Transcriptome Analysis of Targeted Mouse Mutations Reveals the Topography of Local Changes in Gene Expression

The unintended consequences of gene targeting in mouse models have not been thoroughly studied and a more systematic analysis is needed to understand the frequency and characteristics of off-target effects. Using RNA-seq, we evaluated targeted and neighboring gene expression in tissues from 44 homoz...

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Veröffentlicht in:	PLoS genetics 2016-02, Vol.12 (2), p.e1005691
Hauptverfasser:	West, David B, Engelhard, Eric K, Adkisson, Michael, Nava, A J, Kirov, Julia V, Cipollone, Andreanna, Willis, Brandon, Rapp, Jared, de Jong, Pieter J, Lloyd, Kent C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biology and Life Sciences Chromosomes Deoxyribonucleic acid DNA Down-Regulation - genetics Gene Deletion Gene expression Gene Expression Profiling - methods Gene Expression Regulation Gene Library Gene mutation Gene Targeting Genome Genomes Homozygote Mammals Methods Mice, Inbred C57BL Mutation Mutation - genetics Observations Research and Analysis Methods RNA sequencing Topography Up-Regulation - genetics
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