Increased Plasma Levels of Heparin-Binding Protein on Admission to Intensive Care Are Associated with Respiratory and Circulatory Failure
Heparin-binding protein (HBP) is released by granulocytes and has been shown to increase vascular permeability in experimental investigations. Increased vascular permeability in the lungs can lead to fluid accumulation in alveoli and respiratory failure. A generalized increase in vascular permeabili...
Gespeichert in:
| Veröffentlicht in: | PloS one 2016-03, Vol.11 (3), p.e0152035-e0152035 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e0152035 |
|---|---|
| container_issue | 3 |
| container_start_page | e0152035 |
| container_title | PloS one |
| container_volume | 11 |
| creator | Tydén, Jonas Herwald, Heiko Sjöberg, Folke Johansson, Joakim |
| description | Heparin-binding protein (HBP) is released by granulocytes and has been shown to increase vascular permeability in experimental investigations. Increased vascular permeability in the lungs can lead to fluid accumulation in alveoli and respiratory failure. A generalized increase in vascular permeability leads to loss of circulating blood volume and circulatory failure. We hypothesized that plasma concentrations of HBP on admission to the intensive care unit (ICU) would be associated with decreased oxygenation or circulatory failure.
This is a prospective, observational study in a mixed 8-bed ICU. We investigated concentrations of HBP in plasma at admission to the ICU from 278 patients. Simplified acute physiology score (SAPS) 3 was recorded on admission. Sequential organ failure assessment (SOFA) scores were recorded daily for three days.
Median SAPS 3 was 58.8 (48-70) and 30-day mortality 64/278 (23%). There was an association between high plasma concentrations of HBP on admission with decreased oxygenation (p |
| doi_str_mv | 10.1371/journal.pone.0152035 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1775367118</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A453470650</galeid><doaj_id>oai_doaj_org_article_09d1363aa7d942d09dfdbf7d34271bbe</doaj_id><sourcerecordid>A453470650</sourcerecordid><originalsourceid>FETCH-LOGICAL-c837t-4f781e50f77450bf6d5d3f75a41227f8df5e92dcf86f81d72fa78a6838ce77d23</originalsourceid><addsrcrecordid>eNqNk9Fu0zAUhiMEYmPwBggiISG4aLHjJHZukEphrFKlTQN2a53Ex50n1y52srFH4K1x125aEUhTZMXH-c6f6D_5s-wlJWPKOP1w4YfgwI5X3uGY0KogrHqU7dOGFaM6FY_v7feyZzFeEFIxUddPs72CE8IZY_vZ75nrAkJElZ9YiEvI53iJNuZe50e4gmDc6JNxyrhFfhJ8j8bl3uUTtTQxmrTrfT5zPbpoLjGfQsB8sl4x-s5An2SvTH-en2JcmQC9D9c5OJVPTegGu6kPwdgh4PPsiQYb8cX2fpD9OPzyfXo0mh9_nU0n81EnGO9HpeaCYkU052VFWl2rSjHNKyhpUXAtlK6wKVSnRa0FVbzQwAXUgokOOVcFO8heb3RX1ke5dTFKynnFak6pSMRsQygPF3IVzBLCtfRg5M2BDwsJoTedRUkaRVnNALhqykKlUqtWc8XKgtO2xaQ132jFK1wN7Y6aHVZptWnJiBKobptSgBRYt7LkTSfbsikksEYoUVScNpDkRv-V-2zOJjcfNywHSdPU6-phvDVrnnNRJ_7j1pyhXaLq0PUB7E7b7hNnzuXCX8pSkKpgTRJ4txUI_ueAsZfpR-nQWnDohxuba9JQItbom7_Qfw9jSy0g-W2c9um93VpUTsqKlZzUFUnU-B9UuhQuTZcSok0632l4v9OQmB5_9QsYYpSzb6cPZ4_Pdtm399hzBNufR2-HPmUl7oLlBuyCjzGgvjOZErkO-K0bch1wuQ14ant1f0B3TbeJZn8A8IFMTw</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1775367118</pqid></control><display><type>article</type><title>Increased Plasma Levels of Heparin-Binding Protein on Admission to Intensive Care Are Associated with Respiratory and Circulatory Failure</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>SWEPUB Freely available online</source><source>Public Library of Science (PLoS) Journals Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Tydén, Jonas ; Herwald, Heiko ; Sjöberg, Folke ; Johansson, Joakim</creator><contributor>Lazzeri, Chiara</contributor><creatorcontrib>Tydén, Jonas ; Herwald, Heiko ; Sjöberg, Folke ; Johansson, Joakim ; Lazzeri, Chiara</creatorcontrib><description>Heparin-binding protein (HBP) is released by granulocytes and has been shown to increase vascular permeability in experimental investigations. Increased vascular permeability in the lungs can lead to fluid accumulation in alveoli and respiratory failure. A generalized increase in vascular permeability leads to loss of circulating blood volume and circulatory failure. We hypothesized that plasma concentrations of HBP on admission to the intensive care unit (ICU) would be associated with decreased oxygenation or circulatory failure.
