Long-Lasting Immune Protection and Other Epidemiological Findings after Chikungunya Emergence in a Cambodian Rural Community, April 2012

The East/Central/South African genotype of Chikungunya virus with the E1-A226V mutation emerged in 2011 in Cambodia and spread in 2012. An outbreak of 190 cases was documented in Trapeang Roka, a rural village. We surveyed 425 village residents within 3-4 weeks after the outbreak, and determined the...

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Veröffentlicht in:PLoS neglected tropical diseases 2016-01, Vol.10 (1), p.e0004281-e0004281
Hauptverfasser: Galatas, Beatriz, Ly, Sowath, Duong, Veasna, Baisley, Kathy, Nguon, Kunthy, Chan, Siam, Huy, Rekol, Ly, Sovann, Sorn, Sopheak, Som, Leakhann, Buchy, Philippe, Tarantola, Arnaud
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container_title PLoS neglected tropical diseases
container_volume 10
creator Galatas, Beatriz
Ly, Sowath
Duong, Veasna
Baisley, Kathy
Nguon, Kunthy
Chan, Siam
Huy, Rekol
Ly, Sovann
Sorn, Sopheak
Som, Leakhann
Buchy, Philippe
Tarantola, Arnaud
description The East/Central/South African genotype of Chikungunya virus with the E1-A226V mutation emerged in 2011 in Cambodia and spread in 2012. An outbreak of 190 cases was documented in Trapeang Roka, a rural village. We surveyed 425 village residents within 3-4 weeks after the outbreak, and determined the sensitivity and specificity of case definitions and factors associated with infection by CHIKV. Self-reported clinical presentation consisted mostly of fever, rash and arthralgia. The presence of all three clinical signs or symptoms was identified as the most sensitive (67%) and specific (84%) self-reported diagnostic clinical indicator compared to biological confirmation by MAC-ELISA or RT-PCR used as a reference. Having an indoor occupation was associated with lower odds of infection compared with people who remained at home (adjOR 0.32, 95%CI 0.12-0.82). In contrast with findings from outbreaks in other settings, persons aged above 40 years were less at risk of CHIKV infection, likely reflecting immune protection acquired when Chikungunya circulated in Cambodia before the Khmer Rouge regime in 1975. In view of the very particular history of Cambodia, our epidemiological data from Trapeang Roka are the first to support the persistence of CHIKV antibodies over a period of 40 years.
doi_str_mv 10.1371/journal.pntd.0004281
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subjects Adolescent
Adult
Aged
Aged, 80 and over
Antibodies, Viral
Antibodies, Viral - blood
Antigen-antibody reactions
Cambodia
Cambodia - epidemiology
Chikungunya Fever
Chikungunya Fever - epidemiology
Chikungunya Fever - immunology
Chikungunya Fever - pathology
Chikungunya virus
Chikungunya virus - immunology
Child
Child, Preschool
Development and progression
Disease Outbreaks
Distribution
Epidemiology
Female
Funding
Health surveillance
Human health and pathology
Humans
Immune response
Infant
Infections
Infectious diseases
Laboratories
Life Sciences
Longitudinal Studies
Male
Microbiology and Parasitology
Middle Aged
Mutation
Observations
Pandemics
Public health
Risk assessment
Risk factors
Rural areas
Rural Population
Santé publique et épidémiologie
Studies
Virology
Young Adult
title Long-Lasting Immune Protection and Other Epidemiological Findings after Chikungunya Emergence in a Cambodian Rural Community, April 2012
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