Enhanced Diabetes Susceptibility in Community Dwelling Han Elders Carrying the Apolipoprotein E 3/3 Genotype
Despite Apolipoprotein E (ApoE) being one of the main apolipoproteins in the blood, the association between its genotype and the high cholesterol or blood glucose levels commonly seen in clinical practice is inconclusive. Such research is also lacking in the Han population. The aim of this study was...
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| creator | Ban, Chun-Xia Zhong, Li Wang, Tao Zhu, Min-Jie Wang, Jing-Hua Zhang, Zhen-Lian Wang, Zhe Su, Ning Liu, Yuan-Yuan Shi, Yan-Chen Xiao, Shi-Fu Li, Xia |
| description | Despite Apolipoprotein E (ApoE) being one of the main apolipoproteins in the blood, the association between its genotype and the high cholesterol or blood glucose levels commonly seen in clinical practice is inconclusive. Such research is also lacking in the Han population. The aim of this study was to investigate the association between APOE genotype, diabetes, and plasma glucose and lipid levels. We included 243 community-dwelling elderly residents in this study. Participant APOE genotypes were assessed and were simultaneously tested for weight, height, blood glucose, triglycerides, cholesterol, and high- and low-density lipoprotein. In addition, gender, age, years of education, cognitive function, and medical history was recorded. Subjects were divided into 3 groups based on APOE genotype: APOE ε2 group (ε2/ε2 and ε2/ε3), APOE ε3 group (ε3/ε3), and APOE ε4 group (ε2/ε4, ε3/ε4 and ε4/ε4). Comparisons between groups were conducted for the incidence of diabetes, high blood pressure, and dementia, as well as for differences in body-mass index, fasting plasma glucose, and blood lipids. The APOE ε3/ε3 genotype exhibited the highest frequency (70.4%) among the subjects. Participants in the APOE ε3 group demonstrated significantly higher levels of fasting plasma glucose than those in the APOE ε2 and APOE ε4 groups (P |
| doi_str_mv | 10.1371/journal.pone.0151336 |
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Such research is also lacking in the Han population. The aim of this study was to investigate the association between APOE genotype, diabetes, and plasma glucose and lipid levels. We included 243 community-dwelling elderly residents in this study. Participant APOE genotypes were assessed and were simultaneously tested for weight, height, blood glucose, triglycerides, cholesterol, and high- and low-density lipoprotein. In addition, gender, age, years of education, cognitive function, and medical history was recorded. Subjects were divided into 3 groups based on APOE genotype: APOE ε2 group (ε2/ε2 and ε2/ε3), APOE ε3 group (ε3/ε3), and APOE ε4 group (ε2/ε4, ε3/ε4 and ε4/ε4). Comparisons between groups were conducted for the incidence of diabetes, high blood pressure, and dementia, as well as for differences in body-mass index, fasting plasma glucose, and blood lipids. The APOE ε3/ε3 genotype exhibited the highest frequency (70.4%) among the subjects. Participants in the APOE ε3 group demonstrated significantly higher levels of fasting plasma glucose than those in the APOE ε2 and APOE ε4 groups (P<0.05). The APOE ε3 group had slightly higher abnormal fasting plasma glucose values than did the APOE ε2 group (P = 0.065). Furthermore, the APOE3 genotype was significantly correlated with both fasting plasma glucose level and glucose abnormality (P< 0.05) and trended toward statistically significant correlation with diabetes (P = 0.082). The correlation between APOE2 and low low-density lipoprotein levels also approached statistical significance (P = 0.052). Thus, elderly community dwelling residents of Han ethnicity carrying the APOE ε3/ε3 genotype might have higher plasma glucose levels and a higher occurrence of diabetes.