The Impact of Hyperthermia on Receptor-Mediated Interleukin-6 Regulation in Mouse Skeletal Muscle

In inflammatory cells, hyperthermia inhibits lipopolysaccharide (LPS)-induced interleukin-6 (IL-6) gene expression and protein secretion. Since hyperthermia alone stimulates IL-6 in skeletal muscle, we hypothesized that it would amplify responses to other receptor-mediated stimuli. IL-6 regulation w...

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Veröffentlicht in:	PloS one 2016-02, Vol.11 (2), p.e0148927-e0148927
Hauptverfasser:	Welc, Steven S, Morse, Deborah A, Mattingly, Alex J, Laitano, Orlando, King, Michelle A, Clanton, Thomas L
Format:	Artikel
Sprache:	eng
Schlagworte:	Activator protein 1 Amplification Animals Biology and Life Sciences Cell Line Comparative analysis Cytokines Engineering and Technology Epinephrine Epinephrine - metabolism Exercise Exposure Fever Fever - genetics Fever - metabolism Fibroblasts Gene expression Genetic aspects Heat Heat shock Heat shock factors Human performance Hyperthermia Inflammation Interleukin 6 Interleukin-6 - genetics Interleukin-6 - metabolism Kinases Kinesiology Ligands Lipopolysaccharides Lipopolysaccharides - metabolism Male Medicine and Health Sciences Mice Mice, Inbred C57BL Multiple organ dysfunction syndrome Muscle, Skeletal - metabolism Musculoskeletal system Myotubes Physiological aspects Physiology Promoter Regions, Genetic Proteins RNA, Messenger - genetics Rodents Signal transduction siRNA Skeletal muscle Stimulation Transcription Factor AP-1 - metabolism Transcription factors Up-Regulation
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