID: 27050549</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Age ; Aged ; Aged, 80 and over ; Analysis ; Asian Continental Ancestry Group ; Biology and Life Sciences ; Blood pressure ; Brain research ; Cardiovascular disease ; Care and treatment ; Cerebral Hemorrhage - epidemiology ; Cerebral Hemorrhage - ethnology ; Coma ; Demographics ; Diabetic neuropathy ; Discharge ; Epidemiology ; Ethnic Groups ; Ethnicity ; Family medical history ; Female ; Females ; Gender aspects ; Gender differences ; Heart ; Hemorrhage ; Humans ; Hydrocephalus ; Intracerebral hemorrhage ; Ischemia ; Male ; Males ; Medicine and Health Sciences ; Middle Aged ; Morbidity ; Mortality ; Neurosciences ; Neurosurgery ; Patient outcomes ; Patients ; People and Places ; Population ; Population studies ; Risk factors ; Sex differences ; Sex differences (Biology) ; Sex Factors ; Statistical analysis ; Stroke ; Studies</subject><ispartof>PloS one, 2016-04, Vol.11 (4), p.e0152945-e0152945</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Hsieh et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2016 Hsieh et al 2016 Hsieh et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c758t-62a83d9a0277d5c01c9cf19c8c26608c1277c42be97d029d33c4298c3015db3f3</citedby><cites>FETCH-LOGICAL-c758t-62a83d9a0277d5c01c9cf19c8c26608c1277c42be97d029d33c4298c3015db3f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822850/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822850/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27050549$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hsieh, Justin T</creatorcontrib><creatorcontrib>Ang, Beng Ti</creatorcontrib><creatorcontrib>Ng, Yew Poh</creatorcontrib><creatorcontrib>Allen, John C</creatorcontrib><creatorcontrib>King, Nicolas K K</creatorcontrib><title>Comparison of Gender Differences in Intracerebral Hemorrhage in a Multi-Ethnic Asian Population</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Intracerebral hemorrhage (ICH) accounts for 10-15% of all first time strokes and with incidence twice as high in the Asian compared to Western population. This study aims to investigate gender differences in ICH patient outcomes in a multi-ethnic Asian population.
Data for 1,192 patients admitted for ICH were collected over a four-year period. Multivariate logistic regression was used to identify independent predictors and odds ratios were computed for 30-day mortality and Glasgow Outcome Scale (GOS) comparing males and females.
Males suffered ICH at a younger age than females (62.2 ± 13.2 years vs. 66.3 ± 15.3 years; P<0.001). The occurrence of ICH was higher among males than females at all ages until 80 years old, beyond which the trend was reversed. Females exhibited increased severity on admission as measured by Glasgow Coma Scale compared to males (10.9 ± 4.03 vs. 11.4 ± 4.04; P = 0.030). No difference was found in 30-day mortality between females and males (F: 30.5% [155/508] vs. M: 27.0% [186/688]), with unadjusted and adjusted odds ratio (F/M) of 1.19 (P = 0.188) and 1.21 (P = 0.300). At discharge, there was a non-statistically significant but potentially clinically relevant morbidity difference between the genders as measured by GOS (dichotomized GOS of 4-5: F: 23.7% [119/503] vs. M: 28.7% [194/677]), with unadjusted and adjusted odds ratio (F/M) of 0.77 (P = 0.055) and 0.87 (P = 0.434).