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0151336</identifier><identifier>PMID: 26998902</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Aged ; Aged, 80 and over ; Alleles ; Analysis ; Apolipoprotein E3 - genetics ; Apolipoproteins ; Biology and Life Sciences ; Blood ; Blood Glucose - metabolism ; Blood pressure ; Cardiovascular disease ; Cholesterol ; Cognitive ability ; Communities ; Correlation ; Dementia disorders ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus - blood ; Diabetes Mellitus - genetics ; Elderly ; Ethnic Groups - genetics ; Fasting ; Female ; Genetic aspects ; Genetic Predisposition to Disease ; Genotype & phenotype ; Genotypes ; Geriatrics ; Glucose ; Health aspects ; Health risk assessment ; Heterozygote ; Humans ; Hypertension ; Independent Living ; Laboratory testing ; Lipids ; Low density lipoprotein ; Male ; Medicine and Health Sciences ; Middle Aged ; Minority & ethnic groups ; Older people ; People and places ; Population (statistical) ; Residential density ; Risk factors ; Statistical analysis ; Statistical significance ; Triglycerides</subject><ispartof>PloS one, 2016-03, Vol.11 (3), p.e0151336-e0151336</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Ban et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2016 Ban et al 2016 Ban et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-b21341bbba1f02fbf0dfba599529d58daf9a097e5dafa9d3f6cd7922cc8ea8673</citedby><cites>FETCH-LOGICAL-c692t-b21341bbba1f02fbf0dfba599529d58daf9a097e5dafa9d3f6cd7922cc8ea8673</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4801405/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4801405/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26998902$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ban, Chun-Xia</creatorcontrib><creatorcontrib>Zhong, Li</creatorcontrib><creatorcontrib>Wang, Tao</creatorcontrib><creatorcontrib>Zhu, Min-Jie</creatorcontrib><creatorcontrib>Wang, Jing-Hua</creatorcontrib><creatorcontrib>Zhang, Zhen-Lian</creatorcontrib><creatorcontrib>Wang, Zhe</creatorcontrib><creatorcontrib>Su, Ning</creatorcontrib><creatorcontrib>Liu, Yuan-Yuan</creatorcontrib><creatorcontrib>Shi, Yan-Chen</creatorcontrib><creatorcontrib>Xiao, Shi-Fu</creatorcontrib><creatorcontrib>Li, Xia</creatorcontrib><title>Enhanced Diabetes Susceptibility in Community Dwelling Han Elders Carrying the Apolipoprotein E 3/3 Genotype</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Despite Apolipoprotein E (ApoE) being one of the main apolipoproteins in the blood, the association between its genotype and the high cholesterol or blood glucose levels commonly seen in clinical practice is inconclusive. Such research is also lacking in the Han population. The aim of this study was to investigate the association between APOE genotype, diabetes, and plasma glucose and lipid levels. We included 243 community-dwelling elderly residents in this study. Participant APOE genotypes were assessed and were simultaneously tested for weight, height, blood glucose, triglycerides, cholesterol, and high- and low-density lipoprotein. In addition, gender, age, years of education, cognitive function, and medical history was recorded. Subjects were divided into 3 groups based on APOE genotype: APOE ε2 group (ε2/ε2 and ε2/ε3), APOE ε3 group (ε3/ε3), and APOE ε4 group (ε2/ε4, ε3/ε4 and ε4/ε4). Comparisons between groups were conducted for the incidence of diabetes, high blood pressure, and dementia, as well as for differences in body-mass index, fasting plasma glucose, and blood lipids. The APOE ε3/ε3 genotype exhibited the highest frequency (70.4%) among the subjects. Participants in the APOE ε3 group demonstrated significantly higher levels of fasting plasma glucose than those in the APOE ε2 and APOE ε4 groups (P<0.05). The APOE ε3 group had slightly higher abnormal fasting plasma glucose values than did the APOE ε2 group (P = 0.065). Furthermore, the APOE3 genotype was significantly correlated with both fasting plasma glucose level and glucose abnormality (P< 0.05) and trended toward statistically significant correlation with diabetes (P = 0.082). The correlation between APOE2 and low low-density lipoprotein levels also approached statistical significance (P = 0.052). Thus, elderly community dwelling residents of Han ethnicity carrying the APOE ε3/ε3 genotype might have higher plasma glucose levels and a higher occurrence of diabetes.