This is a prospective, observational study in a mixed 8-bed ICU. We investigated concentrations of HBP in plasma at admission to the ICU from 278 patients. Simplified acute physiology score (SAPS) 3 was recorded on admission. Sequential organ failure assessment (SOFA) scores were recorded daily for three days.
Median SAPS 3 was 58.8 (48-70) and 30-day mortality 64/278 (23%). There was an association between high plasma concentrations of HBP on admission with decreased oxygenation (p<0.001) as well as with circulatory failure (p<0.001), after 48-72 hours in the ICU. There was an association between concentrations of HBP on admission and 30-day mortality (p = 0.002). ROC curves showed areas under the curve of 0,62 for decreased oxygenation, 0,65 for circulatory failure and 0,64 for mortality.
A high concentration of HBP in plasma on admission to the ICU is associated with respiratory and circulatory failure later during the ICU care period. It is also associated with increased 30-day mortality. Despite being an interesting biomarker for the composite ICU population it's predictive value at the individual patient level is low.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0152035</identifier><identifier>PMID: 27007333</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Aged ; Alveoli ; Anesthesiology ; Anticoagulants ; Antimicrobial Cationic Peptides - blood ; Basic Medicine ; Binding ; Bioindicators ; Biology and Life Sciences ; Biomarkers ; Biomarkers - blood ; Blood ; Blood circulation ; Blood plasma ; Blood Proteins ; Blood volume ; CAP37 protein ; Carrier Proteins - blood ; Catheters ; Cell and Molecular Biology ; Cell- och molekylärbiologi ; Clinical Medicine ; Consent ; Critical care ; Failure ; Female ; Granulocytes ; Heparin ; Hospitals ; Humans ; Illnesses ; Influence ; Intensive care ; Intensive care units ; Intensive Care Units - statistics & numerical data ; Kirurgi ; Klinisk medicin ; Leukocytes (granulocytic) ; Lungs ; Male ; Management ; Medical and Health Sciences ; Medicin och hälsovetenskap ; Medicine and Health Sciences ; Medicinska och farmaceutiska grundvetenskaper ; Middle Aged ; Mortality ; Organ Dysfunction Scores ; Oxygenation ; Patients ; Permeability ; Physiological aspects ; Plasma levels ; Predictive Value of Tests ; Prospective Studies ; Protein binding ; Proteins ; Registration ; Respiratory distress syndrome ; Respiratory failure ; Respiratory insufficiency ; Respiratory Insufficiency - blood ; Risk factors ; Sepsis ; Shock - blood ; Studies ; Surgery</subject><ispartof>PloS one, 2016-03, Vol.11 (3), p.e0152035-e0152035</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Tydén et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2016 Tydén et al 2016 Tydén et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c837t-4f781e50f77450bf6d5d3f75a41227f8df5e92dcf86f81d72fa78a6838ce77d23</citedby><cites>FETCH-LOGICAL-c837t-4f781e50f77450bf6d5d3f75a41227f8df5e92dcf86f81d72fa78a6838ce77d23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805239/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805239/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,552,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27007333$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-127786$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-120365$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttps://lup.lub.lu.se/record/a1fb948a-8e6b-479c-b492-a398d825719a$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><contributor>Lazzeri, Chiara</contributor><creatorcontrib>Tydén, Jonas</creatorcontrib><creatorcontrib>Herwald, Heiko</creatorcontrib><creatorcontrib>Sjöberg, Folke</creatorcontrib><creatorcontrib>Johansson, Joakim</creatorcontrib><title>Increased Plasma Levels of Heparin-Binding Protein on Admission to Intensive Care Are Associated with Respiratory and Circulatory Failure</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Heparin-binding protein (HBP) is released by granulocytes and has been shown to increase vascular permeability in experimental investigations. Increased vascular permeability in the lungs can lead to fluid accumulation in alveoli and respiratory failure. A generalized increase in vascular permeability leads to loss of circulating blood volume and circulatory failure. We hypothesized that plasma concentrations of HBP on admission to the intensive care unit (ICU) would be associated with decreased oxygenation or circulatory failure.
