Polymorphisms of Dectin-1 and TLR2 Predispose to Invasive Fungal Disease in Patients with Acute Myeloid Leukemia

Patients with acute myeloid leukemia (AML) who undergo induction chemotherapy are at high risk for invasive fungal disease (IFD). Dectin-1, a C-type lectin family member represents one of the most important pattern recognition receptors of the innate immune system and single nucleotide polymorphisms...

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Veröffentlicht in:	PloS one 2016-03, Vol.11 (3), p.e0150632-e0150632
Hauptverfasser:	Fischer, Mike, Spies-Weisshart, Baerbel, Schrenk, Karin, Gruhn, Bernd, Wittig, Susan, Glaser, Anita, Hochhaus, Andreas, Scholl, Sebastian, Schnetzke, Ulf
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute myelocytic leukemia Acute myeloid leukemia Adult Aged Anthracycline Antineoplastic Combined Chemotherapy Protocols - administration & dosage Bacterial infections Biology and Life Sciences Blood diseases Chemotherapy Complications Complications and side effects Female Fungal diseases Fungal infections Fungi Gene expression Gene Expression Regulation, Leukemic - drug effects Genetic polymorphisms Genetic Predisposition to Disease Genotyping Health risks Human performance Humans Immune system Infection Infectious diseases Innate immunity Invasiveness Lectins, C-Type - biosynthesis Lectins, C-Type - genetics Leukemia Leukemia, Myeloid, Acute - drug therapy Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - metabolism Liver Lung Diseases, Fungal - genetics Lung Diseases, Fungal - metabolism Lung Diseases, Fungal - pathology Male Medicine and Health Sciences Middle Aged Monocytes Monocytes - metabolism Monocytes - pathology Myeloid leukemia Neoplasm Proteins - biosynthesis Neoplasm Proteins - genetics Neutrophils Patients Pattern recognition Pattern recognition receptors Pneumonia Polymorphism, Single Nucleotide Receptors Regression analysis Risk factors Single-nucleotide polymorphism TLR2 protein Toll-Like Receptor 2 - biosynthesis Toll-Like Receptor 2 - genetics Toll-like receptors Transplants & implants
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