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alleles</subject><subject>Analysis</subject><subject>Apolipoprotein E3 - genetics</subject><subject>Apolipoproteins</subject><subject>Biology and Life Sciences</subject><subject>Blood</subject><subject>Blood Glucose - metabolism</subject><subject>Blood pressure</subject><subject>Cardiovascular disease</subject><subject>Cholesterol</subject><subject>Cognitive ability</subject><subject>Communities</subject><subject>Correlation</subject><subject>Dementia disorders</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus - blood</subject><subject>Diabetes Mellitus - genetics</subject><subject>Elderly</subject><subject>Ethnic Groups - genetics</subject><subject>Fasting</subject><subject>Female</subject><subject>Genetic aspects</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype & phenotype</subject><subject>Genotypes</subject><subject>Geriatrics</subject><subject>Glucose</subject><subject>Health aspects</subject><subject>Health risk assessment</subject><subject>Heterozygote</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Independent Living</subject><subject>Laboratory testing</subject><subject>Lipids</subject><subject>Low density lipoprotein</subject><subject>Male</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Minority & ethnic groups</subject><subject>Older people</subject><subject>People and places</subject><subject>Population (statistical)</subject><subject>Residential density</subject><subject>Risk factors</subject><subject>Statistical analysis</subject><subject>Statistical significance</subject><subject>Triglycerides</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk11v0zAUhiMEYqPwDxBEQkJw0c6O8-UbpKorW6VJkxhwaznJcevJsTPbAfrvcdZsatAuUC5sHz_va_ucnCh6i9ECkwKf3Zreaq4WndGwQDjDhOTPolNMSTLPE0SeH81PolfO3SKUkTLPX0YnSU5pSVFyGqm13nFdQxOfS16BBxff9K6GzstKKun3sdTxyrRtr4fF-W9QSuptfMl1vFYNWBevuLX7IeZ3EC87o2RnOms8BOU6JmckvgBt_L6D19ELwZWDN-M4i358XX9fXc6vri82q-XVvM5p4udVgkmKq6riWKBEVAI1ouIZpVlCm6xsuKAc0QKyMOO0ISKvm4ImSV2XwMu8ILPo_cG3U8axMVGO4aJIizzLaBmIzYFoDL9lnZUtt3tmuGT3AWO3jFsvawUsg6woKKI1aSAtCaUigxISkZa0rASQ4PVlPK2vWmhq0N5yNTGd7mi5Y1vzi6UlwmmoySz6NBpYc9eD86yVoQRKcQ2mv793KByiBAf0wz_o068bqS0PD5BamHBuPZiyZZqRtEBFMdx78QQVvgZaWYe_SsgQnwg-TwSB8fDHb3nvHNvcfPt_9vrnlP14xO6AK79zRvVeGu2mYHoAa2ucsyAek4wRG5riIRtsaAo2NkWQvTsu0KPooQvIXzT2CBE</recordid><startdate>20160321</startdate><enddate>20160321</enddate><creator>Ban, 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Diabetes Susceptibility in Community Dwelling Han Elders Carrying the Apolipoprotein E 3/3 Genotype</title><author>Ban, Chun-Xia ; Zhong, Li ; Wang, Tao ; Zhu, Min-Jie ; Wang, Jing-Hua ; Zhang, Zhen-Lian ; Wang, Zhe ; Su, Ning ; Liu, Yuan-Yuan ; Shi, Yan-Chen ; Xiao, Shi-Fu ; Li, Xia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-b21341bbba1f02fbf0dfba599529d58daf9a097e5dafa9d3f6cd7922cc8ea8673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alleles</topic><topic>Analysis</topic><topic>Apolipoprotein E3 - genetics</topic><topic>Apolipoproteins</topic><topic>Biology and Life Sciences</topic><topic>Blood</topic><topic>Blood Glucose - metabolism</topic><topic>Blood pressure</topic><topic>Cardiovascular disease</topic><topic>Cholesterol</topic><topic>Cognitive 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Susceptibility in Community Dwelling Han Elders Carrying the Apolipoprotein E 3/3 Genotype</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2016-03-21</date><risdate>2016</risdate><volume>11</volume><issue>3</issue><spage>e0151336</spage><epage>e0151336</epage><pages>e0151336-e0151336</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Despite