In our multi-ethnic Asian population, males developed ICH at a younger age and were more susceptible to ICH than women at all ages other than the beyond 80-year old age group. In contrast to the Western population, neurological status of female ICH patients at admission was poorer and their 30-day mortality was not reduced. Although the study was not powered to detect significance, female showed a trend toward worse 30-day morbidity at discharge.</description><subject>Age</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Analysis</subject><subject>Asian Continental Ancestry Group</subject><subject>Biology and Life Sciences</subject><subject>Blood pressure</subject><subject>Brain research</subject><subject>Cardiovascular disease</subject><subject>Care and treatment</subject><subject>Cerebral Hemorrhage - epidemiology</subject><subject>Cerebral Hemorrhage - ethnology</subject><subject>Coma</subject><subject>Demographics</subject><subject>Diabetic neuropathy</subject><subject>Discharge</subject><subject>Epidemiology</subject><subject>Ethnic Groups</subject><subject>Ethnicity</subject><subject>Family medical history</subject><subject>Female</subject><subject>Females</subject><subject>Gender aspects</subject><subject>Gender differences</subject><subject>Heart</subject><subject>Hemorrhage</subject><subject>Humans</subject><subject>Hydrocephalus</subject><subject>Intracerebral hemorrhage</subject><subject>Ischemia</subject><subject>Male</subject><subject>Males</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Morbidity</subject><subject>Mortality</subject><subject>Neurosciences</subject><subject>Neurosurgery</subject><subject>Patient outcomes</subject><subject>Patients</subject><subject>People and Places</subject><subject>Population</subject><subject>Population studies</subject><subject>Risk factors</subject><subject>Sex differences</subject><subject>Sex differences (Biology)</subject><subject>Sex Factors</subject><subject>Statistical analysis</subject><subject>Stroke</subject><subject>Studies</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk01vEzEQhlcIREvhHyBYCQnBIcGfu_YFKQqljVRUxNfVcmxv4shrp_Yugn-Pl2yrLOoB-WB7_Mxrz3imKJ5DMIe4hu92oY9euvk-eDMHkCJO6IPiFHKMZhUC-OHR-qR4ktIOAIpZVT0uTlANKKCEnxZiGdq9jDYFX4amvDBem1h-sE1jovHKpNL6cuW7KFU2rKN05aVpQ4xbuTHDmSw_9a6zs_Nu660qF8lKX34O-97Jzgb_tHjUSJfMs3E-K75_PP-2vJxdXV-slourmaop6_IjJcOaS4DqWlMFoOKqgVwxhaoKMAWzXRG0NrzWAHGNcd5xpnAOXK9xg8-KlwfdvQtJjLlJAtY1BxhzVGVidSB0kDuxj7aV8bcI0oq_hhA3QsbOKmdEg6WilQISMUCIhoxgSiRRQFcMVURnrffjbf26NVqZIUFuIjo98XYrNuGnIAwhRkEWeDMKxHDTm9SJ1iZlnJPehP7wbsYIwCijr_5B749upDYyB2B9E4YvG0TFglBMKAKUZmp-D5WHNq1VuZAam-0Th7cTh8x05le3kX1KYvX1y_-z1z-m7Osjdmuk67YpuH4omTQFyQFUMaQUTXOXZAjE0Ae32RBDH4ixD7Lbi-MPunO6LXz8B0LPAP8</recordid><startdate>20160406</startdate><enddate>20160406</enddate><creator>Hsieh, Justin T</creator><creator>Ang, Beng Ti</creator><creator>Ng, Yew Poh</creator><creator>Allen, John C</creator><creator>King, Nicolas K K</creator><general>Public Library of Science</general><general>Public Library of Science 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of Gender Differences in Intracerebral Hemorrhage in a Multi-Ethnic Asian Population</title><author>Hsieh, Justin T ; Ang, Beng Ti ; Ng, Yew Poh ; Allen, John C ; King, Nicolas K K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c758t-62a83d9a0277d5c01c9cf19c8c26608c1277c42be97d029d33c4298c3015db3f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Age</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Analysis</topic><topic>Asian Continental Ancestry Group</topic><topic>Biology and Life Sciences</topic><topic>Blood pressure</topic><topic>Brain research</topic><topic>Cardiovascular disease</topic><topic>Care and treatment</topic><topic>Cerebral Hemorrhage - epidemiology</topic><topic>Cerebral Hemorrhage - ethnology</topic><topic>Coma</topic><topic>Demographics</topic><topic>Diabetic 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analysis</topic><topic>Stroke</topic><topic>Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hsieh, Justin T</creatorcontrib><creatorcontrib>Ang, Beng Ti</creatorcontrib><creatorcontrib>Ng, Yew Poh</creatorcontrib><creatorcontrib>Allen, John C</creatorcontrib><creatorcontrib>King, Nicolas K K</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Opposing Viewpoints in Context (Gale)</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Proquest Nursing & Allied Health 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Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hsieh, Justin T</au><au>Ang, Beng Ti</au><au>Ng, Yew Poh</au><au>Allen, John C</au><au>King, Nicolas K K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of Gender Differences in Intracerebral Hemorrhage in a Multi-Ethnic Asian Population</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2016-04-06</date><risdate>2016</risdate><volume>11</volume><issue>4</issue><spage>e0152945</spage><epage>e0152945</epage><pages>e0152945-e0152945</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Intracerebral hemorrhage (ICH) accounts for 10-15% of all first time strokes and with incidence twice as high in the Asian compared to Western population. This study aims to investigate gender differences in ICH patient outcomes in a multi-ethnic Asian population.
