Smoking and Subclinical ILD in RA versus the Multi-Ethnic Study of Atherosclerosis
A population-based cohort showed an association between cigarette smoking and subclinical parenchymal lung disease defined as regions of increased computed tomography (CT) lung densitometry. This technique has not been applied to the rheumatoid arthritis (RA) population where associated ILD is highl...
Gespeichert in:
| Veröffentlicht in: | PloS one 2016-04, Vol.11 (4), p.e0153024-e0153024 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e0153024 |
|---|---|
| container_issue | 4 |
| container_start_page | e0153024 |
| container_title | PloS one |
| container_volume | 11 |
| creator | Johnson, Cheilonda Giles, Jon T Bathon, Joan Lederer, David Hoffman, Eric A Barr, R Graham Danoff, Sonye K |
| description | A population-based cohort showed an association between cigarette smoking and subclinical parenchymal lung disease defined as regions of increased computed tomography (CT) lung densitometry. This technique has not been applied to the rheumatoid arthritis (RA) population where associated ILD is highly prevalent. The association between cumulative cigarette smoking and volume of areas of high attenuation (HAA: >-600 and |
| doi_str_mv | 10.1371/journal.pone.0153024 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1779033710</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A453452025</galeid><doaj_id>oai_doaj_org_article_82d11941b466414487a58f0dee0ceea8</doaj_id><sourcerecordid>A453452025</sourcerecordid><originalsourceid>FETCH-LOGICAL-c692t-5081ed00eb81004f43a2b4fd2004e4168557db225ab60a820141fbf8d8569f173</originalsourceid><addsrcrecordid>eNqNkl2LEzEUhgdR3HX1H4gGBNGL1nzOpDdC2V21UFlo1duQmSRtapp0J5ll99-b2tmlI3shgXw-5z3JyVsUrxEcI1KhT5vQtV668S54PYaIEYjpk-IUTQgelRiSp0fzk-JFjBsIGeFl-bw4wRVkkBJyWiyW2_Db-hWQXoFlVzfOettIB2bzC2A9WEzBjW5jF0Faa_C9c8mOLtM6M2CZOnUHggHTfNSG2Lh9b-PL4pmRLupX_XhW_Pxy-eP822h-9XV2Pp2PmnKC04hBjrSCUNccQUgNJRLX1CicF5qikjNWqRpjJusSSo4hosjUhivOyolBFTkr3h50dy5E0ZcjClRVE0hyhWAmZgdCBbkRu9ZuZXsngrTi70ZoV0K2yeaLC44VQhOKalqWFFHKK8m4gUpr2Ggtedb63Gfr6q1WjfaplW4gOjzxdi1W4UZQjnFVlVngQy_QhutOxyS2NjbaOel16A735hwTjDP67h_08df11ErmB1hvQs7b7EXFlDJCGYaYZWr8CJWb0lvbZO8Ym_cHAR8HAZlJ-jatZBejmC0X_89e_Rqy74_YtZYurWNwXbLBxyFID2CT7RRbbR6KjKDYW_--GmJvfdFbP4e9Of6gh6B7r5M_G2T7UQ</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1779033710</pqid></control><display><type>article</type><title>Smoking and Subclinical ILD in RA versus the Multi-Ethnic Study of Atherosclerosis</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><source>Public Library of Science (PLoS)</source><creator>Johnson, Cheilonda ; Giles, Jon T ; Bathon, Joan ; Lederer, David ; Hoffman, Eric A ; Barr, R Graham ; Danoff, Sonye K</creator><creatorcontrib>Johnson, Cheilonda ; Giles, Jon T ; Bathon, Joan ; Lederer, David ; Hoffman, Eric A ; Barr, R Graham ; Danoff, Sonye K</creatorcontrib><description>A population-based cohort showed an association between cigarette smoking and subclinical parenchymal lung disease defined as regions of increased computed tomography (CT) lung densitometry. This technique has not been applied to the rheumatoid arthritis (RA) population where associated ILD is highly prevalent. The association between cumulative cigarette smoking and volume of areas of high attenuation (HAA: >-600 and <-250 Hounsfield Units) on full inspiratory CT was compared in 172 RA participants and 3,969 controls in a general population sample. Multivariable regression models were used to adjust for demography, anthropometrics, percent emphysema, and CT parameters. The mean cumulative cigarette smoking exposure was 25 (IQR 10-42) and 15(IQR 5-31) pack-years for the RA and non-RA cohorts, respectively. Mean HAA was 153(±57) cm3 and 129(±50) cm3 in the RA and non-RA cohorts, respectively. Each 10 cigarette pack-year increment was associated with a higher HAA by 0.03% (95% CI, 0.007-0.05%) in RA patients and by 0.008% (95% CI, 0.003-0.01%) in those without RA (interaction p = 0.001). Cigarette smoking was associated with higher lung attenuation; with a magnitude of association more pronounced in those with RA than in the general population. These data suggest that cigarette smoking may be a more potent ILD risk factor for RA patients than in the general population.