This is a prospective, observational study in a mixed 8-bed ICU. We investigated concentrations of HBP in plasma at admission to the ICU from 278 patients. Simplified acute physiology score (SAPS) 3 was recorded on admission. Sequential organ failure assessment (SOFA) scores were recorded daily for three days.
Median SAPS 3 was 58.8 (48-70) and 30-day mortality 64/278 (23%). There was an association between high plasma concentrations of HBP on admission with decreased oxygenation (p<0.001) as well as with circulatory failure (p<0.001), after 48-72 hours in the ICU. There was an association between concentrations of HBP on admission and 30-day mortality (p = 0.002). ROC curves showed areas under the curve of 0,62 for decreased oxygenation, 0,65 for circulatory failure and 0,64 for mortality.
A high concentration of HBP in plasma on admission to the ICU is associated with respiratory and circulatory failure later during the ICU care period. It is also associated with increased 30-day mortality. Despite being an interesting biomarker for the composite ICU population it's predictive value at the individual patient level is low.</description><subject>Aged</subject><subject>Alveoli</subject><subject>Anesthesiology</subject><subject>Anticoagulants</subject><subject>Antimicrobial Cationic Peptides - blood</subject><subject>Basic Medicine</subject><subject>Binding</subject><subject>Bioindicators</subject><subject>Biology and Life Sciences</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Blood</subject><subject>Blood circulation</subject><subject>Blood plasma</subject><subject>Blood Proteins</subject><subject>Blood volume</subject><subject>CAP37 protein</subject><subject>Carrier Proteins - blood</subject><subject>Catheters</subject><subject>Cell and Molecular Biology</subject><subject>Cell- och molekylärbiologi</subject><subject>Clinical Medicine</subject><subject>Consent</subject><subject>Critical care</subject><subject>Failure</subject><subject>Female</subject><subject>Granulocytes</subject><subject>Heparin</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Illnesses</subject><subject>Influence</subject><subject>Intensive care</subject><subject>Intensive care units</subject><subject>Intensive Care Units - statistics & numerical data</subject><subject>Kirurgi</subject><subject>Klinisk medicin</subject><subject>Leukocytes (granulocytic)</subject><subject>Lungs</subject><subject>Male</subject><subject>Management</subject><subject>Medical and Health Sciences</subject><subject>Medicin och hälsovetenskap</subject><subject>Medicine and Health Sciences</subject><subject>Medicinska och farmaceutiska grundvetenskaper</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Organ Dysfunction Scores</subject><subject>Oxygenation</subject><subject>Patients</subject><subject>Permeability</subject><subject>Physiological aspects</subject><subject>Plasma levels</subject><subject>Predictive Value of Tests</subject><subject>Prospective Studies</subject><subject>Protein binding</subject><subject>Proteins</subject><subject>Registration</subject><subject>Respiratory distress syndrome</subject><subject>Respiratory failure</subject><subject>Respiratory insufficiency</subject><subject>Respiratory Insufficiency - blood</subject><subject>Risk factors</subject><subject>Sepsis</subject><subject>Shock - blood</subject><subject>Studies</subject><subject>Surgery</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>D8T</sourceid><sourceid>DOA</sourceid><recordid>eNqNk9Fu0zAUhiMEYmPwBggiISG4aLHjJHZukEphrFKlTQN2a53Ex50n1y52srFH4K1x125aEUhTZMXH-c6f6D_5s-wlJWPKOP1w4YfgwI5X3uGY0KogrHqU7dOGFaM6FY_v7feyZzFeEFIxUddPs72CE8IZY_vZ75nrAkJElZ9YiEvI53iJNuZe50e4gmDc6JNxyrhFfhJ8j8bl3uUTtTQxmrTrfT5zPbpoLjGfQsB8sl4x-s5An2SvTH-en2JcmQC9D9c5OJVPTegGu6kPwdgh4PPsiQYb8cX2fpD9OPzyfXo0mh9_nU0n81EnGO9HpeaCYkU052VFWl2rSjHNKyhpUXAtlK6wKVSnRa0FVbzQwAXUgokOOVcFO8heb3RX1ke5dTFKynnFak6pSMRsQygPF3IVzBLCtfRg5M2BDwsJoTedRUkaRVnNALhqykKlUqtWc8XKgtO2xaQ132jFK1wN7Y6aHVZptWnJiBKobptSgBRYt7LkTSfbsikksEYoUVScNpDkRv-V-2zOJjcfNywHSdPU6-phvDVrnnNRJ_7j1pyhXaLq0PUB7E7b7hNnzuXCX8pSkKpgTRJ4txUI_ueAsZfpR-nQWnDohxuba9JQItbom7_Qfw9jSy0g-W2c9um93VpUTsqKlZzUFUnU-B9UuhQuTZcSok0632l4v9OQmB5_9QsYYpSzb6cPZ4_Pdtm399hzBNufR2-HPmUl7oLlBuyCjzGgvjOZErkO-K0bch1wuQ14ant1f0B3TbeJZn8A8IFMTw</recordid><startdate>20160323</startdate><enddate>20160323</enddate><creator>Tydén, Jonas</creator><creator>Herwald, Heiko</creator><creator>Sjöberg, Folke</creator><creator>Johansson, Joakim</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>ABXSW</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>DG8</scope><scope>ZZAVC</scope><scope>ADHXS</scope><scope>D93</scope><scope>AGCHP</scope><scope>D95</scope><scope>DOA</scope></search><sort><creationdate>20160323</creationdate><title>Increased