PKR Transduces MDA5-Dependent Signals for Type I IFN Induction

Sensing invading pathogens early in infection is critical for establishing host defense. Two cytosolic RIG-like RNA helicases, RIG-I and MDA5, are key to type I interferon (IFN) induction in response to viral infection. Mounting evidence suggests that another viral RNA sensor, protein kinase R (PKR)...

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Veröffentlicht in:	PLoS pathogens 2016-03, Vol.12 (3), p.e1005489-e1005489
Hauptverfasser:	Pham, Alissa M, Santa Maria, Felicia Gilfoy, Lahiri, Tanaya, Friedman, Eugene, Marié, Isabelle J, Levy, David E
Format:	Artikel
Sprache:	eng
Schlagworte:	Biology and Life Sciences Cell Line Cellular signal transduction DEAD Box Protein 58 DEAD-box RNA Helicases - genetics DEAD-box RNA Helicases - metabolism eIF-2 Kinase - genetics eIF-2 Kinase - metabolism Encephalomyocarditis virus - genetics Encephalomyocarditis virus - immunology Eukaryotic Initiation Factor-2 - genetics Eukaryotic Initiation Factor-2 - metabolism Genes, Reporter Genetic aspects Glycerol Health aspects Humans Immune response Infections Interferon Interferon Type I - metabolism Interferon-Induced Helicase, IFIH1 Kinases Laboratories Medicine and Health Sciences Mutation Phosphorylation Protein expression Protein kinases Proteins Receptors, Immunologic Research and Analysis Methods RNA, Viral - genetics Signal Transduction Vaccinia - immunology Vaccinia - virology Vaccinia virus - genetics Vaccinia virus - immunology Viral infections Viral Proteins - genetics Viral Proteins - metabolism Viruses
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