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0153024</identifier><identifier>PMID: 27050433</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Aged ; Arteriosclerosis ; Arthritis ; Atherosclerosis ; Atherosclerosis - complications ; Atherosclerosis - ethnology ; Attenuation ; Biology and Life Sciences ; Body measurements ; Cardiovascular disease ; Chronic obstructive pulmonary disease ; Cigarette smoking ; Computed tomography ; Coronary vessels ; Critical care ; Demography ; Densitometers ; Densitometry ; Diseases ; Emphysema ; Female ; Health risk assessment ; Humans ; Inflammation ; Lung diseases ; Lung Diseases, Interstitial - complications ; Lung Diseases, Interstitial - diagnostic imaging ; Lung Diseases, Interstitial - etiology ; Male ; Medicine ; Medicine and Health Sciences ; Middle Aged ; Multivariable control ; Patients ; Physiology ; Population studies ; Regression analysis ; Regression models ; Research and Analysis Methods ; Respiration ; Rheumatism ; Rheumatoid arthritis ; Rheumatology ; Risk factors ; Smoking ; Smoking - adverse effects ; Social Sciences ; Surgeons ; Tomography ; Tomography, X-Ray Computed</subject><ispartof>PloS one, 2016-04, Vol.11 (4), p.e0153024-e0153024</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Johnson et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2016 Johnson et al 2016 Johnson et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-5081ed00eb81004f43a2b4fd2004e4168557db225ab60a820141fbf8d8569f173</citedby><cites>FETCH-LOGICAL-c692t-5081ed00eb81004f43a2b4fd2004e4168557db225ab60a820141fbf8d8569f173</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822776/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822776/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27050433$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Johnson, Cheilonda</creatorcontrib><creatorcontrib>Giles, Jon T</creatorcontrib><creatorcontrib>Bathon, Joan</creatorcontrib><creatorcontrib>Lederer, David</creatorcontrib><creatorcontrib>Hoffman, Eric A</creatorcontrib><creatorcontrib>Barr, R Graham</creatorcontrib><creatorcontrib>Danoff, Sonye K</creatorcontrib><title>Smoking and Subclinical ILD in RA versus the Multi-Ethnic Study of Atherosclerosis</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>A population-based cohort showed an association between cigarette smoking and subclinical parenchymal lung disease defined as regions of increased computed tomography (CT) lung densitometry. This technique has not been applied to the rheumatoid arthritis (RA) population where associated ILD is highly prevalent. The association between cumulative cigarette smoking and volume of areas of high attenuation (HAA: >-600 and <-250 Hounsfield Units) on full inspiratory CT was compared in 172 RA participants and 3,969 controls in a general population sample. Multivariable regression models were used to adjust for demography, anthropometrics, percent emphysema, and CT parameters. The mean cumulative cigarette smoking exposure was 25 (IQR 10-42) and 15(IQR 5-31) pack-years for the RA and non-RA cohorts, respectively. Mean HAA was 153(±57) cm3 and 129(±50) cm3 in the RA and non-RA cohorts, respectively. Each 10 cigarette pack-year increment was associated with a higher HAA by 0.03% (95% CI, 0.007-0.05%) in RA patients and by 0.008% (95% CI, 0.003-0.01%) in those without RA (interaction p = 0.001). Cigarette smoking was associated with higher lung attenuation; with a magnitude of association more pronounced in those with RA than in the general population. These data suggest that cigarette smoking may be a more potent ILD risk factor for RA patients than in the general population.