A Missense LRRK2 Variant Is a Risk Factor for Excessive Inflammatory Responses in Leprosy

Depending on the epidemiological setting, a variable proportion of leprosy patients will suffer from excessive pro-inflammatory responses, termed type-1 reactions (T1R). The LRRK2 gene encodes a multi-functional protein that has been shown to modulate pro-inflammatory responses. Variants near the LR...

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Veröffentlicht in:	PLoS neglected tropical diseases 2016-02, Vol.10 (2), p.e0004412-e0004412
Hauptverfasser:	Fava, Vinicius M, Manry, Jérémy, Cobat, Aurélie, Orlova, Marianna, Van Thuc, Nguyen, Ba, Nguyen Ngoc, Thai, Vu Hong, Abel, Laurent, Alcaïs, Alexandre, Schurr, Erwin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antigens Biology and Life Sciences Disease Disease Susceptibility Female Genes Genetic aspects Genetic Association Studies Humans Inflammation Inflammation - genetics Inflammation - pathology Kinases Leprosy Leprosy - genetics Leprosy - pathology Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Male Medicine and Health Sciences Mutation, Missense Pathogens Physical Sciences Polymorphism, Single Nucleotide Protein-Serine-Threonine Kinases - genetics Research and Analysis Methods Risk factors Single nucleotide polymorphisms Studies Young Adult
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