Pancreatic B-13 Cell Trans-Differentiation to Hepatocytes Is Dependent on Epigenetic-Regulated Changes in Gene Expression

The proliferative B-13 pancreatic cell line is unique in its ability to generate functional hepatocyte-like (B-13/H) cells in response to exposure to glucocorticoid. In these studies, quantitatively comparable hepatic levels of liver-specific and liver-enriched transcription factor and hepatocyte de...

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Veröffentlicht in:	PloS one 2016-03, Vol.11 (3), p.e0150959
Hauptverfasser:	Fairhall, Emma A, Charles, Michelle A, Probert, Philip M E, Wallace, Karen, Gibb, Jennifer, Ravindan, Chandni, Soloman, Martin, Wright, Matthew C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Azacytidine Beta cells Biology and life sciences Cell differentiation Cell Line Cell Transdifferentiation - drug effects Cell Transdifferentiation - genetics Conversion Data processing Deoxyribonucleic acid Differentiation (biology) DNA DNA Methylation Epigenesis, Genetic Epigenetic inheritance Epigenetics Exposure Gene expression Gene Expression Regulation - drug effects Genetic aspects Glucocorticoids Glucocorticoids - pharmacology Hepatocytes Hepatocytes - cytology Hepatocytes - metabolism Histone deacetylase Inhibitors Kinases Liver Liver - metabolism Male Medicine and Health Sciences Nuclei Nuclei (cytology) Organ Specificity - genetics Pancreas Pancreas - cytology Pancreas - metabolism Pancreatic beta cells Phenotypes Physiological aspects Protein Transport Proteins Rats Receptors, Glucocorticoid - genetics Receptors, Glucocorticoid - metabolism Research and Analysis Methods RNA, Messenger - genetics RNA, Messenger - metabolism Rodents Stem cells Transcription, Genetic
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