</description><subject>Aged</subject><subject>Arteriosclerosis</subject><subject>Arthritis</subject><subject>Atherosclerosis</subject><subject>Atherosclerosis - complications</subject><subject>Atherosclerosis - ethnology</subject><subject>Attenuation</subject><subject>Biology and Life Sciences</subject><subject>Body measurements</subject><subject>Cardiovascular disease</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Cigarette smoking</subject><subject>Computed tomography</subject><subject>Coronary vessels</subject><subject>Critical care</subject><subject>Demography</subject><subject>Densitometers</subject><subject>Densitometry</subject><subject>Diseases</subject><subject>Emphysema</subject><subject>Female</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Lung diseases</subject><subject>Lung Diseases, Interstitial - complications</subject><subject>Lung Diseases, Interstitial - diagnostic imaging</subject><subject>Lung Diseases, Interstitial - etiology</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Multivariable control</subject><subject>Patients</subject><subject>Physiology</subject><subject>Population studies</subject><subject>Regression analysis</subject><subject>Regression models</subject><subject>Research and Analysis Methods</subject><subject>Respiration</subject><subject>Rheumatism</subject><subject>Rheumatoid arthritis</subject><subject>Rheumatology</subject><subject>Risk factors</subject><subject>Smoking</subject><subject>Smoking - adverse effects</subject><subject>Social Sciences</subject><subject>Surgeons</subject><subject>Tomography</subject><subject>Tomography, X-Ray Computed</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl2LEzEUhgdR3HX1H4gGBNGL1nzOpDdC2V21UFlo1duQmSRtapp0J5ll99-b2tmlI3shgXw-5z3JyVsUrxEcI1KhT5vQtV668S54PYaIEYjpk-IUTQgelRiSp0fzk-JFjBsIGeFl-bw4wRVkkBJyWiyW2_Db-hWQXoFlVzfOettIB2bzC2A9WEzBjW5jF0Faa_C9c8mOLtM6M2CZOnUHggHTfNSG2Lh9b-PL4pmRLupX_XhW_Pxy-eP822h-9XV2Pp2PmnKC04hBjrSCUNccQUgNJRLX1CicF5qikjNWqRpjJusSSo4hosjUhivOyolBFTkr3h50dy5E0ZcjClRVE0hyhWAmZgdCBbkRu9ZuZXsngrTi70ZoV0K2yeaLC44VQhOKalqWFFHKK8m4gUpr2Ggtedb63Gfr6q1WjfaplW4gOjzxdi1W4UZQjnFVlVngQy_QhutOxyS2NjbaOel16A735hwTjDP67h_08df11ErmB1hvQs7b7EXFlDJCGYaYZWr8CJWb0lvbZO8Ym_cHAR8HAZlJ-jatZBejmC0X_89e_Rqy74_YtZYurWNwXbLBxyFID2CT7RRbbR6KjKDYW_--GmJvfdFbP4e9Of6gh6B7r5M_G2T7UQ</recordid><startdate>20160406</startdate><enddate>20160406</enddate><creator>Johnson, Cheilonda</creator><creator>Giles, Jon T</creator><creator>Bathon, Joan</creator><creator>Lederer, David</creator><creator>Hoffman, Eric A</creator><creator>Barr, R Graham</creator><creator>Danoff, Sonye K</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20160406</creationdate><title>Smoking and Subclinical ILD in RA versus the Multi-Ethnic Study of Atherosclerosis</title><author>Johnson, Cheilonda ; Giles, Jon T ; Bathon, Joan ; Lederer, David ; Hoffman, Eric A ; Barr, R Graham ; Danoff, Sonye K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-5081ed00eb81004f43a2b4fd2004e4168557db225ab60a820141fbf8d8569f173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged</topic><topic>Arteriosclerosis</topic><topic>Arthritis</topic><topic>Atherosclerosis</topic><topic>Atherosclerosis - complications</topic><topic>Atherosclerosis - ethnology</topic><topic>Attenuation</topic><topic>Biology and Life Sciences</topic><topic>Body measurements</topic><topic>Cardiovascular disease</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Cigarette smoking</topic><topic>Computed tomography</topic><topic>Coronary vessels</topic><topic>Critical care</topic><topic>Demography</topic><topic>Densitometers</topic><topic>Densitometry</topic><topic>Diseases</topic><topic>Emphysema</topic><topic>Female</topic><topic>Health risk assessment</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Lung diseases</topic><topic>Lung Diseases, Interstitial - complications</topic><topic>Lung Diseases, Interstitial - diagnostic imaging</topic><topic>Lung Diseases, Interstitial - etiology</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine and Health Sciences</topic><topic>Middle Aged</topic><topic>Multivariable control</topic><topic>Patients</topic><topic>Physiology</topic><topic>Population studies</topic><topic>Regression analysis</topic><topic>Regression models</topic><topic>Research and Analysis Methods</topic><topic>Respiration</topic><topic>Rheumatism</topic><topic>Rheumatoid arthritis</topic><topic>Rheumatology</topic><topic>Risk factors</topic><topic>Smoking</topic><topic>Smoking - adverse effects</topic><topic>Social Sciences</topic><topic>Surgeons</topic><topic>Tomography</topic><topic>Tomography, X-Ray Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Johnson, Cheilonda</creatorcontrib><creatorcontrib>Giles, Jon