Di (2-ethylhexyl) Phthalate Exposure Impairs Growth of Antral Follicle in Mice

Di (2-ethylhexyl) phthalate (DEHP) is a widely used plastic additive. As an environmental endocrine disruptor, it has been shown to be harmful to the mammalian reproductive system. Previous studies indicated that DEHP inhibited the development of mouse ovarian follicles. However, the mechanisms by w...

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Veröffentlicht in:	PloS one 2016-02, Vol.11 (2), p.e0148350-e0148350
Hauptverfasser:	Li, Lan, Liu, Jing-Cai, Lai, Fang-Nong, Liu, Huan-Qi, Zhang, Xi-Feng, Dyce, Paul W, Shen, Wei, Chen, Hong
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Antioxidants - metabolism Apolipoprotein E Apoptosis Apoptosis - drug effects Apoptosis - genetics Biology and Life Sciences Bisphenol A Cell proliferation Cell Proliferation - genetics Cells, Cultured Developmental stages Diethylhexyl Phthalate - pharmacology DNA Damage - drug effects DNA Damage - genetics DNA methylation DNA microarrays Endocrine disruptors Endocrine Disruptors - pharmacology Enlargement Exposure Female Flow Cytometry Follicles Gene expression Gene Expression Profiling Genes Immunofluorescence Kinases Medicine and Health Sciences Mice Ovarian cancer Ovarian Follicle - drug effects Ovarian Follicle - growth & development Ovaries Oxidative stress Oxidative Stress - drug effects Oxygen Phthalates Physiological aspects Plasticizers - pharmacology Plastics Puberty Reactive oxygen species Reactive Oxygen Species - metabolism Reproductive system Reproductive systems Research and Analysis Methods RhoA protein Risk factors RNA, Messenger - biosynthesis RNA, Messenger - genetics Somatic cells
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