Long Non-Coding RNA Malat-1 Is Dispensable during Pressure Overload-Induced Cardiac Remodeling and Failure in Mice

Long non-coding RNAs (lncRNAs) are a class of RNA molecules with diverse regulatory functions during embryonic development, normal life, and disease in higher organisms. However, research on the role of lncRNAs in cardiovascular diseases and in particular heart failure is still in its infancy. The e...

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Veröffentlicht in:	PloS one 2016-02, Vol.11 (2), p.e0150236
Hauptverfasser:	Peters, Tim, Hermans-Beijnsberger, Steffie, Beqqali, Abdelaziz, Bitsch, Nicole, Nakagawa, Shinichi, Prasanth, Kannanganattu V, de Windt, Leon J, van Oort, Ralph J, Heymans, Stephane, Schroen, Blanche
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Adenocarcinoma Alternative splicing Angiotensin Angiotensin II Angiotensin II - metabolism Angiotensin II - toxicity Animals Aorta Aorta, Thoracic Biology and Life Sciences Cancer Cardiology Cardiomegaly - etiology Cardiomegaly - genetics Cardiomyocytes Cardiomyopathy Cardiovascular diseases Constriction, Pathologic - complications Crosses, Genetic Development and progression Developmental biology Diabetes Embryogenesis Embryonic growth stage Eutrophication Fetal Proteins - biosynthesis Fetal Proteins - genetics Fibrosis Gene expression Gene Expression Regulation - genetics Genetic aspects Genotypes Heart Heart diseases Heart failure Heart Failure - etiology Heart Failure - genetics Heterozygote Hypertension Hypertrophy Hypoxia Infiltration Ligation Lung cancer Lungs MAP kinase Medical research Medicine and Health Sciences Metastases Metastasis Mice Mice, Inbred C57BL Mice, Inbred CBA Mice, Knockout MicroRNA MicroRNAs miRNA Non-coding RNA Physiological aspects Pressure Proteins - genetics Proteins - metabolism Research and Analysis Methods Ribonucleic acid RNA RNA Splicing - genetics RNA, Long Noncoding - genetics RNA, Long Noncoding - physiology Rodents Thorax Tibia Transcription Vascularization Ventricle Ventricular Remodeling - genetics
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