Synthetic prions with novel strain-specified properties

Prions are infectious proteins that possess multiple self-propagating structures. The information for strains and structural specific barriers appears to be contained exclusively in the folding of the pathological isoform, PrP(Sc). Many recent studies determined that de novo prion strains could be g...

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Veröffentlicht in:	PLoS pathogens 2015-12, Vol.11 (12), p.e1005354-e1005354
Hauptverfasser:	Moda, Fabio, Le, Thanh-Nhat T, Aulić, Suzana, Bistaffa, Edoardo, Campagnani, Ilaria, Virgilio, Tommaso, Indaco, Antonio, Palamara, Luisa, Andréoletti, Olivier, Tagliavini, Fabrizio, Legname, Giuseppe
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amyloidogenic Proteins - chemistry Animals Blotting, Western Cell Line Creutzfeldt-Jakob disease Disease Models, Animal Experiments Funding Life Sciences Mice Microscopy, Atomic Force Molecular Sequence Data Neuroblastoma Neuropathology Physiology Prion Diseases - pathology Prion Proteins Prions Prions - chemical synthesis Prions - chemistry Prions - metabolism Protein Conformation Protein Folding Proteins Recombinant Proteins - chemical synthesis Recombinant Proteins - chemistry
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