Combined Treatment of MCF-7 Cells with AICAR and Methotrexate, Arrests Cell Cycle and Reverses Warburg Metabolism through AMP-Activated Protein Kinase (AMPK) and FOXO1

Cancer cells are characterized by metabolic alterations, namely, depressed mitochondrial oxidation, enhanced glycolysis and pentose phosphate shunt flux to support rapid cell growth, which is called the Warburg effect. In our study we assessed the metabolic consequences of a joint treatment of MCF-7...

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Veröffentlicht in:	PloS one 2016-02, Vol.11 (2), p.e0150232-e0150232
Hauptverfasser:	Fodor, Tamás, Szántó, Magdolna, Abdul-Rahman, Omar, Nagy, Lilla, Dér, Ádám, Kiss, Borbála, Bai, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminoimidazole Carboxamide - administration & dosage Aminoimidazole Carboxamide - analogs & derivatives Aminoimidazole Carboxamide - pharmacology AMP AMP-activated protein kinase AMP-Activated Protein Kinases - metabolism Analysis Antimetabolites, Antineoplastic - pharmacology Antineoplastic Combined Chemotherapy Protocols - pharmacology Biology Biology and Life Sciences Bone Neoplasms - pathology Breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - mortality Breast Neoplasms - pathology Cancer Cancer cells Cancer therapies Cell cycle Cell Cycle - drug effects Cell division Cell Division - drug effects Cell Line, Tumor Cell proliferation Chemotherapy Combined treatment Complications and side effects Cytostatic Agents - administration & dosage Cytostatic Agents - pharmacology Data processing Dosage and administration Drug Screening Assays, Antitumor Drug Synergism Energy Metabolism - drug effects Enzyme Induction - drug effects Female Folic acid Forkhead Box Protein O1 Forkhead Transcription Factors - metabolism FOXO1 protein Gene expression Gene Expression Regulation, Neoplastic Genetic aspects Glycolysis Glycolysis - drug effects Homeostasis Humans Immunomodulators Kinases Lactates - metabolism MCF-7 Cells Medical prognosis Medicine Medicine and Health Sciences Membrane Potential, Mitochondrial - drug effects Metabolism Metabolites Methotrexate Methotrexate - administration & dosage Methotrexate - pharmacology Mitochondria Molecular Targeted Therapy Neoplasm Proteins - metabolism Osteosarcoma - pathology Oxidation Penicillin Pentose Pentose phosphate Pentose phosphate pathway Phosphates Physical Sciences Physiological aspects Protein kinases Protein turnover Ribonucleotides - administration & dosage Ribonucleotides - pharmacology RNA Interference Transcription factors Transcription Factors - antagonists & inhibitors Tumor cell lines
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