Cannabinoids Regulate Bcl-2 and Cyclin D2 Expression in Pancreatic β Cells

Recent reports have shown that cannabinoid 1 receptors (CB1Rs) are expressed in pancreatic β cells, where they induce cell death and cell cycle arrest by directly inhibiting insulin receptor activation. Here, we report that CB1Rs regulate the expression of the anti-apoptotic protein Bcl-2 and cell c...

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Veröffentlicht in:	PloS one 2016-03, Vol.11 (3), p.e0150981-e0150981
Hauptverfasser:	Kim, Jihye, Lee, Kyung Jin, Kim, Jung Seok, Rho, Jun Gi, Shin, Jung Jae, Song, Woo Keun, Lee, Eun Kyung, Egan, Josephine M, Kim, Wook
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - genetics Bcl-2 protein Biology and Life Sciences Cannabinoids Cannabinoids - pharmacology Caspase Caspase-3 Cell cycle Cell Cycle Checkpoints - drug effects Cell death Cell growth Cell Line Cell Proliferation - genetics Cell survival Clonal deletion Cyclin D2 Cyclin D2 - genetics Cyclin D2 - metabolism Cyclin-dependent kinases Diabetes mellitus Flow Cytometry G1 phase Gene Expression Regulation - drug effects Glucose Insulin Insulin resistance Insulin-Secreting Cells - drug effects Insulin-Secreting Cells - metabolism Kinases Medicine and Health Sciences Mice Mice, Inbred C57BL Pancreas Pharmacology Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-2 - metabolism Receptor mechanisms Receptor, Cannabinoid, CB1 - metabolism Receptor, Cannabinoid, CB1 - physiology Receptors Research and Analysis Methods Rodents Therapeutic applications
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