Perioperative Use of Clevidipine: A Systematic Review and Meta-Analysis
Clevidipine is an ultrashort-acting drug for rapid reduction of blood pressure by selectively acting on the L-type Ca2+ channels on arteriolar smooth muscle. The drug's ultrashort action in reducing the blood pressure is due to its rapid hydrolysis by blood and extravascular tissue esterases, w...
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| creator | Espinosa, Angel Ripollés-Melchor, Javier Casans-Francés, Rubén Abad-Gurumeta, Alfredo Bergese, Sergio D Zuleta-Alarcon, Alix López-Timoneda, Francisco Calvo-Vecino, José María |
| description | Clevidipine is an ultrashort-acting drug for rapid reduction of blood pressure by selectively acting on the L-type Ca2+ channels on arteriolar smooth muscle. The drug's ultrashort action in reducing the blood pressure is due to its rapid hydrolysis by blood and extravascular tissue esterases, which does not depend on hepato-renal metabolism and excretion. An analysis of the perioperative management of blood pressure should be considered to compare with other intravenous antihypertensive agents.
Analyses of the available evidence in randomized clinical trials following the PRISMA methodology as well as clinical significance according to the GRADE system were conducted. Placebo versus other antihypertensive drugs studies were included. Statistical assessments were done using the X2 and I2 tests.
Clevidipine was more effective in maintaining the blood pressure within pre-specified ranges compared with other antihypertensive drugs (MD, -17.87 CI 95%: -29.02 to -6.72; p = 0.02). The use of Clevidipine versus placebo and rescue antihypertensive intravenous drug showed a clear reduction in rates of treatment failure (RR 0.10; IC 95%; 0.05-0.18; p |
| doi_str_mv | 10.1371/journal.pone.0150625 |
| format | Article |
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Analyses of the available evidence in randomized clinical trials following the PRISMA methodology as well as clinical significance according to the GRADE system were conducted. Placebo versus other antihypertensive drugs studies were included. Statistical assessments were done using the X2 and I2 tests.
Clevidipine was more effective in maintaining the blood pressure within pre-specified ranges compared with other antihypertensive drugs (MD, -17.87 CI 95%: -29.02 to -6.72; p = 0.02). The use of Clevidipine versus placebo and rescue antihypertensive intravenous drug showed a clear reduction in rates of treatment failure (RR 0.10; IC 95%; 0.05-0.18; p <0.0001). There was no difference in the incidence of adverse events compared with placebo (RR 1.47; 95% CI 0.89 to 2.43, p = 0.14) and with other antihypertensive drugs (RR 0.78, 95% CI 0.45 to 1.35; p = 0.37). In addition, there was no difference in the incidence of atrial fibrillation (AF) between clevidipine and control groups (RR 1.09, IC del 95%: 0.65 a 1.83; p = 0.73).
Clevidipine is an ultrafast-acting drug that is highly effective for management of perioperative arterial hypertension. It is devoid of adverse effects associated with the use of other IV antihypertensives. Its favorable pharmacodynamic and pharmacokinetic properties make clevidipine the drug of choice for the management of acute perioperative hypertension. It is important to emphasize the need for further studies with a larger number of patients to confirm these findings and increase the degree of evidence.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0150625</identifier><identifier>PMID: 27018586</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Anesthesiology ; Antihypertensive Agents - pharmacology ; Antihypertensive Agents - therapeutic use ; Antihypertensives ; Atrial Fibrillation - epidemiology ; Atrial Fibrillation - pathology ; Blood ; Blood pressure ; Blood Pressure - drug effects ; Calcium Channel Blockers - therapeutic use ; Calcium channels ; Calcium channels (L-type) ; Clevidipine ; Clinical trials ; Coronary vessels ; Databases, Factual ; Drugs ; Esterases ; Excretion ; Fibrillation ; Health aspects ; Humans ; Hypertension ; Hypertension - drug therapy ; Incidence ; Intervention ; Intravenous administration ; Kidneys ; Management ; Medical research ; Medicine and Health Sciences ; Meta-analysis ; Metabolism ; Muscles ; Perioperative Care ; Pharmacodynamics ; Pharmacokinetics ; Pharmacology ; Pyridines - pharmacology ; Pyridines - therapeutic use ; Reduction ; Renal function ; Research and Analysis Methods ; Smooth muscle ; Studies ; Surgery ; Systematic review ; Thoracic surgery ; Veins & arteries</subject><ispartof>PloS one, 2016-03, Vol.11 (3), p.e0150625-e0150625</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Espinosa et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2016 Espinosa et al 2016 Espinosa