Developing a Physiologically-Based Pharmacokinetic Model Knowledgebase in Support of Provisional Model Construction

Developing physiologically-based pharmacokinetic (PBPK) models for chemicals can be resource-intensive, as neither chemical-specific parameters nor in vivo pharmacokinetic data are easily available for model construction. Previously developed, well-parameterized, and thoroughly-vetted models can be...

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Veröffentlicht in:PLoS computational biology 2016-02, Vol.12 (2), p.e1004495-e1004495
Hauptverfasser: Lu, Jingtao, Goldsmith, Michael-Rock, Grulke, Christopher M, Chang, Daniel T, Brooks, Raina D, Leonard, Jeremy A, Phillips, Martin B, Hypes, Ethan D, Fair, Matthew J, Tornero-Velez, Rogelio, Johnson, Jeffre, Dary, Curtis C, Tan, Yu-Mei
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Sprache:eng
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