Plasma Levels of Heparin-Binding Protein on Admission to Intensive Care Are Associated with Respiratory and Circulatory Failure</title><author>Tydén, Jonas ; Herwald, Heiko ; Sjöberg, Folke ; Johansson, Joakim</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c837t-4f781e50f77450bf6d5d3f75a41227f8df5e92dcf86f81d72fa78a6838ce77d23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged</topic><topic>Alveoli</topic><topic>Anesthesiology</topic><topic>Anticoagulants</topic><topic>Antimicrobial Cationic Peptides - blood</topic><topic>Basic Medicine</topic><topic>Binding</topic><topic>Bioindicators</topic><topic>Biology and Life Sciences</topic><topic>Biomarkers</topic><topic>Biomarkers - blood</topic><topic>Blood</topic><topic>Blood circulation</topic><topic>Blood plasma</topic><topic>Blood Proteins</topic><topic>Blood volume</topic><topic>CAP37 protein</topic><topic>Carrier Proteins - blood</topic><topic>Catheters</topic><topic>Cell and Molecular Biology</topic><topic>Cell- och molekylärbiologi</topic><topic>Clinical Medicine</topic><topic>Consent</topic><topic>Critical care</topic><topic>Failure</topic><topic>Female</topic><topic>Granulocytes</topic><topic>Heparin</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Illnesses</topic><topic>Influence</topic><topic>Intensive care</topic><topic>Intensive care units</topic><topic>Intensive Care Units - statistics & numerical data</topic><topic>Kirurgi</topic><topic>Klinisk medicin</topic><topic>Leukocytes (granulocytic)</topic><topic>Lungs</topic><topic>Male</topic><topic>Management</topic><topic>Medical and Health Sciences</topic><topic>Medicin och hälsovetenskap</topic><topic>Medicine and Health Sciences</topic><topic>Medicinska och farmaceutiska grundvetenskaper</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Organ Dysfunction Scores</topic><topic>Oxygenation</topic><topic>Patients</topic><topic>Permeability</topic><topic>Physiological aspects</topic><topic>Plasma levels</topic><topic>Predictive Value of Tests</topic><topic>Prospective Studies</topic><topic>Protein binding</topic><topic>Proteins</topic><topic>Registration</topic><topic>Respiratory distress syndrome</topic><topic>Respiratory failure</topic><topic>Respiratory insufficiency</topic><topic>Respiratory Insufficiency - blood</topic><topic>Risk factors</topic><topic>Sepsis</topic><topic>Shock - blood</topic><topic>Studies</topic><topic>Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tydén, Jonas</creatorcontrib><creatorcontrib>Herwald, Heiko</creatorcontrib><creatorcontrib>Sjöberg, Folke</creatorcontrib><creatorcontrib>Johansson, Joakim</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SWEPUB Linköpings universitet full text</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SWEPUB Linköpings universitet</collection><collection>SwePub Articles full text</collection><collection>SWEPUB Umeå universitet full text</collection><collection>SWEPUB Umeå universitet</collection><collection>SWEPUB Lunds universitet full text</collection><collection>SWEPUB Lunds universitet</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tydén, Jonas</au><au>Herwald, Heiko</au><au>Sjöberg, Folke</au><au>Johansson, Joakim</au><au>Lazzeri, Chiara</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased Plasma Levels of Heparin-Binding Protein on Admission to Intensive Care Are Associated with Respiratory and Circulatory Failure</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2016-03-23</date><risdate>2016</risdate><volume>11</volume><issue>3</issue><spage>e0152035</spage><epage>e0152035</epage><pages>e0152035-e0152035</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Heparin-binding protein (HBP) is released by granulocytes and has been shown to increase vascular permeability in experimental investigations. Increased vascular permeability in the lungs can lead to fluid accumulation in alveoli and respiratory failure. A generalized increase in vascular permeability leads to loss of circulating blood volume and circulatory failure. We hypothesized that plasma concentrations of HBP on admission to the intensive care unit (ICU) would be associated with decreased oxygenation or circulatory failure.