et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-67aeb0e8d8631655a35c86302dd33bed212e34949f7e23b23e36ce8e002f25e23</citedby><cites>FETCH-LOGICAL-c692t-67aeb0e8d8631655a35c86302dd33bed212e34949f7e23b23e36ce8e002f25e23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4809567/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4809567/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2100,2926,23864,27922,27923,53789,53791,79370,79371</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27018586$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Fukumoto, Yoshihiro</contributor><creatorcontrib>Espinosa, Angel</creatorcontrib><creatorcontrib>Ripollés-Melchor, Javier</creatorcontrib><creatorcontrib>Casans-Francés, Rubén</creatorcontrib><creatorcontrib>Abad-Gurumeta, Alfredo</creatorcontrib><creatorcontrib>Bergese, Sergio D</creatorcontrib><creatorcontrib>Zuleta-Alarcon, Alix</creatorcontrib><creatorcontrib>López-Timoneda, Francisco</creatorcontrib><creatorcontrib>Calvo-Vecino, José María</creatorcontrib><creatorcontrib>Evidence Anesthesia Review Group</creatorcontrib><creatorcontrib>Evidence Anesthesia Review Group</creatorcontrib><title>Perioperative Use of Clevidipine: A Systematic Review and Meta-Analysis</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Clevidipine is an ultrashort-acting drug for rapid reduction of blood pressure by selectively acting on the L-type Ca2+ channels on arteriolar smooth muscle. The drug's ultrashort action in reducing the blood pressure is due to its rapid hydrolysis by blood and extravascular tissue esterases, which does not depend on hepato-renal metabolism and excretion. An analysis of the perioperative management of blood pressure should be considered to compare with other intravenous antihypertensive agents.
Analyses of the available evidence in randomized clinical trials following the PRISMA methodology as well as clinical significance according to the GRADE system were conducted. Placebo versus other antihypertensive drugs studies were included. Statistical assessments were done using the X2 and I2 tests.
Clevidipine was more effective in maintaining the blood pressure within pre-specified ranges compared with other antihypertensive drugs (MD, -17.87 CI 95%: -29.02 to -6.72; p = 0.02). The use of Clevidipine versus placebo and rescue antihypertensive intravenous drug showed a clear reduction in rates of treatment failure (RR 0.10; IC 95%; 0.05-0.18; p <0.0001). There was no difference in the incidence of adverse events compared with placebo (RR 1.47; 95% CI 0.89 to 2.43, p = 0.14) and with other antihypertensive drugs (RR 0.78, 95% CI 0.45 to 1.35; p = 0.37). In addition, there was no difference in the incidence of atrial fibrillation (AF) between clevidipine and control groups (RR 1.09, IC del 95%: 0.65 a 1.83; p = 0.73).
Clevidipine is an ultrafast-acting drug that is highly effective for management of perioperative arterial hypertension. It is devoid of adverse effects associated with the use of other IV antihypertensives. Its favorable pharmacodynamic and pharmacokinetic properties make clevidipine the drug of choice for the management of acute perioperative hypertension. It is important to emphasize the need for further studies with a larger number of patients to confirm these findings and increase the degree of evidence.</description><subject>Anesthesiology</subject><subject>Antihypertensive Agents - pharmacology</subject><subject>Antihypertensive Agents - therapeutic use</subject><subject>Antihypertensives</subject><subject>Atrial Fibrillation - epidemiology</subject><subject>Atrial Fibrillation - pathology</subject><subject>Blood</subject><subject>Blood pressure</subject><subject>Blood Pressure - drug effects</subject><subject>Calcium Channel Blockers - therapeutic use</subject><subject>Calcium channels</subject><subject>Calcium channels (L-type)</subject><subject>Clevidipine</subject><subject>Clinical trials</subject><subject>Coronary vessels</subject><subject>Databases, Factual</subject><subject>Drugs</subject><subject>Esterases</subject><subject>Excretion</subject><subject>Fibrillation</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension - drug therapy</subject><subject>Incidence</subject><subject>Intervention</subject><subject>Intravenous administration</subject><subject>Kidneys</subject><subject>Management</subject><subject>Medical research</subject><subject>Medicine and Health Sciences</subject><subject>Meta-analysis</subject><subject>Metabolism</subject><subject>Muscles</subject><subject>Perioperative Care</subject><subject>Pharmacodynamics</subject><subject>Pharmacokinetics</subject><subject>Pharmacology</subject><subject>Pyridines - pharmacology</subject><subject>Pyridines - therapeutic use</subject><subject>Reduction</subject><subject>Renal function</subject><subject>Research and Analysis Methods</subject><subject>Smooth muscle</subject><subject>Studies</subject><subject>Surgery</subject><subject>Systematic review</subject><subject>Thoracic surgery</subject><subject>Veins & arteries</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl1v0zAUhiMEYmPwDxBEQkJw0eKP2E64QKoqGJWGhjbGreXYx62rNC5xUui_x1mzqUG7QL6wdfyc9_gcv0nyEqMppgJ_WPuuqVU13foapggzxAl7lJzigpIJJ4g-PjqfJM9CWCPEaM750-SECIRzlvPT5Pw7NM5voVGt20F6EyD1Np1XsHPGbV0NH9NZer0PLWwiodOreAG_U1Wb9Bu0ajKLT9gHF54nT6yqArwY9rPk5svnH_Ovk4vL88V8djHRvCDthAsFJYLc5JxizpiiTMcjIsZQWoIhmADNiqywAggtCQXKNeSAELGExdBZ8vqgu618kMMMgsRC8DgURotILA6E8Wott43bqGYvvXLyNuCbpVRNbKUCCZaUOS60ZUJlyJgSuLDIWmp0QVGpo9anoVpXbsBoqNtGVSPR8U3tVnLpdzLLUcG4iALvBoHG_-ogtHLjgoaqUjX47vbdAokC5z365h_04e4GaqliA662PtbVvaicZYxmAlHSU9MHqLgMbJyOhrEuxkcJ70cJkWnhT7tUXQhycX31_-zlzzH79ohdgaraVfBV1zpfhzGYHUDd-BAasPdDxkj2fr-bhuz9Lge_x7RXxx90n3RncPoXVsf5kA</recordid><startdate>20160328</startdate><enddate>20160328</enddate><creator>Espinosa, Angel</creator><creator>Ripollés-Melchor, Javier</creator><creator>Casans-Francés, Rubén</creator><creator>Abad-Gurumeta, Alfredo</creator><creator>Bergese, Sergio D</creator><creator>Zuleta-Alarcon, Alix</creator><creator>López-Timoneda, Francisco</creator><creator>Calvo-Vecino, José María</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20160328</creationdate><title>Perioperative Use of Clevidipine: A Systematic Review and Meta-Analysis</title><author>Espinosa, Angel ; Ripollés-Melchor, Javier ; Casans-Francés, Rubén ; Abad-Gurumeta, Alfredo ; Bergese, Sergio D ; Zuleta-Alarcon, Alix ; López-Timoneda, Francisco ; Calvo-Vecino, José María</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-67aeb0e8d8631655a35c86302dd33bed212e34949f7e23b23e36ce8e002f25e23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Anesthesiology</topic><topic>Antihypertensive Agents - pharmacology</topic><topic>Antihypertensive Agents - therapeutic use</topic><topic>Antihypertensives</topic><topic>Atrial Fibrillation - epidemiology</topic><topic>Atrial Fibrillation - pathology</topic><topic>Blood</topic><topic>Blood pressure</topic><topic>Blood Pressure - drug effects</topic><topic>Calcium Channel Blockers - therapeutic use</topic><topic>Calcium channels</topic><topic>Calcium channels (L-type)</topic><topic>Clevidipine</topic><topic>Clinical trials</topic><topic>Coronary vessels</topic><topic>Databases, Factual</topic><topic>Drugs</topic><topic>Esterases</topic><topic>Excretion</topic><topic>Fibrillation</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Hypertension - drug therapy</topic><topic>Incidence</topic><topic>Intervention</topic><topic>Intravenous administration</topic><topic>Kidneys</topic><topic>Management</topic><topic>Medical research</topic><topic>Medicine and Health Sciences</topic><topic>Meta-analysis</topic><topic>Metabolism</topic><topic>Muscles</topic><topic>Perioperative Care</topic><topic>Pharmacodynamics</topic><topic>Pharmacokinetics</topic><topic>Pharmacology</topic><topic>Pyridines - pharmacology</topic><topic>Pyridines - therapeutic use</topic><topic>Reduction</topic><topic>Renal function</topic><topic>Research and Analysis Methods</topic><topic>Smooth muscle</topic><topic>Studies</topic><topic>Surgery</topic><topic>Systematic review</topic><topic>Thoracic surgery</topic><topic>Veins & arteries</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Espinosa, Angel</creatorcontrib><creatorcontrib>Ripollés-Melchor, Javier</creatorcontrib><creatorcontrib>Casans-Francés, Rubén</creatorcontrib><creatorcontrib>Abad-Gurumeta, Alfredo</creatorcontrib><creatorcontrib>Bergese, Sergio D</creatorcontrib><creatorcontrib>Zuleta-Alarcon, Alix</creatorcontrib><creatorcontrib>López-Timoneda, Francisco</creatorcontrib><creatorcontrib>Calvo-Vecino, José María</creatorcontrib><creatorcontrib>Evidence Anesthesia Review Group</creatorcontrib><creatorcontrib>Evidence Anesthesia Review Group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Opposing Viewpoints Resource Center</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>ProQuest Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>https://resources.nclive.org/materials</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Espinosa, Angel</au><au>Ripollés-Melchor, Javier</au><au>Casans-Francés, Rubén</au><au>Abad-Gurumeta, Alfredo</au><au>Bergese, Sergio D</au><au>Zuleta-Alarcon, Alix</au><au>López-Timoneda, Francisco</au><au>Calvo-Vecino, José María</au><au>Fukumoto, Yoshihiro</au><aucorp>Evidence Anesthesia Review Group</aucorp><aucorp>Evidence Anesthesia Review Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Perioperative Use of Clevidipine: A Systematic Review and Meta-Analysis</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2016-03-28</date><risdate>2016</risdate><volume>11</volume><issue>3</issue><spage>e0150625</spage><epage>e0150625</epage><pages>e0150625-e0150625</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Clevidipine is an ultrashort-acting drug for rapid reduction of blood pressure by selectively acting on the L-type Ca2+ channels on arteriolar smooth muscle. The drug's ultrashort action in reducing the blood pressure is due to its rapid hydrolysis by blood and extravascular tissue esterases, which does not depend on hepato-renal metabolism and excretion. An analysis of the perioperative management of blood pressure should be considered to compare with other intravenous antihypertensive agents.
