Molecular Determinants of GS-9620-Dependent TLR7 Activation

GS-9620 is an orally administered agonist of Toll-like receptor (TLR)7 currently being evaluated in clinical studies for the treatment of chronic HBV and HIV patients. GS-9620 has shown antiviral efficacy in preclinical models of chronic hepadnavirus infection in woodchuck as well as chimpanzee. How...

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Veröffentlicht in:	PloS one 2016-01, Vol.11 (1), p.e0146835-e0146835
Hauptverfasser:	Rebbapragada, Indrani, Birkus, Gabriel, Perry, Jason, Xing, Weimei, Kwon, HyockJoo, Pflanz, Stefan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine triphosphatase AKT protein Amino Acid Sequence Binding Sites Biology Cell activation Cells, Cultured Chronic infection Dendritic cells Deoxyribonucleic acid Determinants DNA Drug resistance Drug therapy Genetic aspects HEK293 Cells Hepatitis Hepatitis B HIV infections Humans Immune system Immunoglobulins Immunology Ligands Molecular interactions Molecular Sequence Data Molecular structure Mutation NF-κB protein Oral administration Penicillin Physiological aspects Polymorphism, Single Nucleotide Protein Binding Proteins Pteridines - pharmacology Signal transduction Single-nucleotide polymorphism TLR7 protein Toll-Like Receptor 7 - agonists Toll-Like Receptor 7 - chemistry Toll-Like Receptor 7 - genetics Toll-Like Receptor 7 - metabolism Toll-like receptors
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