This is a prospective, observational study in a mixed 8-bed ICU. We investigated concentrations of HBP in plasma at admission to the ICU from 278 patients. Simplified acute physiology score (SAPS) 3 was recorded on admission. Sequential organ failure assessment (SOFA) scores were recorded daily for three days.
Median SAPS 3 was 58.8 (48-70) and 30-day mortality 64/278 (23%). There was an association between high plasma concentrations of HBP on admission with decreased oxygenation (p<0.001) as well as with circulatory failure (p<0.001), after 48-72 hours in the ICU. There was an association between concentrations of HBP on admission and 30-day mortality (p = 0.002). ROC curves showed areas under the curve of 0,62 for decreased oxygenation, 0,65 for circulatory failure and 0,64 for mortality.
A high concentration of HBP in plasma on admission to the ICU is associated with respiratory and circulatory failure later during the ICU care period. It is also associated with increased 30-day mortality. Despite being an interesting biomarker for the composite ICU population it's predictive value at the individual patient level is low.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>27007333</pmid><doi>10.1371/journal.pone.0152035</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2016-03, Vol.11 (3), p.e0152035-e0152035 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1775367118 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; SWEPUB Freely available online; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Aged Alveoli Anesthesiology Anticoagulants Antimicrobial Cationic Peptides - blood Basic Medicine Binding Bioindicators Biology and Life Sciences Biomarkers Biomarkers - blood Blood Blood circulation Blood plasma Blood Proteins Blood volume CAP37 protein Carrier Proteins - blood Catheters Cell and Molecular Biology Cell- och molekylärbiologi Clinical Medicine Consent Critical care Failure Female Granulocytes Heparin Hospitals Humans Illnesses Influence Intensive care Intensive care units Intensive Care Units - statistics & numerical data Kirurgi Klinisk medicin Leukocytes (granulocytic) Lungs Male Management Medical and Health Sciences Medicin och hälsovetenskap Medicine and Health Sciences Medicinska och farmaceutiska grundvetenskaper Middle Aged Mortality Organ Dysfunction Scores Oxygenation Patients Permeability Physiological aspects Plasma levels Predictive Value of Tests Prospective Studies Protein binding Proteins Registration Respiratory distress syndrome Respiratory failure Respiratory insufficiency Respiratory Insufficiency - blood Risk factors Sepsis Shock - blood Studies Surgery |
| title | Increased Plasma Levels of Heparin-Binding Protein on Admission to Intensive Care Are Associated with Respiratory and Circulatory Failure |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T01%3A42%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Increased%20Plasma%20Levels%20of%20Heparin-Binding%20Protein%20on%20Admission%20to%20Intensive%20Care%20Are%20Associated%20with%20Respiratory%20and%20Circulatory%20Failure&rft.jtitle=PloS%20one&rft.au=Tyd%C3%A9n,%20Jonas&rft.date=2016-03-23&rft.volume=11&rft.issue=3&rft.spage=e0152035&rft.epage=e0152035&rft.pages=e0152035-e0152035&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0152035&rft_dat=%3Cgale_plos_%3EA453470650%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1775367118&rft_id=info:pmid/27007333&rft_galeid=A453470650&rft_doaj_id=oai_doaj_org_article_09d1363aa7d942d09dfdbf7d34271bbe&rfr_iscdi=true |