Analyses of the available evidence in randomized clinical trials following the PRISMA methodology as well as clinical significance according to the GRADE system were conducted. Placebo versus other antihypertensive drugs studies were included. Statistical assessments were done using the X2 and I2 tests.
Clevidipine was more effective in maintaining the blood pressure within pre-specified ranges compared with other antihypertensive drugs (MD, -17.87 CI 95%: -29.02 to -6.72; p = 0.02). The use of Clevidipine versus placebo and rescue antihypertensive intravenous drug showed a clear reduction in rates of treatment failure (RR 0.10; IC 95%; 0.05-0.18; p <0.0001). There was no difference in the incidence of adverse events compared with placebo (RR 1.47; 95% CI 0.89 to 2.43, p = 0.14) and with other antihypertensive drugs (RR 0.78, 95% CI 0.45 to 1.35; p = 0.37). In addition, there was no difference in the incidence of atrial fibrillation (AF) between clevidipine and control groups (RR 1.09, IC del 95%: 0.65 a 1.83; p = 0.73).
Clevidipine is an ultrafast-acting drug that is highly effective for management of perioperative arterial hypertension. It is devoid of adverse effects associated with the use of other IV antihypertensives. Its favorable pharmacodynamic and pharmacokinetic properties make clevidipine the drug of choice for the management of acute perioperative hypertension. It is important to emphasize the need for further studies with a larger number of patients to confirm these findings and increase the degree of evidence.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>27018586</pmid><doi>10.1371/journal.pone.0150625</doi><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2016-03, Vol.11 (3), p.e0150625-e0150625 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1776371539 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science; PubMed Central; Free Full-Text Journals in Chemistry; EZB Electronic Journals Library |
| subjects | Anesthesiology Antihypertensive Agents - pharmacology Antihypertensive Agents - therapeutic use Antihypertensives Atrial Fibrillation - epidemiology Atrial Fibrillation - pathology Blood Blood pressure Blood Pressure - drug effects Calcium Channel Blockers - therapeutic use Calcium channels Calcium channels (L-type) Clevidipine Clinical trials Coronary vessels Databases, Factual Drugs Esterases Excretion Fibrillation Health aspects Humans Hypertension Hypertension - drug therapy Incidence Intervention Intravenous administration Kidneys Management Medical research Medicine and Health Sciences Meta-analysis Metabolism Muscles Perioperative Care Pharmacodynamics Pharmacokinetics Pharmacology Pyridines - pharmacology Pyridines - therapeutic use Reduction Renal function Research and Analysis Methods Smooth muscle Studies Surgery Systematic review Thoracic surgery Veins & arteries |
| title | Perioperative Use of Clevidipine: A Systematic Review and Meta-Analysis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-14T16%3A45%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Perioperative%20Use%20of%20Clevidipine:%20A%20Systematic%20Review%20and%20Meta-Analysis&rft.jtitle=PloS%20one&rft.au=Espinosa,%20Angel&rft.aucorp=Evidence%20Anesthesia%20Review%20Group&rft.date=2016-03-28&rft.volume=11&rft.issue=3&rft.spage=e0150625&rft.epage=e0150625&rft.pages=e0150625-e0150625&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0150625&rft_dat=%3Cgale_plos_%3EA453470329%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1776371539&rft_id=info:pmid/27018586&rft_galeid=A453470329&rft_doaj_id=oai_doaj_org_article_ef2b819cf57a40ddbe67f0ff3dc930bc&rfr_iscdi=true |