Complement Factor H-Related Protein 3 Serum Levels Are Low Compared to Factor H and Mainly Determined by Gene Copy Number Variation in CFHR3

The major human complement regulator in blood, complement factor H (FH), has several closely related proteins, called FH-related (FHR) proteins. As all FHRs lack relevant complement regulatory activity, their physiological role is not well understood. FHR protein 3 (FHR-3) has been suggested to comp...

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Veröffentlicht in:	PloS one 2016-03, Vol.11 (3), p.e0152164-e0152164
Hauptverfasser:	Pouw, Richard B, Brouwer, Mieke C, Geissler, Judy, van Herpen, Laurens V, Zeerleder, Sacha S, Wuillemin, Walter A, Wouters, Diana, Kuijpers, Taco W
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute-Phase Reaction - blood Acute-Phase Reaction - immunology Age Antibodies, Monoclonal - immunology Biology and Life Sciences Blood Blood Proteins - analysis Blood Proteins - genetics Blood Proteins - immunology Blood serum Complement Complement factor H Complement Factor H - analysis Complement Factor H - genetics Complement system Copy number Copy number variations Cross Reactions DNA Copy Number Variations Enzyme-Linked Immunosorbent Assay Haplotypes Hematology Humans Immunology Infectious diseases Laboratories Macular degeneration Medicine and Health Sciences Mutation Pediatrics Physiological aspects Proteins Regulation Research and Analysis Methods Sepsis Sepsis - blood Sepsis - immunology Serum levels
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