Apolipoprotein E (ApoE) being one of the main apolipoproteins in the blood, the association between its genotype and the high cholesterol or blood glucose levels commonly seen in clinical practice is inconclusive. Such research is also lacking in the Han population. The aim of this study was to investigate the association between APOE genotype, diabetes, and plasma glucose and lipid levels. We included 243 community-dwelling elderly residents in this study. Participant APOE genotypes were assessed and were simultaneously tested for weight, height, blood glucose, triglycerides, cholesterol, and high- and low-density lipoprotein. In addition, gender, age, years of education, cognitive function, and medical history was recorded. Subjects were divided into 3 groups based on APOE genotype: APOE ε2 group (ε2/ε2 and ε2/ε3), APOE ε3 group (ε3/ε3), and APOE ε4 group (ε2/ε4, ε3/ε4 and ε4/ε4). Comparisons between groups were conducted for the incidence of diabetes, high blood pressure, and dementia, as well as for differences in body-mass index, fasting plasma glucose, and blood lipids. The APOE ε3/ε3 genotype exhibited the highest frequency (70.4%) among the subjects. Participants in the APOE ε3 group demonstrated significantly higher levels of fasting plasma glucose than those in the APOE ε2 and APOE ε4 groups (P<0.05). The APOE ε3 group had slightly higher abnormal fasting plasma glucose values than did the APOE ε2 group (P = 0.065). Furthermore, the APOE3 genotype was significantly correlated with both fasting plasma glucose level and glucose abnormality (P< 0.05) and trended toward statistically significant correlation with diabetes (P = 0.082). The correlation between APOE2 and low low-density lipoprotein levels also approached statistical significance (P = 0.052). Thus, elderly community dwelling residents of Han ethnicity carrying the APOE ε3/ε3 genotype might have higher plasma glucose levels and a higher occurrence of diabetes.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26998902</pmid><doi>10.1371/journal.pone.0151336</doi><oa>free_for_read</oa></addata></record> |
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| language | eng |
| recordid | cdi_plos_journals_1774765598 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Aged Aged, 80 and over Alleles Analysis Apolipoprotein E3 - genetics Apolipoproteins Biology and Life Sciences Blood Blood Glucose - metabolism Blood pressure Cardiovascular disease Cholesterol Cognitive ability Communities Correlation Dementia disorders Diabetes Diabetes mellitus Diabetes Mellitus - blood Diabetes Mellitus - genetics Elderly Ethnic Groups - genetics Fasting Female Genetic aspects Genetic Predisposition to Disease Genotype & phenotype Genotypes Geriatrics Glucose Health aspects Health risk assessment Heterozygote Humans Hypertension Independent Living Laboratory testing Lipids Low density lipoprotein Male Medicine and Health Sciences Middle Aged Minority & ethnic groups Older people People and places Population (statistical) Residential density Risk factors Statistical analysis Statistical significance Triglycerides |
| title | Enhanced Diabetes Susceptibility in Community Dwelling Han Elders Carrying the Apolipoprotein E 3/3 Genotype |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T10%3A54%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Enhanced%20Diabetes%20Susceptibility%20in%20Community%20Dwelling%20Han%20Elders%20Carrying%20the%20Apolipoprotein%20E%203/3%20Genotype&rft.jtitle=PloS%20one&rft.au=Ban,%20Chun-Xia&rft.date=2016-03-21&rft.volume=11&rft.issue=3&rft.spage=e0151336&rft.epage=e0151336&rft.pages=e0151336-e0151336&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0151336&rft_dat=%3Cgale_plos_%3EA453470773%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1774765598&rft_id=info:pmid/26998902&rft_galeid=A453470773&rft_doaj_id=oai_doaj_org_article_5e577909c3de48399f5e8e2f4898bfe3&rfr_iscdi=true |