Trim33 Binds and Silences a Class of Young Endogenous Retroviruses in the Mouse Testis; a Novel Component of the Arms Race between Retrotransposons and the Host Genome

Transposable elements (TEs) have been active in the mammalian genome for millions of years and the silencing of these elements in the germline is important for the survival of the host. Mice carrying reporter transgenes can be used to model transcriptional silencing. A mutagenesis screen for modifie...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PLoS genetics 2015-12, Vol.11 (12), p.e1005693
Hauptverfasser:	Isbel, Luke, Srivastava, Rahul, Oey, Harald, Spurling, Alex, Daxinger, Lucia, Puthalakath, Hamsa, Whitelaw, Emma
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Deoxyribonucleic acid DNA DNA methylation Epigenetics Gene expression Gene Silencing Genetic aspects Genome Genomes Health aspects Histones - genetics Histones - metabolism Host-virus relationships Male Mice Mice, Inbred C57BL Mutation Observations Protein Binding Proteins Proto-Oncogene Proteins c-myb - metabolism Retroelements - genetics Retrotransposons Retroviridae - genetics Retroviruses Terminal Repeat Sequences Testis Testis - metabolism Trans-Activators - metabolism Transcription factors Transcription Factors - genetics Transcription Factors - metabolism Ubiquitin-Protein Ligases - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!