Evolutionary Analyses Suggest a Function of MxB Immunity Proteins Beyond Lentivirus Restriction

Viruses impose diverse and dynamic challenges on host defenses. Diversifying selection of codons and gene copy number variation are two hallmarks of genetic innovation in antiviral genes engaged in host-virus genetic conflicts. The myxovirus resistance (Mx) genes encode interferon-inducible GTPases...

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Veröffentlicht in:	PLoS pathogens 2015-12, Vol.11 (12), p.e1005304-e1005304
Hauptverfasser:	Mitchell, Patrick S, Young, Janet M, Emerman, Michael, Malik, Harmit S
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Datasets DNA Copy Number Variations Evolution Evolution, Molecular Genes Genetic aspects Genomes Haplorhini Host-Parasite Interactions - genetics Humans Immunity, Innate - genetics Infections Lentivirus Lentivirus Infections - genetics Mammals Molecular Sequence Data Monkeys & apes Myxovirus Resistance Proteins - genetics Natural history Phylogeny Proteins Reverse Transcriptase Polymerase Chain Reaction Viral infections Viral proteins Viruses
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