Data for 1,192 patients admitted for ICH were collected over a four-year period. Multivariate logistic regression was used to identify independent predictors and odds ratios were computed for 30-day mortality and Glasgow Outcome Scale (GOS) comparing males and females.
Males suffered ICH at a younger age than females (62.2 ± 13.2 years vs. 66.3 ± 15.3 years; P<0.001). The occurrence of ICH was higher among males than females at all ages until 80 years old, beyond which the trend was reversed. Females exhibited increased severity on admission as measured by Glasgow Coma Scale compared to males (10.9 ± 4.03 vs. 11.4 ± 4.04; P = 0.030). No difference was found in 30-day mortality between females and males (F: 30.5% [155/508] vs. M: 27.0% [186/688]), with unadjusted and adjusted odds ratio (F/M) of 1.19 (P = 0.188) and 1.21 (P = 0.300). At discharge, there was a non-statistically significant but potentially clinically relevant morbidity difference between the genders as measured by GOS (dichotomized GOS of 4-5: F: 23.7% [119/503] vs. M: 28.7% [194/677]), with unadjusted and adjusted odds ratio (F/M) of 0.77 (P = 0.055) and 0.87 (P = 0.434).
In our multi-ethnic Asian population, males developed ICH at a younger age and were more susceptible to ICH than women at all ages other than the beyond 80-year old age group. In contrast to the Western population, neurological status of female ICH patients at admission was poorer and their 30-day mortality was not reduced. Although the study was not powered to detect significance, female showed a trend toward worse 30-day morbidity at discharge.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>27050549</pmid><doi>10.1371/journal.pone.0152945</doi><oa>free_for_read</oa></addata></record> |
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| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Age Aged Aged, 80 and over Analysis Asian Continental Ancestry Group Biology and Life Sciences Blood pressure Brain research Cardiovascular disease Care and treatment Cerebral Hemorrhage - epidemiology Cerebral Hemorrhage - ethnology Coma Demographics Diabetic neuropathy Discharge Epidemiology Ethnic Groups Ethnicity Family medical history Female Females Gender aspects Gender differences Heart Hemorrhage Humans Hydrocephalus Intracerebral hemorrhage Ischemia Male Males Medicine and Health Sciences Middle Aged Morbidity Mortality Neurosciences Neurosurgery Patient outcomes Patients People and Places Population Population studies Risk factors Sex differences Sex differences (Biology) Sex Factors Statistical analysis Stroke Studies |
| title | Comparison of Gender Differences in Intracerebral Hemorrhage in a Multi-Ethnic Asian Population |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T13%3A03%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Comparison%20of%20Gender%20Differences%20in%20Intracerebral%20Hemorrhage%20in%20a%20Multi-Ethnic%20Asian%20Population&rft.jtitle=PloS%20one&rft.au=Hsieh,%20Justin%20T&rft.date=2016-04-06&rft.volume=11&rft.issue=4&rft.spage=e0152945&rft.epage=e0152945&rft.pages=e0152945-e0152945&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0152945&rft_dat=%3Cgale_plos_%3EA453452055%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1779033926&rft_id=info:pmid/27050549&rft_galeid=A453452055&rft_doaj_id=oai_doaj_org_article_f3ac56c0a28044d184354a4c0d68264d&rfr_iscdi=true |