Oncogenic Herpesvirus Utilizes Stress-Induced Cell Cycle Checkpoints for Efficient Lytic Replication

Kaposi's sarcoma herpesvirus (KSHV) causes Kaposi's sarcoma and certain lymphoproliferative malignancies. Latent infection is established in the majority of tumor cells, whereas lytic replication is reactivated in a small fraction of cells, which is important for both virus spread and dise...

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Veröffentlicht in:	PLOS PATHOGENS 2016-02, Vol.12 (2), p.e1005424-e1005424
Hauptverfasser:	Balistreri, Giuseppe, Viiliäinen, Johanna, Turunen, Mikko, Diaz, Raquel, Lyly, Lauri, Pekkonen, Pirita, Rantala, Juha, Ojala, Krista, Sarek, Grzegorz, Teesalu, Mari, Denisova, Oxana, Peltonen, Karita, Julkunen, Ilkka, Varjosalo, Markku, Kainov, Denis, Kallioniemi, Olli, Laiho, Marikki, Taipale, Jussi, Hautaniemi, Sampsa, Ojala, Päivi M
Format:	Artikel
Sprache:	eng
Schlagworte:	Biology and Life Sciences Cell cycle Cell Cycle Checkpoints - genetics Cell death Cell Line, Tumor DNA methylation DNA Replication Gene Expression Regulation, Viral - genetics Genetic aspects Health aspects Herpesvirus 8, Human - genetics Herpesviruses Humans Kaposis sarcoma Kinases Oncogenic viruses Research and Analysis Methods RNA, Small Interfering - genetics Sarcoma, Kaposi - metabolism Sarcoma, Kaposi - virology Stress, Physiological - genetics Tumor proteins Virus Activation - physiology Virus Latency - genetics Virus replication Virus Replication - genetics
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