T</creatorcontrib><creatorcontrib>Bathon, Joan</creatorcontrib><creatorcontrib>Lederer, David</creatorcontrib><creatorcontrib>Hoffman, Eric A</creatorcontrib><creatorcontrib>Barr, R Graham</creatorcontrib><creatorcontrib>Danoff, Sonye K</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Johnson, Cheilonda</au><au>Giles, Jon T</au><au>Bathon, Joan</au><au>Lederer, David</au><au>Hoffman, Eric A</au><au>Barr, R Graham</au><au>Danoff, Sonye K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Smoking and Subclinical ILD in RA versus the Multi-Ethnic Study of Atherosclerosis</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2016-04-06</date><risdate>2016</risdate><volume>11</volume><issue>4</issue><spage>e0153024</spage><epage>e0153024</epage><pages>e0153024-e0153024</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>A population-based cohort showed an association between cigarette smoking and subclinical parenchymal lung disease defined as regions of increased computed tomography (CT) lung densitometry. This technique has not been applied to the rheumatoid arthritis (RA) population where associated ILD is highly prevalent. The association between cumulative cigarette smoking and volume of areas of high attenuation (HAA: >-600 and <-250 Hounsfield Units) on full inspiratory CT was compared in 172 RA participants and 3,969 controls in a general population sample. Multivariable regression models were used to adjust for demography, anthropometrics, percent emphysema, and CT parameters. The mean cumulative cigarette smoking exposure was 25 (IQR 10-42) and 15(IQR 5-31) pack-years for the RA and non-RA cohorts, respectively. Mean HAA was 153(±57) cm3 and 129(±50) cm3 in the RA and non-RA cohorts, respectively. Each 10 cigarette pack-year increment was associated with a higher HAA by 0.03% (95% CI, 0.007-0.05%) in RA patients and by 0.008% (95% CI, 0.003-0.01%) in those without RA (interaction p = 0.001). Cigarette smoking was associated with higher lung attenuation; with a magnitude of association more pronounced in those with RA than in the general population. These data suggest that cigarette smoking may be a more potent ILD risk factor for RA patients than in the general population.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>27050433</pmid><doi>10.1371/journal.pone.0153024</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2016-04, Vol.11 (4), p.e0153024-e0153024 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1779033710 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Aged Arteriosclerosis Arthritis Atherosclerosis Atherosclerosis - complications Atherosclerosis - ethnology Attenuation Biology and Life Sciences Body measurements Cardiovascular disease Chronic obstructive pulmonary disease Cigarette smoking Computed tomography Coronary vessels Critical care Demography Densitometers Densitometry Diseases Emphysema Female Health risk assessment Humans Inflammation Lung diseases Lung Diseases, Interstitial - complications Lung Diseases, Interstitial - diagnostic imaging Lung Diseases, Interstitial - etiology Male Medicine Medicine and Health Sciences Middle Aged Multivariable control Patients Physiology Population studies Regression analysis Regression models Research and Analysis Methods Respiration Rheumatism Rheumatoid arthritis Rheumatology Risk factors Smoking Smoking - adverse effects Social Sciences Surgeons Tomography Tomography, X-Ray Computed |
| title | Smoking and Subclinical ILD in RA versus the Multi-Ethnic Study of Atherosclerosis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T08%3A43%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Smoking%20and%20Subclinical%20ILD%20in%20RA%20versus%20the%20Multi-Ethnic%20Study%20of%20Atherosclerosis&rft.jtitle=PloS%20one&rft.au=Johnson,%20Cheilonda&rft.date=2016-04-06&rft.volume=11&rft.issue=4&rft.spage=e0153024&rft.epage=e0153024&rft.pages=e0153024-e0153024&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0153024&rft_dat=%3Cgale_plos_%3EA453452025%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1779033710&rft_id=info:pmid/27050433&rft_galeid=A453452025&rft_doaj_id=oai_doaj_org_article_82d11941b466414487a58f0dee0ceea8&rfr_iscdi=true |