Functional Characterisation of Anticancer Activity in the Aqueous Extract of Helicteres angustifolia L. Roots

Helicteres angustifolia L. is a shrub that forms a common ingredient of several cancer treatment recipes in traditional medicine system both in China and Laos. In order to investigate molecular mechanisms of its anticancer activity, we prepared aqueous extract of Helicteres angustifolia L. Roots (AQ...

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Veröffentlicht in:	PloS one 2016-03, Vol.11 (3), p.e0152017
Hauptverfasser:	Li, Kejuan, Yu, Yue, Sun, Shuang, Liu, Ye, Garg, Sukant, Kaul, Sunil C, Lei, Zhongfang, Gao, Ran, Wadhwa, Renu, Zhang, Zhenya
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal sciences Animals Anticancer properties Antineoplastic Agents, Phytogenic - pharmacology Antitumor activity Apoptosis BAX protein Bcl-2 protein Biocompatibility Biology and Life Sciences Biomedical materials Bone cancer Breast cancer Cancer Cancer therapies Cancer treatment Cell Cycle Cell growth Cell Line, Tumor Cell Proliferation Cyclin B1 Cyclin B1 - metabolism Cyclin-Dependent Kinase Inhibitor p21 - metabolism Cytotoxicity Deoxyribonucleic acid DNA DNA Damage Dose-Response Relationship, Drug Drug dosages Environmental science Female Fibroblasts Fibroblasts - metabolism Health aspects Helicteres Helicteres angustifolia Humans Identification Laboratory animals Lung cancer Lung Neoplasms - metabolism Lung Neoplasms - pathology Lungs Malvaceae Malvaceae - chemistry Medicine and Health Sciences Metastases Metastasis Mice Mice, Inbred BALB C Mice, Nude Molecular modelling Neoplasm Metastasis Neoplasm Transplantation Osteosarcoma Osteosarcoma - drug therapy Osteosarcoma - pathology p53 Protein Plant extracts Plant Extracts - chemistry Plant Roots - chemistry Poly(ADP-ribose) Polymerases - metabolism Proteins Reactive Oxygen Species - metabolism Rodents Roots Sarcoma Signal Transduction Signaling Toxicity Tumor Suppressor Protein p53 - metabolism Xenograft Model Antitumor Assays Xenografts
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